Lentiviral vector-mediated expression of C3 transferase attenuates retinal ischemia and reperfusion injury in rats

Our previous study showed that intravitreal delivery of self-complementary AAV2 (scAAV2)-mediated exoenzyme C3 transferase (C3) can attenuate retinal ischemia/reperfusion (I/R) injury. The current study investigated the neuroprotective effects of lentivirus (LV)-mediated C3 transgene expression on r...

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Veröffentlicht in:	Life sciences (1973) 2021-05, Vol.272, p.119269, Article 119269
Hauptverfasser:	Tan, Junkai, Liu, Guo, Lan, Chunlin, Pang, Iok-Hou, Luo, Xiaolin, Wu, Shen, Fan, Ning, Zhang, Jingxue, Wang, Ningli, Liu, Xuyang
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - metabolism ADP Ribose Transferases - pharmacology Animals Apoptosis Apoptosis - drug effects Botulinum Toxins - metabolism Botulinum Toxins - pharmacology Cell density Cell Survival - drug effects Complications Density DNA nucleotidylexotransferase Exoenzyme C3 transferase Eye (anatomy) Fluorescence Green fluorescent protein Green Fluorescent Proteins - metabolism Inflammation Injection Injuries Intraocular pressure Intraocular Pressure - drug effects Ischemia Ischemia - metabolism Ischemia - therapy Ischemia/reperfusion injury Lentivirus Lentivirus - genetics Lentivirus - metabolism Male Neuroprotection Neuroprotective Agents - pharmacology Rat Rats Rats, Sprague-Dawley Reperfusion Reperfusion Injury - metabolism Reperfusion Injury - therapy Retina Retina - metabolism Retinal cells Retinal Diseases - metabolism Retinal Diseases - therapy Retinal Ganglion Cells - metabolism RhoA protein Thickness
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