One-step approach of dual-responsive prodrug nanogels via Diels-Alder reaction for drug delivery

A novel strategy for the preparation of dual-responsive prodrug nanogels was proposed by Diels-Alder reaction. Firstly, poly(styrene- alt -maleic anhydride) copolymers were functionalized with furfuryl amine and hydrazine in a simple one-pot reaction. Secondly, doxorubicin (DOX) was further incorpor...

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Veröffentlicht in:	Colloid and polymer science 2021-04, Vol.299 (4), p.675-683
Hauptverfasser:	Cao, Xuan Thang, Vu-Quang, Hieu, Doan, Van-Dat, Nguyen, Van Cuong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Copolymers Crosslinking Diels-Alder reactions Disintegration Doxorubicin Food Science Hydrazines Hydrazones Maleic anhydride Nanotechnology and Microengineering Original Contribution Physical Chemistry Polymer Sciences Polystyrene resins Soft and Granular Matter Toxicity
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