Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism

Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs. However, the effect of verapamil on the pharmacokinetics of HCPT was not clear....

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Veröffentlicht in:	Pharmaceutical biology 2020-01, Vol.58 (1), p.152-156
Hauptverfasser:	Xing, Hua, Luo, Xiao, Li, Yang, Fan, Chunni, Liu, Ning, Cui, Chunguo, Li, Wenjia
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Bioavailability CYP3A4 Drug interaction Drug-drug interaction Hepatocytes Microsomes Oral administration P-gp Pharmacokinetics Verapamil
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