Stratum corneum levels of inflammatory mediators and natural moisturizing factor in patch test reactions to thiurams and fragrances and their possible role in discrimination between irritant and allergic reactions to hapten mixtures
Background Patch test (PT) reactions to thiuram mix (TM) and fragrance mix (FM) I or II without concomitant reactions to their single constituents are potentially caused by the irritant properties of the mixes. Objective Comparing inflammatory profiles of PT reactions to TM, FM I, FM II, and their c...
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| Veröffentlicht in: | Contact dermatitis 2021-05, Vol.84 (5), p.299-307 |
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| creator | Brans, Richard Jakasa, Ivone Goc, Sanja John, Swen M. Kezic, Sanja |
| description | Background
Patch test (PT) reactions to thiuram mix (TM) and fragrance mix (FM) I or II without concomitant reactions to their single constituents are potentially caused by the irritant properties of the mixes.
Objective
Comparing inflammatory profiles of PT reactions to TM, FM I, FM II, and their constituents and assessing their potential in discrimination of irritant and allergic reactions.
Patients and Methods
Levels of 14 cytokines and natural moisturizing factor (NMF) were determined in stratum corneum samples collected from PT reactions to TM, FM I or II, their constituents, and petrolatum (pet.) control sites in 36 individuals.
Results
Levels of interleukin (IL)‐16, chemokine (CXC motif) ligand (CXCL) 8, CXCL10, chemokine (CC motif) ligand (CCL) 17, and CCL22 were significantly increased in reactions (+, ++) to thiurams and fragrances compared to their petrolatum. controls, except for PT reactions to FM I/II with negative breakdown testing in which, however, decreased levels of NMF were observed. In doubtful reactions to FM I/II with negative breakdown testing, NMF was significantly lower than in petrolatum controls.
Conclusions
PT reactions to thiurams and fragrances indicate a Th2‐skewed inflammation. The inflammatory profiles suggest that weak or doubtful FM I/II reactions without accompanying reaction to a constituent were irritant. IL‐16 might be suitable to distinguish irritant from allergic reaction. |
| doi_str_mv | 10.1111/cod.13746 |
| format | Article |
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Patch test (PT) reactions to thiuram mix (TM) and fragrance mix (FM) I or II without concomitant reactions to their single constituents are potentially caused by the irritant properties of the mixes.
Objective
Comparing inflammatory profiles of PT reactions to TM, FM I, FM II, and their constituents and assessing their potential in discrimination of irritant and allergic reactions.
Patients and Methods
Levels of 14 cytokines and natural moisturizing factor (NMF) were determined in stratum corneum samples collected from PT reactions to TM, FM I or II, their constituents, and petrolatum (pet.) control sites in 36 individuals.
Results
Levels of interleukin (IL)‐16, chemokine (CXC motif) ligand (CXCL) 8, CXCL10, chemokine (CC motif) ligand (CCL) 17, and CCL22 were significantly increased in reactions (+, ++) to thiurams and fragrances compared to their petrolatum. controls, except for PT reactions to FM I/II with negative breakdown testing in which, however, decreased levels of NMF were observed. In doubtful reactions to FM I/II with negative breakdown testing, NMF was significantly lower than in petrolatum controls.
Conclusions
PT reactions to thiurams and fragrances indicate a Th2‐skewed inflammation. The inflammatory profiles suggest that weak or doubtful FM I/II reactions without accompanying reaction to a constituent were irritant. IL‐16 might be suitable to distinguish irritant from allergic reaction.</description><identifier>ISSN: 0105-1873</identifier><identifier>EISSN: 1600-0536</identifier><identifier>DOI: 10.1111/cod.13746</identifier><identifier>PMID: 33222241</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>allergic ; CCL22 protein ; Chemokines ; contact dermatitis ; CXCL10 protein ; cytokines ; Eczema ; fragrances ; Hypersensitivity ; Inflammation ; irritant ; Ligands ; Lymphocytes T ; mix ; natural moisturizing factor ; patch test ; rubber ; Stratum corneum ; thiurams</subject><ispartof>Contact dermatitis, 2021-05, Vol.84 (5), p.299-307</ispartof><rights>2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-8974d01bf4afa7b87f205b151dfd7d92ca483168d2b70c334d492cb1641f912d3</citedby><cites>FETCH-LOGICAL-c3886-8974d01bf4afa7b87f205b151dfd7d92ca483168d2b70c334d492cb1641f912d3</cites><orcidid>0000-0002-1245-024X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcod.13746$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcod.13746$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33222241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brans, Richard</creatorcontrib><creatorcontrib>Jakasa, Ivone</creatorcontrib><creatorcontrib>Goc, Sanja</creatorcontrib><creatorcontrib>John, Swen M.</creatorcontrib><creatorcontrib>Kezic, Sanja</creatorcontrib><title>Stratum corneum levels of inflammatory mediators and natural moisturizing factor in patch test reactions to thiurams and fragrances and their possible role in discrimination between irritant and allergic reactions to hapten mixtures</title><title>Contact dermatitis</title><addtitle>Contact Dermatitis</addtitle><description>Background
Patch test (PT) reactions to thiuram mix (TM) and fragrance mix (FM) I or II without concomitant reactions to their single constituents are potentially caused by the irritant properties of the mixes.
Objective
Comparing inflammatory profiles of PT reactions to TM, FM I, FM II, and their constituents and assessing their potential in discrimination of irritant and allergic reactions.
Patients and Methods
Levels of 14 cytokines and natural moisturizing factor (NMF) were determined in stratum corneum samples collected from PT reactions to TM, FM I or II, their constituents, and petrolatum (pet.) control sites in 36 individuals.
Results
Levels of interleukin (IL)‐16, chemokine (CXC motif) ligand (CXCL) 8, CXCL10, chemokine (CC motif) ligand (CCL) 17, and CCL22 were significantly increased in reactions (+, ++) to thiurams and fragrances compared to their petrolatum. controls, except for PT reactions to FM I/II with negative breakdown testing in which, however, decreased levels of NMF were observed. In doubtful reactions to FM I/II with negative breakdown testing, NMF was significantly lower than in petrolatum controls.
Conclusions
PT reactions to thiurams and fragrances indicate a Th2‐skewed inflammation. The inflammatory profiles suggest that weak or doubtful FM I/II reactions without accompanying reaction to a constituent were irritant. IL‐16 might be suitable to distinguish irritant from allergic reaction.</description><subject>allergic</subject><subject>CCL22 protein</subject><subject>Chemokines</subject><subject>contact dermatitis</subject><subject>CXCL10 protein</subject><subject>cytokines</subject><subject>Eczema</subject><subject>fragrances</subject><subject>Hypersensitivity</subject><subject>Inflammation</subject><subject>irritant</subject><subject>Ligands</subject><subject>Lymphocytes T</subject><subject>mix</subject><subject>natural moisturizing factor</subject><subject>patch test</subject><subject>rubber</subject><subject>Stratum corneum</subject><subject>thiurams</subject><issn>0105-1873</issn><issn>1600-0536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1UctOHDEQtFBQWCCH_EBkKScOA_Z4XnuMNkAiIXFIOI88fuwaeexJ2wtZvpjPoGEgUg70wW63qqrdXYR85uyUY5ypqE-5aKtmjyx4w1jBatF8IAvGWV3wrhUH5DClW8Z4U5XdR3IgRIlR8QV5_JVB5u1IVYRg8PbmzvhEo6UuWC_HUeYIOzoa7Z6zRGXQNCAFpKdjdAkz9-DCmlqpEIA0OsmsNjSblCkYrLoYEs2R5o1D2jhrWJBrkEGZ-Zk3xgGdYkpu8IZCxAOltEsK3OiwI6rQweR7YwJ1AC7LkF-o0nsDa6f-b7aRU0bk6P7iD006JvtW-mQ-vd5H5Obi_PfqR3F1fflz9e2qUKLrmqJbtpVmfLCVtLIdutaWrB54zbXVrV6WSlad4E2ny6FlSohKV1gccLHcLnmpxRH5OutOEP9scQX9bdxCwJZ9WbNlyQUuH1EnM0oBTgzG9hNOKWHXc9Y_e9qjp_2Lp4j98qq4HdCGf8g3ExFwNgPunTe795X61fX3WfIJ6gSybQ</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Brans, Richard</creator><creator>Jakasa, Ivone</creator><creator>Goc, Sanja</creator><creator>John, Swen M.</creator><creator>Kezic, Sanja</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0002-1245-024X</orcidid></search><sort><creationdate>202105</creationdate><title>Stratum corneum levels of inflammatory mediators and natural moisturizing factor in patch test reactions to thiurams and fragrances and their possible role in discrimination between irritant and allergic reactions to hapten mixtures</title><author>Brans, Richard ; Jakasa, Ivone ; Goc, Sanja ; John, Swen M. ; Kezic, Sanja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-8974d01bf4afa7b87f205b151dfd7d92ca483168d2b70c334d492cb1641f912d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>allergic</topic><topic>CCL22 protein</topic><topic>Chemokines</topic><topic>contact dermatitis</topic><topic>CXCL10 protein</topic><topic>cytokines</topic><topic>Eczema</topic><topic>fragrances</topic><topic>Hypersensitivity</topic><topic>Inflammation</topic><topic>irritant</topic><topic>Ligands</topic><topic>Lymphocytes T</topic><topic>mix</topic><topic>natural moisturizing factor</topic><topic>patch test</topic><topic>rubber</topic><topic>Stratum corneum</topic><topic>thiurams</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brans, Richard</creatorcontrib><creatorcontrib>Jakasa, Ivone</creatorcontrib><creatorcontrib>Goc, Sanja</creatorcontrib><creatorcontrib>John, Swen M.</creatorcontrib><creatorcontrib>Kezic, Sanja</creatorcontrib><collection>Wiley Online Library</collection><collection>Wiley Online Library</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Contact dermatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brans, Richard</au><au>Jakasa, Ivone</au><au>Goc, Sanja</au><au>John, Swen M.</au><au>Kezic, Sanja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stratum corneum levels of inflammatory mediators and natural moisturizing factor in patch test reactions to thiurams and fragrances and their possible role in discrimination between irritant and allergic reactions to hapten mixtures</atitle><jtitle>Contact dermatitis</jtitle><addtitle>Contact Dermatitis</addtitle><date>2021-05</date><risdate>2021</risdate><volume>84</volume><issue>5</issue><spage>299</spage><epage>307</epage><pages>299-307</pages><issn>0105-1873</issn><eissn>1600-0536</eissn><abstract>Background
Patch test (PT) reactions to thiuram mix (TM) and fragrance mix (FM) I or II without concomitant reactions to their single constituents are potentially caused by the irritant properties of the mixes.
Objective
Comparing inflammatory profiles of PT reactions to TM, FM I, FM II, and their constituents and assessing their potential in discrimination of irritant and allergic reactions.
Patients and Methods
Levels of 14 cytokines and natural moisturizing factor (NMF) were determined in stratum corneum samples collected from PT reactions to TM, FM I or II, their constituents, and petrolatum (pet.) control sites in 36 individuals.
Results
Levels of interleukin (IL)‐16, chemokine (CXC motif) ligand (CXCL) 8, CXCL10, chemokine (CC motif) ligand (CCL) 17, and CCL22 were significantly increased in reactions (+, ++) to thiurams and fragrances compared to their petrolatum. controls, except for PT reactions to FM I/II with negative breakdown testing in which, however, decreased levels of NMF were observed. In doubtful reactions to FM I/II with negative breakdown testing, NMF was significantly lower than in petrolatum controls.
Conclusions
PT reactions to thiurams and fragrances indicate a Th2‐skewed inflammation. The inflammatory profiles suggest that weak or doubtful FM I/II reactions without accompanying reaction to a constituent were irritant. IL‐16 might be suitable to distinguish irritant from allergic reaction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>33222241</pmid><doi>10.1111/cod.13746</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1245-024X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | allergic CCL22 protein Chemokines contact dermatitis CXCL10 protein cytokines Eczema fragrances Hypersensitivity Inflammation irritant Ligands Lymphocytes T mix natural moisturizing factor patch test rubber Stratum corneum thiurams |
| title | Stratum corneum levels of inflammatory mediators and natural moisturizing factor in patch test reactions to thiurams and fragrances and their possible role in discrimination between irritant and allergic reactions to hapten mixtures |
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