Flow topology and targeted drug delivery in cardiovascular disease
Targeted drug delivery is a promising technique to direct the drug to the specific diseased region. Nanoparticles have provided an attractive approach for this purpose. In practice, the major focus of targeted delivery has been on targeting cell receptors. However, the complex fluid mechanics in dis...
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| Veröffentlicht in: | Journal of biomechanics 2021-04, Vol.119, p.110307-110307, Article 110307 |
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| creator | Meschi, Sara S. Farghadan, Ali Arzani, Amirhossein |
| description | Targeted drug delivery is a promising technique to direct the drug to the specific diseased region. Nanoparticles have provided an attractive approach for this purpose. In practice, the major focus of targeted delivery has been on targeting cell receptors. However, the complex fluid mechanics in diseased biomedical flows questions if a sufficient number of nanoparticles can reach the desired region. In this paper, we propose that hidden topological structures in cardiovascular flows identified with Lagrangian coherent structures (LCS) control drug transport and provide valuable information for optimizing targeted drug delivery efficiency. We couple image-based computational fluid dynamics (CFD) with continuum transport models to study nanoparticle transport in coronary artery disease. We simulate nanoparticle transport as well as the recently proposed shear targeted drug delivery system that couples micro-carriers with nanoparticle drugs. The role of the LCS formed near the stenosed artery in controlling drug transport is discussed. Our results motivate the design of smart micro-needles guided by flow topology, which could achieve optimal drug delivery efficiency. |
| doi_str_mv | 10.1016/j.jbiomech.2021.110307 |
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Nanoparticles have provided an attractive approach for this purpose. In practice, the major focus of targeted delivery has been on targeting cell receptors. However, the complex fluid mechanics in diseased biomedical flows questions if a sufficient number of nanoparticles can reach the desired region. In this paper, we propose that hidden topological structures in cardiovascular flows identified with Lagrangian coherent structures (LCS) control drug transport and provide valuable information for optimizing targeted drug delivery efficiency. We couple image-based computational fluid dynamics (CFD) with continuum transport models to study nanoparticle transport in coronary artery disease. We simulate nanoparticle transport as well as the recently proposed shear targeted drug delivery system that couples micro-carriers with nanoparticle drugs. The role of the LCS formed near the stenosed artery in controlling drug transport is discussed. Our results motivate the design of smart micro-needles guided by flow topology, which could achieve optimal drug delivery efficiency.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2021.110307</identifier><identifier>PMID: 33676269</identifier><language>eng</language><publisher>OXFORD: Elsevier Ltd</publisher><subject>Atherosclerosis ; Biophysics ; Cardiovascular disease ; Cardiovascular diseases ; Computational fluid dynamics ; Computer applications ; Coronary artery ; Coronary artery disease ; Coronary artery stenosis ; Coronary vessels ; Design ; Drug delivery ; Drug delivery systems ; Drug development ; Engineering ; Engineering, Biomedical ; Fluid dynamics ; Fluid flow ; Fluid mechanics ; Heart diseases ; Hemodynamics ; Lagrangian coherent structure ; Life Sciences & Biomedicine ; Magnetic fields ; Nanoparticles ; Optimization ; Physics ; Science & Technology ; Technology ; Topology ; Transport ; Veins & arteries</subject><ispartof>Journal of biomechanics, 2021-04, Vol.119, p.110307-110307, Article 110307</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><rights>2021. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>21</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000639194100011</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c396t-9096eed7d700173f2bd4aa3ad0071b13c488f9ce1f389c16d9c61e70677776ee3</citedby><cites>FETCH-LOGICAL-c396t-9096eed7d700173f2bd4aa3ad0071b13c488f9ce1f389c16d9c61e70677776ee3</cites><orcidid>0000-0002-3706-7909</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2509596278?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,39263,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33676269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meschi, Sara S.</creatorcontrib><creatorcontrib>Farghadan, Ali</creatorcontrib><creatorcontrib>Arzani, Amirhossein</creatorcontrib><title>Flow topology and targeted drug delivery in cardiovascular disease</title><title>Journal of biomechanics</title><addtitle>J BIOMECH</addtitle><addtitle>J Biomech</addtitle><description>Targeted drug delivery is a promising technique to direct the drug to the specific diseased region. Nanoparticles have provided an attractive approach for this purpose. In practice, the major focus of targeted delivery has been on targeting cell receptors. However, the complex fluid mechanics in diseased biomedical flows questions if a sufficient number of nanoparticles can reach the desired region. In this paper, we propose that hidden topological structures in cardiovascular flows identified with Lagrangian coherent structures (LCS) control drug transport and provide valuable information for optimizing targeted drug delivery efficiency. We couple image-based computational fluid dynamics (CFD) with continuum transport models to study nanoparticle transport in coronary artery disease. We simulate nanoparticle transport as well as the recently proposed shear targeted drug delivery system that couples micro-carriers with nanoparticle drugs. The role of the LCS formed near the stenosed artery in controlling drug transport is discussed. 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Nanoparticles have provided an attractive approach for this purpose. In practice, the major focus of targeted delivery has been on targeting cell receptors. However, the complex fluid mechanics in diseased biomedical flows questions if a sufficient number of nanoparticles can reach the desired region. In this paper, we propose that hidden topological structures in cardiovascular flows identified with Lagrangian coherent structures (LCS) control drug transport and provide valuable information for optimizing targeted drug delivery efficiency. We couple image-based computational fluid dynamics (CFD) with continuum transport models to study nanoparticle transport in coronary artery disease. We simulate nanoparticle transport as well as the recently proposed shear targeted drug delivery system that couples micro-carriers with nanoparticle drugs. The role of the LCS formed near the stenosed artery in controlling drug transport is discussed. Our results motivate the design of smart micro-needles guided by flow topology, which could achieve optimal drug delivery efficiency.</abstract><cop>OXFORD</cop><pub>Elsevier Ltd</pub><pmid>33676269</pmid><doi>10.1016/j.jbiomech.2021.110307</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3706-7909</orcidid></addata></record> |
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| subjects | Atherosclerosis Biophysics Cardiovascular disease Cardiovascular diseases Computational fluid dynamics Computer applications Coronary artery Coronary artery disease Coronary artery stenosis Coronary vessels Design Drug delivery Drug delivery systems Drug development Engineering Engineering, Biomedical Fluid dynamics Fluid flow Fluid mechanics Heart diseases Hemodynamics Lagrangian coherent structure Life Sciences & Biomedicine Magnetic fields Nanoparticles Optimization Physics Science & Technology Technology Topology Transport Veins & arteries |
| title | Flow topology and targeted drug delivery in cardiovascular disease |
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