Radiosynthesis and quality control testing of the tau imaging positron emission tomography tracer [18F]PM‐PBB3 for clinical applications

Recently, we produced 11C‐labeled 2‐((1E,3E)‐4‐(6‐(methylamino)pyridin‐3‐yl)buta‐1,3‐dienyl)benzo[d]thiazol‐6‐ol ([11C]PBB3) as a clinically useful positron emission tomography (PET) tracer for in vivo imaging of tau pathologies in the human brain. To overcome the limitations (i.e., rapid in vivo me...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2021-03, Vol.64 (3), p.109-119
Hauptverfasser:	Kawamura, Kazunori, Hashimoto, Hiroki, Furutsuka, Kenji, Ohkubo, Takayuki, Fujishiro, Tomoya, Togashi, Takahiro, Arashi, Daisuke, Sakai, Toshiyuki, Muto, Masatoshi, Ogawa, Masanao, Kurihara, Yusuke, Nengaki, Nobuki, Takei, Makoto, Nemoto, Kazuyoshi, Higuchi, Makoto, Zhang, Ming‐Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	[18F]PM‐PBB3 Aminopyridines Benzothiazoles - chemical synthesis Benzothiazoles - chemistry Chemistry Techniques, Synthetic Emission analysis Fluorination Fluorine isotopes Fluorine Radioisotopes - chemistry fluorine‐18 Humans In vivo methods and tests Medical imaging Neuroimaging PET Positron emission Positron emission tomography Positron-Emission Tomography - methods Purity Pyridines Quality assurance Quality Control quality control testing Radioactivity Radiochemistry Radiochemistry - methods Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry radiosynthesis Synthesis tau Tau protein tau Proteins - metabolism Therapeutic applications Tomography Ultraviolet radiation
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