Pt() complexes based on cyclohexanediamines and the histone deacetylase inhibitor 2-(2-propynyl)octanoic acid: synthesis, characterization, cell penetration properties and antitumor activity

The Pt( iv ) complexes based on ( SP -4-2)-dichlorido(cyclohexane-1,4-diamine)platinum( ii ) (kiteplatin) and the histone deacetylase inhibitor 2-(2-propynyl)octanoic acid ( POA ) were investigated. Since POA contains a chiral carbon, all the possible Pt( iv ) isomers were prepared and characterized...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2021-04, Vol.5 (13), p.4663-4672
Hauptverfasser:	Gabano, Elisabetta, Rangone, Beatrice, Perin, Elena, Caron, Giulia, Ermondi, Giuseppe, Vallaro, Maura, Gandin, Valentina, Marzano, Cristina, Barbanente, Alessandra, Margiotta, Nicola, Ravera, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Body weight Cancer Cyclohexane Diamines Histones Inhibitors Isomers NMR Nuclear magnetic resonance Octanoic acid Penetration Platinum Weight loss
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