Microwave assisted synthesis of Fe3O4 stabilized ZrO2 nanoparticles – Free radical scavenging, radiolabeling and biodistribution in rabbits
In vivo biodistribution of radio labeled ZrO2 nanoparticles is addressed for better imaging, therapy and diagnosis. Nanoparticles are synthesized by microwave assisted sol-gel technique using Fe3O4 as a stabilizer. Antioxidant assay, hemolytic activity in human blood and biodistribution in rabbits w...
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| Veröffentlicht in: | Life sciences (1973) 2021-04, Vol.271, p.119070, Article 119070 |
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| container_title | Life sciences (1973) |
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| creator | Sanaullah, Ifra Imran, M. Riaz, Saira Amin, Tabassum Khan, Irfan Ullah Zahoor, Rizwana Shahid, Abubaker Naseem, Shahzad |
| description | In vivo biodistribution of radio labeled ZrO2 nanoparticles is addressed for better imaging, therapy and diagnosis. Nanoparticles are synthesized by microwave assisted sol-gel technique using Fe3O4 as a stabilizer. Antioxidant assay, hemolytic activity in human blood and biodistribution in rabbits was explored to study the therapeutical as well as in vivo targeted diagnostic applications of as synthesized nanoparticles.
Fe3O4 stabilized zirconia nanoparticles are synthesized using microwave assisted sol-gel method. Microwave (MW) powers are varied in the range of 100 to 1000 W. As synthesized nanoparticles are evaluated using different characterizations such as X-ray diffractometer, scanning electron microscope, Raman spectroscopy, impedance analyzer, Vickers micro hardness indenter, FTIR, and UV–Vis spectroscopy. In vitro activity of synthesized nanoparticles is checked in freshly extracted human blood serum. To study biodistribution of Fe3O4 stabilized zirconia nanoparticles in rabbit, technetium-99 m was used for labeling purpose. The labeling efficacy and stability of labeled nanoparticles are also measured with instant thin layer chromatography (ITLC) method. Intravenous injection of 99mTc-Fe3O4 stabilized zirconia nanoparticles (0.2 ml), containing 110 MBq of radioactivity, is performed to study the biodistribution; nanoparticles are injected into the ear vein of animal (rabbit).
Zirconia (ZrO2) nanoparticles (NPs) are stabilized using Fe3O4 that were prepared by means of microwave assisted sol-gel method. Crystallite size (~20 nm) agrees well with the values required to stabilize tetragonal zirconia (t-ZrO2). Volume shrinkage results in high value of hardness (~1369). Dielectric constant values, compatible for biomedical application, are observed for tetragonally stabilized samples. Low value of hemolytic response is observed for Fe3O4 stabilized ZrO2 NPs. 99mTc radio labeled ZrO2 NPs proved to be potential candidate to study biodistribution. Biodistribution studies show stability of radiolabeled NPs in the original suspension as well as in blood serum. CT scan of rabbit is performed for several times to check the biodistribution of NPs with time and survival of rabbit. Results suggest that these NPs can also be used as targeted nanoparticles as well as variants of drug payload carrier.
Results signify that Fe3O4 stabilized ZrO2 nanoparticles synthesized by microwave assisted sol-gel method may be considered as “all-rounder” nanoplatform and are saf |
| doi_str_mv | 10.1016/j.lfs.2021.119070 |
| format | Article |
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Fe3O4 stabilized zirconia nanoparticles are synthesized using microwave assisted sol-gel method. Microwave (MW) powers are varied in the range of 100 to 1000 W. As synthesized nanoparticles are evaluated using different characterizations such as X-ray diffractometer, scanning electron microscope, Raman spectroscopy, impedance analyzer, Vickers micro hardness indenter, FTIR, and UV–Vis spectroscopy. In vitro activity of synthesized nanoparticles is checked in freshly extracted human blood serum. To study biodistribution of Fe3O4 stabilized zirconia nanoparticles in rabbit, technetium-99 m was used for labeling purpose. The labeling efficacy and stability of labeled nanoparticles are also measured with instant thin layer chromatography (ITLC) method. Intravenous injection of 99mTc-Fe3O4 stabilized zirconia nanoparticles (0.2 ml), containing 110 MBq of radioactivity, is performed to study the biodistribution; nanoparticles are injected into the ear vein of animal (rabbit).
Zirconia (ZrO2) nanoparticles (NPs) are stabilized using Fe3O4 that were prepared by means of microwave assisted sol-gel method. Crystallite size (~20 nm) agrees well with the values required to stabilize tetragonal zirconia (t-ZrO2). Volume shrinkage results in high value of hardness (~1369). Dielectric constant values, compatible for biomedical application, are observed for tetragonally stabilized samples. Low value of hemolytic response is observed for Fe3O4 stabilized ZrO2 NPs. 99mTc radio labeled ZrO2 NPs proved to be potential candidate to study biodistribution. Biodistribution studies show stability of radiolabeled NPs in the original suspension as well as in blood serum. CT scan of rabbit is performed for several times to check the biodistribution of NPs with time and survival of rabbit. Results suggest that these NPs can also be used as targeted nanoparticles as well as variants of drug payload carrier.
Results signify that Fe3O4 stabilized ZrO2 nanoparticles synthesized by microwave assisted sol-gel method may be considered as “all-rounder” nanoplatform and are safe enough to be used in diagnostic as well as therapeutic purposes.
[Display omitted]
•Microwave assisted sol-gel technique was used to synthesize Fe3O4 stabilized zirconia NPs without post heat treatment.•XRD analysis confirmed t-zirconia phase formation at and above microwave power of 500 W.•Bio-compatible value of dielectric constant with high hardness and fracture toughness was witnessed for t-zirconia phase.•High antioxidant activity with low hemolytic activity was observed for optimized Fe3O4 stabilized ZrO2 sample.•Biodistribution of NPs in rabbits was studied by intravenous injection of 99mTc-Fe3O4 stabilized zirconia nanoparticles.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2021.119070</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Antioxidants ; Biodistribution ; Biomedical materials ; Blood ; Computed tomography ; Crystallites ; Crystals ; Diagnostic software ; Dielectric constant ; Free radicals ; Hardness ; In vivo methods and tests ; Intravenous administration ; Iron oxides ; Microwave power ; Nanoparticles ; Rabbits ; Radio labeling ; Radioactivity ; Radiolabelling ; Raman spectroscopy ; Scanning electron microscopy ; Scavenging ; Sol-gel ; Sol-gel processes ; Spectroscopy ; Spectrum analysis ; Stability ; Stabilizers (agents) ; Synthesis ; Technetium ; Technetium isotopes ; Tetragonal zirconia ; Therapeutic applications ; Thin layer chromatography ; Zirconia ; Zirconium dioxide</subject><ispartof>Life sciences (1973), 2021-04, Vol.271, p.119070, Article 119070</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright Elsevier BV Apr 15, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-2240fe668d2dc1b4a54c46f928581e7962222b9ed6ef1ab250032c26edba92ee3</citedby><cites>FETCH-LOGICAL-c358t-2240fe668d2dc1b4a54c46f928581e7962222b9ed6ef1ab250032c26edba92ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320521000552$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Sanaullah, Ifra</creatorcontrib><creatorcontrib>Imran, M.</creatorcontrib><creatorcontrib>Riaz, Saira</creatorcontrib><creatorcontrib>Amin, Tabassum</creatorcontrib><creatorcontrib>Khan, Irfan Ullah</creatorcontrib><creatorcontrib>Zahoor, Rizwana</creatorcontrib><creatorcontrib>Shahid, Abubaker</creatorcontrib><creatorcontrib>Naseem, Shahzad</creatorcontrib><title>Microwave assisted synthesis of Fe3O4 stabilized ZrO2 nanoparticles – Free radical scavenging, radiolabeling and biodistribution in rabbits</title><title>Life sciences (1973)</title><description>In vivo biodistribution of radio labeled ZrO2 nanoparticles is addressed for better imaging, therapy and diagnosis. Nanoparticles are synthesized by microwave assisted sol-gel technique using Fe3O4 as a stabilizer. Antioxidant assay, hemolytic activity in human blood and biodistribution in rabbits was explored to study the therapeutical as well as in vivo targeted diagnostic applications of as synthesized nanoparticles.
Fe3O4 stabilized zirconia nanoparticles are synthesized using microwave assisted sol-gel method. Microwave (MW) powers are varied in the range of 100 to 1000 W. As synthesized nanoparticles are evaluated using different characterizations such as X-ray diffractometer, scanning electron microscope, Raman spectroscopy, impedance analyzer, Vickers micro hardness indenter, FTIR, and UV–Vis spectroscopy. In vitro activity of synthesized nanoparticles is checked in freshly extracted human blood serum. To study biodistribution of Fe3O4 stabilized zirconia nanoparticles in rabbit, technetium-99 m was used for labeling purpose. The labeling efficacy and stability of labeled nanoparticles are also measured with instant thin layer chromatography (ITLC) method. Intravenous injection of 99mTc-Fe3O4 stabilized zirconia nanoparticles (0.2 ml), containing 110 MBq of radioactivity, is performed to study the biodistribution; nanoparticles are injected into the ear vein of animal (rabbit).
Zirconia (ZrO2) nanoparticles (NPs) are stabilized using Fe3O4 that were prepared by means of microwave assisted sol-gel method. Crystallite size (~20 nm) agrees well with the values required to stabilize tetragonal zirconia (t-ZrO2). Volume shrinkage results in high value of hardness (~1369). Dielectric constant values, compatible for biomedical application, are observed for tetragonally stabilized samples. Low value of hemolytic response is observed for Fe3O4 stabilized ZrO2 NPs. 99mTc radio labeled ZrO2 NPs proved to be potential candidate to study biodistribution. Biodistribution studies show stability of radiolabeled NPs in the original suspension as well as in blood serum. CT scan of rabbit is performed for several times to check the biodistribution of NPs with time and survival of rabbit. Results suggest that these NPs can also be used as targeted nanoparticles as well as variants of drug payload carrier.
Results signify that Fe3O4 stabilized ZrO2 nanoparticles synthesized by microwave assisted sol-gel method may be considered as “all-rounder” nanoplatform and are safe enough to be used in diagnostic as well as therapeutic purposes.
[Display omitted]
•Microwave assisted sol-gel technique was used to synthesize Fe3O4 stabilized zirconia NPs without post heat treatment.•XRD analysis confirmed t-zirconia phase formation at and above microwave power of 500 W.•Bio-compatible value of dielectric constant with high hardness and fracture toughness was witnessed for t-zirconia phase.•High antioxidant activity with low hemolytic activity was observed for optimized Fe3O4 stabilized ZrO2 sample.•Biodistribution of NPs in rabbits was studied by intravenous injection of 99mTc-Fe3O4 stabilized zirconia nanoparticles.</description><subject>Antioxidants</subject><subject>Biodistribution</subject><subject>Biomedical materials</subject><subject>Blood</subject><subject>Computed tomography</subject><subject>Crystallites</subject><subject>Crystals</subject><subject>Diagnostic software</subject><subject>Dielectric constant</subject><subject>Free radicals</subject><subject>Hardness</subject><subject>In vivo methods and tests</subject><subject>Intravenous administration</subject><subject>Iron oxides</subject><subject>Microwave power</subject><subject>Nanoparticles</subject><subject>Rabbits</subject><subject>Radio labeling</subject><subject>Radioactivity</subject><subject>Radiolabelling</subject><subject>Raman spectroscopy</subject><subject>Scanning electron microscopy</subject><subject>Scavenging</subject><subject>Sol-gel</subject><subject>Sol-gel processes</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Stability</subject><subject>Stabilizers (agents)</subject><subject>Synthesis</subject><subject>Technetium</subject><subject>Technetium isotopes</subject><subject>Tetragonal zirconia</subject><subject>Therapeutic applications</subject><subject>Thin layer chromatography</subject><subject>Zirconia</subject><subject>Zirconium dioxide</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM9OHDEMxqOKSl1oH6C3SFyZJclMsjPqCSG2RaLaC71wifLHQ70akm2SBS0nXqAn3rBPQmA51xfL9vfZ1o-Qr5zNOePqdD2fxjwXTPA55wNbsA9kxvvF0DDV8gMyY0x0TSuY_EQOc14zxqRctDPy9ye6FB_MPVCTM-YCnuZdKL-hFjSOdAntqqO5GIsTPtbpTVoJGkyIG5MKugky_ff0TJcJgCbj0ZmJZlcXhlsMtydvvTgZC1MtqQmeWoy-XkpotwVjoBiqyFos-TP5OJopw5f3fER-LS-uz380V6vvl-dnV41rZV8aITo2glK9F95x2xnZuU6Ng-hlz2ExKFHDDuAVjNxYIRlrhRMKvDWDAGiPyPF-7ybFP1vIRa_jNoV6UldxLwehZF9VfK-qhHJOMOpNwjuTdpoz_Updr3Wlrl-p6z316vm290B9_x4h6ewQggOPCVzRPuJ_3C-1go0e</recordid><startdate>20210415</startdate><enddate>20210415</enddate><creator>Sanaullah, Ifra</creator><creator>Imran, M.</creator><creator>Riaz, Saira</creator><creator>Amin, Tabassum</creator><creator>Khan, Irfan Ullah</creator><creator>Zahoor, Rizwana</creator><creator>Shahid, Abubaker</creator><creator>Naseem, Shahzad</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20210415</creationdate><title>Microwave assisted synthesis of Fe3O4 stabilized ZrO2 nanoparticles – Free radical scavenging, radiolabeling and biodistribution in rabbits</title><author>Sanaullah, Ifra ; Imran, M. ; Riaz, Saira ; Amin, Tabassum ; Khan, Irfan Ullah ; Zahoor, Rizwana ; Shahid, Abubaker ; Naseem, Shahzad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-2240fe668d2dc1b4a54c46f928581e7962222b9ed6ef1ab250032c26edba92ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidants</topic><topic>Biodistribution</topic><topic>Biomedical materials</topic><topic>Blood</topic><topic>Computed tomography</topic><topic>Crystallites</topic><topic>Crystals</topic><topic>Diagnostic software</topic><topic>Dielectric constant</topic><topic>Free radicals</topic><topic>Hardness</topic><topic>In vivo methods and tests</topic><topic>Intravenous administration</topic><topic>Iron oxides</topic><topic>Microwave power</topic><topic>Nanoparticles</topic><topic>Rabbits</topic><topic>Radio labeling</topic><topic>Radioactivity</topic><topic>Radiolabelling</topic><topic>Raman spectroscopy</topic><topic>Scanning electron microscopy</topic><topic>Scavenging</topic><topic>Sol-gel</topic><topic>Sol-gel processes</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Stability</topic><topic>Stabilizers (agents)</topic><topic>Synthesis</topic><topic>Technetium</topic><topic>Technetium isotopes</topic><topic>Tetragonal zirconia</topic><topic>Therapeutic applications</topic><topic>Thin layer chromatography</topic><topic>Zirconia</topic><topic>Zirconium dioxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanaullah, Ifra</creatorcontrib><creatorcontrib>Imran, M.</creatorcontrib><creatorcontrib>Riaz, Saira</creatorcontrib><creatorcontrib>Amin, Tabassum</creatorcontrib><creatorcontrib>Khan, Irfan Ullah</creatorcontrib><creatorcontrib>Zahoor, Rizwana</creatorcontrib><creatorcontrib>Shahid, Abubaker</creatorcontrib><creatorcontrib>Naseem, Shahzad</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanaullah, Ifra</au><au>Imran, M.</au><au>Riaz, Saira</au><au>Amin, Tabassum</au><au>Khan, Irfan Ullah</au><au>Zahoor, Rizwana</au><au>Shahid, Abubaker</au><au>Naseem, Shahzad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microwave assisted synthesis of Fe3O4 stabilized ZrO2 nanoparticles – Free radical scavenging, radiolabeling and biodistribution in rabbits</atitle><jtitle>Life sciences (1973)</jtitle><date>2021-04-15</date><risdate>2021</risdate><volume>271</volume><spage>119070</spage><pages>119070-</pages><artnum>119070</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>In vivo biodistribution of radio labeled ZrO2 nanoparticles is addressed for better imaging, therapy and diagnosis. Nanoparticles are synthesized by microwave assisted sol-gel technique using Fe3O4 as a stabilizer. Antioxidant assay, hemolytic activity in human blood and biodistribution in rabbits was explored to study the therapeutical as well as in vivo targeted diagnostic applications of as synthesized nanoparticles.
Fe3O4 stabilized zirconia nanoparticles are synthesized using microwave assisted sol-gel method. Microwave (MW) powers are varied in the range of 100 to 1000 W. As synthesized nanoparticles are evaluated using different characterizations such as X-ray diffractometer, scanning electron microscope, Raman spectroscopy, impedance analyzer, Vickers micro hardness indenter, FTIR, and UV–Vis spectroscopy. In vitro activity of synthesized nanoparticles is checked in freshly extracted human blood serum. To study biodistribution of Fe3O4 stabilized zirconia nanoparticles in rabbit, technetium-99 m was used for labeling purpose. The labeling efficacy and stability of labeled nanoparticles are also measured with instant thin layer chromatography (ITLC) method. Intravenous injection of 99mTc-Fe3O4 stabilized zirconia nanoparticles (0.2 ml), containing 110 MBq of radioactivity, is performed to study the biodistribution; nanoparticles are injected into the ear vein of animal (rabbit).
Zirconia (ZrO2) nanoparticles (NPs) are stabilized using Fe3O4 that were prepared by means of microwave assisted sol-gel method. Crystallite size (~20 nm) agrees well with the values required to stabilize tetragonal zirconia (t-ZrO2). Volume shrinkage results in high value of hardness (~1369). Dielectric constant values, compatible for biomedical application, are observed for tetragonally stabilized samples. Low value of hemolytic response is observed for Fe3O4 stabilized ZrO2 NPs. 99mTc radio labeled ZrO2 NPs proved to be potential candidate to study biodistribution. Biodistribution studies show stability of radiolabeled NPs in the original suspension as well as in blood serum. CT scan of rabbit is performed for several times to check the biodistribution of NPs with time and survival of rabbit. Results suggest that these NPs can also be used as targeted nanoparticles as well as variants of drug payload carrier.
Results signify that Fe3O4 stabilized ZrO2 nanoparticles synthesized by microwave assisted sol-gel method may be considered as “all-rounder” nanoplatform and are safe enough to be used in diagnostic as well as therapeutic purposes.
[Display omitted]
•Microwave assisted sol-gel technique was used to synthesize Fe3O4 stabilized zirconia NPs without post heat treatment.•XRD analysis confirmed t-zirconia phase formation at and above microwave power of 500 W.•Bio-compatible value of dielectric constant with high hardness and fracture toughness was witnessed for t-zirconia phase.•High antioxidant activity with low hemolytic activity was observed for optimized Fe3O4 stabilized ZrO2 sample.•Biodistribution of NPs in rabbits was studied by intravenous injection of 99mTc-Fe3O4 stabilized zirconia nanoparticles.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><doi>10.1016/j.lfs.2021.119070</doi></addata></record> |
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| subjects | Antioxidants Biodistribution Biomedical materials Blood Computed tomography Crystallites Crystals Diagnostic software Dielectric constant Free radicals Hardness In vivo methods and tests Intravenous administration Iron oxides Microwave power Nanoparticles Rabbits Radio labeling Radioactivity Radiolabelling Raman spectroscopy Scanning electron microscopy Scavenging Sol-gel Sol-gel processes Spectroscopy Spectrum analysis Stability Stabilizers (agents) Synthesis Technetium Technetium isotopes Tetragonal zirconia Therapeutic applications Thin layer chromatography Zirconia Zirconium dioxide |
| title | Microwave assisted synthesis of Fe3O4 stabilized ZrO2 nanoparticles – Free radical scavenging, radiolabeling and biodistribution in rabbits |
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