Incorporation of 5-Nitroisatin for Tailored Hydroxyapatite Nanorods and its Effect on Cervical Cancer Cells: A Nanoarchitectonics Approach
Hydroxyapatite (HAP) have been widely used as bone implants for its biocompatibility, and bioactivity. Other approaches like scaffold development, drug delivery and nanomaterials preparation are explored recently. Herein, hydroxyapatite incorporated with 5-nitroisatin (HAP-5 N) were prepared and tes...
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| Veröffentlicht in: | Journal of inorganic and organometallic polymers and materials 2021-05, Vol.31 (5), p.1946-1953 |
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| container_end_page | 1953 |
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| container_issue | 5 |
| container_start_page | 1946 |
| container_title | Journal of inorganic and organometallic polymers and materials |
| container_volume | 31 |
| creator | Karthick, V. Kumar, Dinesh Ariga, Katsuhiko Vineeth Kumar, C. M. Ganesh Kumar, V. Vasanth, K. Stalin Dhas, T. Ravi, M. Baalamurugan, J. |
| description | Hydroxyapatite (HAP) have been widely used as bone implants for its biocompatibility, and bioactivity. Other approaches like scaffold development, drug delivery and nanomaterials preparation are explored recently. Herein, hydroxyapatite incorporated with 5-nitroisatin (HAP-5 N) were prepared and tested for its anticancer potential. The prepared HAP-5 N were found to have rod like structures as seen using scanning electron microscopic analysis. The structural elucidation of 5-nitroisatin were confirmed by performing 2D heteronuclear single quantum correlation experiment. The synthesized HAP-5 N were assessed for its possible role as an anticancer agent against cervical cancer (SiHa) cells. From the study, it was found that HAP-5 N is efficient in inhibiting the growth of cervical cancer cell lines.
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| doi_str_mv | 10.1007/s10904-021-01891-9 |
| format | Article |
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Graphic Abstract</description><subject>Anticancer properties</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Cervical cancer</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Hydroxyapatite</subject><subject>Inorganic Chemistry</subject><subject>Nanomaterials</subject><subject>Nanorods</subject><subject>Organic Chemistry</subject><subject>Polymer Sciences</subject><subject>Surgical implants</subject><issn>1574-1443</issn><issn>1574-1451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1OwzAQhSMEEqVwAVaWWBv8l8RhV1WFVqrKpqwt17FpqmCHcYroFTg1pkGwY2V7_L43My_Lrim5pYSUd5GSighMGMWEyori6iQb0bwUmIqcnv7eBT_PLmLcEcIlyeko-1x4E6ALoPsmeBQcyvGq6SE0MVU8cgHQWjdtAFuj-aGG8HHQXfrqLVppHyDUEWlfo6aPaOacNT1KPlML743RLZpqbyykd9vGezQ5MhrMNvGmD74xEU26DoI228vszOk22qufc5w9P8zW0zlePj0uppMlNoKxHtuNsWnPstZMcmaY47YuSuuYKY0Woi420pRMkEJvpOCVy5101smCCE45JZaPs5vBN7V929vYq13Yg08tFcsprVjJc5lUbFAZCDGCdaqD5lXDQVGivjNXQ-YqzaKOmasqQXyAYhL7Fwt_1v9QX_fxhmc</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Karthick, V.</creator><creator>Kumar, Dinesh</creator><creator>Ariga, Katsuhiko</creator><creator>Vineeth Kumar, C. M.</creator><creator>Ganesh Kumar, V.</creator><creator>Vasanth, K.</creator><creator>Stalin Dhas, T.</creator><creator>Ravi, M.</creator><creator>Baalamurugan, J.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-1574-5158</orcidid></search><sort><creationdate>20210501</creationdate><title>Incorporation of 5-Nitroisatin for Tailored Hydroxyapatite Nanorods and its Effect on Cervical Cancer Cells: A Nanoarchitectonics Approach</title><author>Karthick, V. ; Kumar, Dinesh ; Ariga, Katsuhiko ; Vineeth Kumar, C. M. ; Ganesh Kumar, V. ; Vasanth, K. ; Stalin Dhas, T. ; Ravi, M. ; Baalamurugan, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-ebce0217da2832c2f3ed67ef2c7ca44d6b8c72406ab8439f5f8fef860431310e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anticancer properties</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Cervical cancer</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Hydroxyapatite</topic><topic>Inorganic Chemistry</topic><topic>Nanomaterials</topic><topic>Nanorods</topic><topic>Organic Chemistry</topic><topic>Polymer Sciences</topic><topic>Surgical implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karthick, V.</creatorcontrib><creatorcontrib>Kumar, Dinesh</creatorcontrib><creatorcontrib>Ariga, Katsuhiko</creatorcontrib><creatorcontrib>Vineeth Kumar, C. M.</creatorcontrib><creatorcontrib>Ganesh Kumar, V.</creatorcontrib><creatorcontrib>Vasanth, K.</creatorcontrib><creatorcontrib>Stalin Dhas, T.</creatorcontrib><creatorcontrib>Ravi, M.</creatorcontrib><creatorcontrib>Baalamurugan, J.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of inorganic and organometallic polymers and materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karthick, V.</au><au>Kumar, Dinesh</au><au>Ariga, Katsuhiko</au><au>Vineeth Kumar, C. M.</au><au>Ganesh Kumar, V.</au><au>Vasanth, K.</au><au>Stalin Dhas, T.</au><au>Ravi, M.</au><au>Baalamurugan, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incorporation of 5-Nitroisatin for Tailored Hydroxyapatite Nanorods and its Effect on Cervical Cancer Cells: A Nanoarchitectonics Approach</atitle><jtitle>Journal of inorganic and organometallic polymers and materials</jtitle><stitle>J Inorg Organomet Polym</stitle><date>2021-05-01</date><risdate>2021</risdate><volume>31</volume><issue>5</issue><spage>1946</spage><epage>1953</epage><pages>1946-1953</pages><issn>1574-1443</issn><eissn>1574-1451</eissn><abstract>Hydroxyapatite (HAP) have been widely used as bone implants for its biocompatibility, and bioactivity. Other approaches like scaffold development, drug delivery and nanomaterials preparation are explored recently. Herein, hydroxyapatite incorporated with 5-nitroisatin (HAP-5 N) were prepared and tested for its anticancer potential. The prepared HAP-5 N were found to have rod like structures as seen using scanning electron microscopic analysis. The structural elucidation of 5-nitroisatin were confirmed by performing 2D heteronuclear single quantum correlation experiment. The synthesized HAP-5 N were assessed for its possible role as an anticancer agent against cervical cancer (SiHa) cells. From the study, it was found that HAP-5 N is efficient in inhibiting the growth of cervical cancer cell lines.
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| subjects | Anticancer properties Biocompatibility Biomedical materials Cervical cancer Chemistry Chemistry and Materials Science Hydroxyapatite Inorganic Chemistry Nanomaterials Nanorods Organic Chemistry Polymer Sciences Surgical implants |
| title | Incorporation of 5-Nitroisatin for Tailored Hydroxyapatite Nanorods and its Effect on Cervical Cancer Cells: A Nanoarchitectonics Approach |
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