In Vivo Photodynamic Therapy With a Lipophilic Zinc(II) Phthalocyanine Inhibits Colorectal Cancer and Induces a Th1/CD8 Antitumor Immune Response

Background and Objectives Photodynamic therapy (PDT) is an antitumor procedure clinically approved for the treatment of different cancer types. Despite strong efforts and promising results in this field, PDT has not yet been approved by any regulatory authority for the treatment of colorectal cancer...

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Veröffentlicht in:	Lasers in surgery and medicine 2021-03, Vol.53 (3), p.344-358
Hauptverfasser:	Chiarante, Nicolás, Duhalde Vega, Maite, Valli, Federico, Zotta, Elsa, Daghero, Hellen, Basika, Tatiana, Bollati‐Fogolin, Mariela, García Vior, María C., Marino, Julieta, Roguin, Leonor P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Apoptosis Biocompatibility Cancer Caspase CD8 antigen Cell death Colon Colorectal cancer Colorectal carcinoma Flow cytometry Immune response Immune system Immunofluorescence in vivo antitumor effect In vivo methods and tests Interferon Lasers Lipophilic Lipophilicity Lymphocytes Lymphocytes T Metastases Micelles murine colon carcinoma Photodynamic therapy phthalocyanine Poly(ADP-ribose) polymerase Regulatory agencies Toxicity Tumors
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