Oligonucleotide IMT504 Improves Glucose Metabolism and Controls Immune Cell Mediators in Female Diabetic NOD Mice

Type 1 diabetes occurs as a consequence of progressive autoimmune destruction of beta cells. A potential treatment for this disease should address the immune attack on beta cells and their preservation/regeneration. The objective of this study was to elucidate whether the immunomodulatory synthetic...

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Veröffentlicht in:	Nucleic acid therapeutics 2021-04, Vol.31 (2), p.155-171
Hauptverfasser:	Bianchi, Stefania, Martínez Allo, Verónica C, Massimino, Milena, Lavignolle Heguy, María Del R, Borzone, Francisco R, Gomez Bustillo, Sofía, Chasseing, Norma A, Libertun, Carlos, Montaner, Alejandro D, Rabinovich, Gabriel A, Toscano, Marta A, Lux-Lantos, Victoria A, Bianchi, María S
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Beta cells Blood glucose CD45 antigen Diabetes Diabetes mellitus (insulin dependent) Galectin-3 Glucose Glucose metabolism Homeostasis Immune system Immunomodulation Insulitis Interleukins Leukocytes Metabolism Oligonucleotides Original Papers Pancreas Regeneration
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