Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma

The epigenetic abnormality is believed as a major driver for cancer initiation. Histone modification plays a vital role in tumor formation and progression. Particularly, alteration in histone acetylation has been highly associated with gene expression, cell cycle, as well as carcinogenesis. By analy...

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Veröffentlicht in:	IUBMB life 2021-05, Vol.73 (5), p.784-799
Hauptverfasser:	Zhang, Longzhou, Liu, Zengjin, Dong, Yang, Kong, Lingchang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adult Aged Animals Apoptosis Brain Neoplasms - genetics Brain Neoplasms - pathology Carcinogenesis Cation Transport Proteins - genetics Cell cycle Cell Cycle Checkpoints Cell Line, Tumor Chromatin Chromatin Immunoprecipitation Deacetylation DNA biosynthesis DNA microarrays DNA, Neoplasm - genetics epigenetic modifications Epigenetics Epithelial-Mesenchymal Transition Female Gene expression Glioblastoma Glioblastoma - genetics Glioblastoma - pathology HDAC1 Heterografts High-Throughput Nucleotide Sequencing Histone Code Histone deacetylase Histone Deacetylase 1 - genetics Histone Deacetylase 1 - physiology Humans Immunoprecipitation Male MAP kinase MAP Kinase Signaling System MAPK signaling pathway Metastases Mice Mice, Inbred NOD Mice, SCID Middle Aged Neoplasm Metastasis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Phenotype Phenotypes Protein Processing, Post-Translational Signal transduction SLC30A3 Young Adult
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