Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro

Malignant melanoma is the deadliest skin cancer, due to its propensity to metastasize. MAPKs and NF‐κB pathways are constitutively activated in melanoma and promote cell proliferation, cell invasion, metastasis formation, and resistance to therapeutic regimens. Thus, they represent potential targets...

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Veröffentlicht in:	Phytotherapy research 2021-03, Vol.35 (3), p.1432-1442
Hauptverfasser:	De Cicco, Paola, Busà, Rosalia, Ercolano, Giuseppe, Formisano, Carmen, Allegra, Mario, Taglialatela‐Scafati, Orazio, Ianaro, Angela
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antioxidants Apoptosis Carcinogenesis Carcinogens Caspase Cell growth Cell Proliferation chemoprevention cynaropicrin Disease Progression Gene expression Heme Humans Lactones Lactones - pharmacology Lactones - therapeutic use MAP kinase MAPK Melanoma Melanoma - drug therapy Metastases Mitogen-Activated Protein Kinase Kinases - metabolism NF-kappa B - metabolism Oxidative stress Oxygenase Reactive oxygen species sesquiterpene lactones Sesquiterpenes Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Signal Transduction Signaling Skin cancer Transcription activation
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