Dosing Recommendations for Lamotrigine in Children: Evaluation Based on Previous and New Population Pharmacokinetic Models

Lamotrigine is a broad‐spectrum antiepileptic drug with high interindividual variability in serum concentrations in children. The aims of this study were to evaluate the predictive performance of pediatric population pharmacokinetic (PPK) models published on lamotrigine, to build a new model with ou...

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Veröffentlicht in:	Journal of clinical pharmacology 2021-05, Vol.61 (5), p.677-687
Hauptverfasser:	Tauzin, Manon, Tréluyer, Jean‐Marc, Nabbout, Rima, Billette de Villemeur, Thierry, Desguerre, Isabelle, Aboura, Radia, Gana, Ines, Zheng, Yi, Benaboud, Sihem, Bouazza, Naim, Chenevier‐Gobeaux, Camille, Freihuber, Cécile, Hirt, Déborah
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anticonvulsants - administration & dosage Anticonvulsants - adverse effects Anticonvulsants - pharmacokinetics Anticonvulsants - therapeutic use Antiepileptic agents Body Weight Child Child, Preschool Children Dosage Dose-Response Relationship, Drug dosing Drug dosages Drug Monitoring Epilepsy - drug therapy Female Humans Infant Lamotrigine Lamotrigine - administration & dosage Lamotrigine - adverse effects Lamotrigine - pharmacokinetics Lamotrigine - therapeutic use Male Metabolic Clearance Rate Models, Biological pediatrics Pharmacokinetics population pharmacokinetics Therapeutic drug monitoring
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