Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells

Chemical modification of the thiol group on protein tyrosine phosphatase (PTP) 1B triggers an activation of epidermal growth factor receptor (EGFR) signaling that is mimicked by environmental electrophiles through S-modification of PTP1B. While activation of PTP1B/EGFR by a single exposure to an ele...

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Veröffentlicht in:	Journal of toxicological sciences 2021, Vol.46(4), pp.177-185
Hauptverfasser:	Abiko, Yumi, Kurosawa, Kohki, Yamakawa, Hiroto, Kumagai, Yoshito
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoquinone Cell death Chemical modification Cytotoxicity Electrophile Epidermal growth factor Epidermal growth factor receptor Epidermal growth factor receptors Exposure Extracellular signal-regulated kinase Growth factors Inactivation Kinases Low concentrations Naphthoquinone Phosphorylation Protein tyrosine phosphatase S-Modification Signaling Toxicity Tyrosine
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