Pd/Cu‐Catalyzed Defluorinative Carbonylative Coupling of Aryl Iodides and gem‐Difluoroalkenes: Efficient Synthesis of α‐Fluorochalcones

An unprecedented and challenging defluorinative carbonylation was achieved. Enabled by a Pd/Cu cooperative catalyst system, the first example of defluorinative carbonylative coupling has been established. With gem‐difluoroalkenes and aryl iodides as the substrates, this methodology offers flexible a...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-04, Vol.60 (16), p.8818-8822
Hauptverfasser:	Wu, Fu‐Peng, Yuan, Yang, Liu, Jiawang, Wu, Xiao‐Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatic compounds carbonylation Carbonyls Catalysts Copper Coupling coupling reactions Intermediates Iodides Palladium Substrates α-fluorochalcones
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