Variability of cycle threshold values in an external quality assessment scheme for detection of the SARS-CoV-2 virus genome by RT-PCR

The qualitative results of SARS-CoV-2 specific real-time reverse transcription (RT) PCR are used for initial diagnosis and follow-up of Covid-19 patients and asymptomatic virus carriers. However, clinical decision-making and health management policies often are based additionally on cycle threshold...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2021-04, Vol.59 (5), p.987-994
Hauptverfasser:	Buchta, Christoph, Görzer, Irene, Chiba, Peter, Camp, Jeremy V., Holzmann, Heidemarie, Puchhammer-Stöckl, Elisabeth, Mayerhofer, Maximilian, Müller, Mathias M., Aberle, Stephan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 COVID-19 - diagnosis COVID-19 Nucleic Acid Testing - methods COVID-19 Nucleic Acid Testing - statistics & numerical data cycle threshold Decision making DNA, Viral - analysis external quality assessment False Negative Reactions False Positive Reactions Genome, Viral Genomes Humans Laboratories molecular test Polymerase chain reaction Quality assessment Quality control Reverse Transcriptase Polymerase Chain Reaction - methods Reverse Transcriptase Polymerase Chain Reaction - statistics & numerical data Reverse transcription SARS-CoV-2 SARS-CoV-2 - chemistry Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Standardization Systematic errors Tomography Viruses
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