Molecular drug targets for scabies: a medicinal chemistry perspective
is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitor...
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| Veröffentlicht in: | Future medicinal chemistry 2020-12, Vol.12 (24), p.2225-2238 |
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| creator | Inam, Wali Walton, Shelley Khan, Sheraz Mahmood, Wajahat |
| description | is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitors of host proteolytic enzymes and other proteins of interest. These discoveries remain confined to academic laboratories and institutions, failing to attract interest from researchers in commercial drug development. Here, we summarize the latest developments in the scabies mite biology and the drug targets that were subsequently identified, and we propose several peptide and nonpeptide ligands targeting the hot spots for protein–protein interactions. We also identify gaps in the development of ligands as inhibitors or modulators of these macromolecules. |
| doi_str_mv | 10.4155/fmc-2020-0182 |
| format | Article |
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Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitors of host proteolytic enzymes and other proteins of interest. These discoveries remain confined to academic laboratories and institutions, failing to attract interest from researchers in commercial drug development. Here, we summarize the latest developments in the scabies mite biology and the drug targets that were subsequently identified, and we propose several peptide and nonpeptide ligands targeting the hot spots for protein–protein interactions. We also identify gaps in the development of ligands as inhibitors or modulators of these macromolecules.</description><identifier>ISSN: 1756-8919</identifier><identifier>EISSN: 1756-8927</identifier><identifier>DOI: 10.4155/fmc-2020-0182</identifier><identifier>PMID: 33243012</identifier><language>eng</language><publisher>England: Newlands Press Ltd</publisher><subject>Antigens ; Contraindications ; drug design ; Drug development ; Drug dosages ; Enzymes ; FDA approval ; Genomes ; Hemoglobin ; Ligands ; Macromolecules ; Mutation ; Parasites ; Parasitic diseases ; parasitism ; Protein interaction ; Proteins ; protein–protein interactions ; Proteolysis ; Proteolytic enzymes ; Scabies ; Skin ; Sulfur ; Therapeutic targets ; Womens health</subject><ispartof>Future medicinal chemistry, 2020-12, Vol.12 (24), p.2225-2238</ispartof><rights>2020 Newlands Press</rights><rights>Copyright Newlands Press Dec 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-6079612f96e0f48110194465fd528a48998ff1ecb077b6f3b535720e2ea1c4a43</citedby><cites>FETCH-LOGICAL-c371t-6079612f96e0f48110194465fd528a48998ff1ecb077b6f3b535720e2ea1c4a43</cites><orcidid>0000-0001-6568-0754</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33243012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inam, Wali</creatorcontrib><creatorcontrib>Walton, Shelley</creatorcontrib><creatorcontrib>Khan, Sheraz</creatorcontrib><creatorcontrib>Mahmood, Wajahat</creatorcontrib><title>Molecular drug targets for scabies: a medicinal chemistry perspective</title><title>Future medicinal chemistry</title><addtitle>Future Med Chem</addtitle><description>is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitors of host proteolytic enzymes and other proteins of interest. These discoveries remain confined to academic laboratories and institutions, failing to attract interest from researchers in commercial drug development. Here, we summarize the latest developments in the scabies mite biology and the drug targets that were subsequently identified, and we propose several peptide and nonpeptide ligands targeting the hot spots for protein–protein interactions. We also identify gaps in the development of ligands as inhibitors or modulators of these macromolecules.</description><subject>Antigens</subject><subject>Contraindications</subject><subject>drug design</subject><subject>Drug development</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>FDA approval</subject><subject>Genomes</subject><subject>Hemoglobin</subject><subject>Ligands</subject><subject>Macromolecules</subject><subject>Mutation</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>parasitism</subject><subject>Protein interaction</subject><subject>Proteins</subject><subject>protein–protein interactions</subject><subject>Proteolysis</subject><subject>Proteolytic enzymes</subject><subject>Scabies</subject><subject>Skin</subject><subject>Sulfur</subject><subject>Therapeutic targets</subject><subject>Womens health</subject><issn>1756-8919</issn><issn>1756-8927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kM9Kw0AQhxdRbKk9epWA5-jO_slmvUmxKlS86HnZbGdrStPE3UTo2_gsPpkpqb05l5mBjx8zHyGXQG8ESHnrK5cyymhKIWcnZAxKZmmumTo9zqBHZBrjmvbFWa4zeU5GnDPBKbAxmb_UG3TdxoZkGbpV0tqwwjYmvg5JdLYoMd4l9ue7wmXpyq3dJO4DqzK2YZc0GGKDri2_8IKcebuJOD30CXmfP7zNntLF6-Pz7H6ROq6gTTOqdAbM6wypFzkABS1EJv1SstyKXOvce0BXUKWKzPNCcqkYRYYWnLCCT8j1kNuE-rPD2Jp13YX-rGiYBMGZEpr3VDpQLtQxBvSmCWVlw84ANXtxphdn9uLMXlzPXx1Su6J_9Ej_aeoBPQC-a7uA0ZW4dWiG7aAG_wn_Bfqoe8E</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Inam, Wali</creator><creator>Walton, Shelley</creator><creator>Khan, Sheraz</creator><creator>Mahmood, Wajahat</creator><general>Newlands Press Ltd</general><general>Newlands Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-6568-0754</orcidid></search><sort><creationdate>20201201</creationdate><title>Molecular drug targets for scabies: a medicinal chemistry perspective</title><author>Inam, Wali ; Walton, Shelley ; Khan, Sheraz ; Mahmood, Wajahat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-6079612f96e0f48110194465fd528a48998ff1ecb077b6f3b535720e2ea1c4a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antigens</topic><topic>Contraindications</topic><topic>drug design</topic><topic>Drug development</topic><topic>Drug dosages</topic><topic>Enzymes</topic><topic>FDA approval</topic><topic>Genomes</topic><topic>Hemoglobin</topic><topic>Ligands</topic><topic>Macromolecules</topic><topic>Mutation</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>parasitism</topic><topic>Protein interaction</topic><topic>Proteins</topic><topic>protein–protein interactions</topic><topic>Proteolysis</topic><topic>Proteolytic enzymes</topic><topic>Scabies</topic><topic>Skin</topic><topic>Sulfur</topic><topic>Therapeutic targets</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inam, Wali</creatorcontrib><creatorcontrib>Walton, Shelley</creatorcontrib><creatorcontrib>Khan, Sheraz</creatorcontrib><creatorcontrib>Mahmood, Wajahat</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Future medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inam, Wali</au><au>Walton, Shelley</au><au>Khan, Sheraz</au><au>Mahmood, Wajahat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular drug targets for scabies: a medicinal chemistry perspective</atitle><jtitle>Future medicinal chemistry</jtitle><addtitle>Future Med Chem</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>12</volume><issue>24</issue><spage>2225</spage><epage>2238</epage><pages>2225-2238</pages><issn>1756-8919</issn><eissn>1756-8927</eissn><abstract>is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitors of host proteolytic enzymes and other proteins of interest. These discoveries remain confined to academic laboratories and institutions, failing to attract interest from researchers in commercial drug development. Here, we summarize the latest developments in the scabies mite biology and the drug targets that were subsequently identified, and we propose several peptide and nonpeptide ligands targeting the hot spots for protein–protein interactions. We also identify gaps in the development of ligands as inhibitors or modulators of these macromolecules.</abstract><cop>England</cop><pub>Newlands Press Ltd</pub><pmid>33243012</pmid><doi>10.4155/fmc-2020-0182</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-6568-0754</orcidid></addata></record> |
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| subjects | Antigens Contraindications drug design Drug development Drug dosages Enzymes FDA approval Genomes Hemoglobin Ligands Macromolecules Mutation Parasites Parasitic diseases parasitism Protein interaction Proteins protein–protein interactions Proteolysis Proteolytic enzymes Scabies Skin Sulfur Therapeutic targets Womens health |
| title | Molecular drug targets for scabies: a medicinal chemistry perspective |
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