Hp: an inflammatory indicator in cardiovascular disease
Over the past decade significant advancement has occurred in the biological and pathological role that Hp has in cardiovascular disease. Hp is an acute-phase protein with a role in the neutralization and clearance of free heme. Iron has tremendous potential for initiating vascular oxidation, inflamm...
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| Veröffentlicht in: | Future cardiology 2016-07, Vol.12 (4), p.471-481 |
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| creator | Graves, Karen L Vigerust, David J |
| description | Over the past decade significant advancement has occurred in the biological and pathological role that Hp has in cardiovascular disease. Hp is an acute-phase protein with a role in the neutralization and clearance of free heme. Iron has tremendous potential for initiating vascular oxidation, inflammation and exacerbating coronary atherosclerosis. Hp genotype has been linked as a prognostic biomarker of acute myocardial infarction, heart failure, restenosis and cardiac transplant rejection. The increased understanding of Hp as a biomarker has provided new insights into the mechanisms of inflammation after cardiac injury and support the concept that Hp is not only an important antioxidant in vascular inflammation and atherosclerosis, but also an enhancer of inflammation in cardiac transplant. |
| doi_str_mv | 10.2217/fca-2016-0008 |
| format | Article |
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Hp is an acute-phase protein with a role in the neutralization and clearance of free heme. Iron has tremendous potential for initiating vascular oxidation, inflammation and exacerbating coronary atherosclerosis. Hp genotype has been linked as a prognostic biomarker of acute myocardial infarction, heart failure, restenosis and cardiac transplant rejection. The increased understanding of Hp as a biomarker has provided new insights into the mechanisms of inflammation after cardiac injury and support the concept that Hp is not only an important antioxidant in vascular inflammation and atherosclerosis, but also an enhancer of inflammation in cardiac transplant.</description><identifier>ISSN: 1479-6678</identifier><identifier>EISSN: 1744-8298</identifier><identifier>DOI: 10.2217/fca-2016-0008</identifier><identifier>PMID: 27203711</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Antioxidants ; Atherosclerosis - blood ; Binding sites ; Biomarkers - blood ; cardiac transplant ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cytokines ; Diabetes ; Enzymes ; Genotype ; Genotype & phenotype ; Graft Rejection - blood ; haptoglobin ; Haptoglobins - genetics ; Haptoglobins - physiology ; Heart attacks ; heart failure ; Heart Failure - blood ; Heart Transplantation ; Hemoglobin ; Humans ; Iron ; Iron - physiology ; Lipid peroxidation ; myocardial infarction ; Myocardial Infarction - blood ; Oxidation ; percutaneous intervention ; Permeability ; Polymorphism ; Prognosis ; Proteins ; restenosis ; vascular inflammation ; vitamin E</subject><ispartof>Future cardiology, 2016-07, Vol.12 (4), p.471-481</ispartof><rights>Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Jul 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-274a1dde00cdd8df01ad2894a95b7b5073c99dbb3ec01f59d08685409eb67e5e3</citedby><cites>FETCH-LOGICAL-c371t-274a1dde00cdd8df01ad2894a95b7b5073c99dbb3ec01f59d08685409eb67e5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27203711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graves, Karen L</creatorcontrib><creatorcontrib>Vigerust, David J</creatorcontrib><title>Hp: an inflammatory indicator in cardiovascular disease</title><title>Future cardiology</title><addtitle>Future Cardiol</addtitle><description>Over the past decade significant advancement has occurred in the biological and pathological role that Hp has in cardiovascular disease. Hp is an acute-phase protein with a role in the neutralization and clearance of free heme. Iron has tremendous potential for initiating vascular oxidation, inflammation and exacerbating coronary atherosclerosis. Hp genotype has been linked as a prognostic biomarker of acute myocardial infarction, heart failure, restenosis and cardiac transplant rejection. The increased understanding of Hp as a biomarker has provided new insights into the mechanisms of inflammation after cardiac injury and support the concept that Hp is not only an important antioxidant in vascular inflammation and atherosclerosis, but also an enhancer of inflammation in cardiac transplant.</description><subject>Antioxidants</subject><subject>Atherosclerosis - blood</subject><subject>Binding sites</subject><subject>Biomarkers - blood</subject><subject>cardiac transplant</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Enzymes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Graft Rejection - blood</subject><subject>haptoglobin</subject><subject>Haptoglobins - genetics</subject><subject>Haptoglobins - physiology</subject><subject>Heart attacks</subject><subject>heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Transplantation</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron - physiology</subject><subject>Lipid peroxidation</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - blood</subject><subject>Oxidation</subject><subject>percutaneous intervention</subject><subject>Permeability</subject><subject>Polymorphism</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>restenosis</subject><subject>vascular inflammation</subject><subject>vitamin E</subject><issn>1479-6678</issn><issn>1744-8298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LxDAQhoMorq4evUrBc3SSfiTxJou6woIXPYc0mUKWbbsmrbD_3pSu3jzlHXjmDfMQcsPgnnMmHhprKAdWUQCQJ-SCiaKgkit5mnIhFK0qIRfkMsYtQC4UU-dkwQVPmbELItb7x8x0me-anWlbM_ThkAbn7RRTyqwJzvffJtpxZ0LmfEQT8YqcNWYX8fr4Lsnny_PHak03769vq6cNtal_oFwUhjmHANY56RpgxnGpCqPKWtQliNwq5eo6RwusKZUDWcmyAIV1JbDEfEnu5t596L9GjIPe9mPo0peap3VWqHRIouhM2dDHGLDR--BbEw6agZ406aRJT5r0pCnxt8fWsW7R_dG_XhKgZqAZhzFgtB47i3qe0oa3vsN_yn8AaAl1qA</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Graves, Karen L</creator><creator>Vigerust, David J</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20160701</creationdate><title>Hp: an inflammatory indicator in cardiovascular disease</title><author>Graves, Karen L ; Vigerust, David J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-274a1dde00cdd8df01ad2894a95b7b5073c99dbb3ec01f59d08685409eb67e5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antioxidants</topic><topic>Atherosclerosis - blood</topic><topic>Binding sites</topic><topic>Biomarkers - blood</topic><topic>cardiac transplant</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Enzymes</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Graft Rejection - blood</topic><topic>haptoglobin</topic><topic>Haptoglobins - genetics</topic><topic>Haptoglobins - physiology</topic><topic>Heart attacks</topic><topic>heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart Transplantation</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Iron</topic><topic>Iron - physiology</topic><topic>Lipid peroxidation</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - blood</topic><topic>Oxidation</topic><topic>percutaneous intervention</topic><topic>Permeability</topic><topic>Polymorphism</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>restenosis</topic><topic>vascular inflammation</topic><topic>vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graves, Karen L</creatorcontrib><creatorcontrib>Vigerust, David J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Future cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graves, Karen L</au><au>Vigerust, David J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hp: an inflammatory indicator in cardiovascular disease</atitle><jtitle>Future cardiology</jtitle><addtitle>Future Cardiol</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>12</volume><issue>4</issue><spage>471</spage><epage>481</epage><pages>471-481</pages><issn>1479-6678</issn><eissn>1744-8298</eissn><abstract>Over the past decade significant advancement has occurred in the biological and pathological role that Hp has in cardiovascular disease. Hp is an acute-phase protein with a role in the neutralization and clearance of free heme. Iron has tremendous potential for initiating vascular oxidation, inflammation and exacerbating coronary atherosclerosis. Hp genotype has been linked as a prognostic biomarker of acute myocardial infarction, heart failure, restenosis and cardiac transplant rejection. The increased understanding of Hp as a biomarker has provided new insights into the mechanisms of inflammation after cardiac injury and support the concept that Hp is not only an important antioxidant in vascular inflammation and atherosclerosis, but also an enhancer of inflammation in cardiac transplant.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>27203711</pmid><doi>10.2217/fca-2016-0008</doi><tpages>11</tpages></addata></record> |
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| language | eng |
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| subjects | Antioxidants Atherosclerosis - blood Binding sites Biomarkers - blood cardiac transplant Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cytokines Diabetes Enzymes Genotype Genotype & phenotype Graft Rejection - blood haptoglobin Haptoglobins - genetics Haptoglobins - physiology Heart attacks heart failure Heart Failure - blood Heart Transplantation Hemoglobin Humans Iron Iron - physiology Lipid peroxidation myocardial infarction Myocardial Infarction - blood Oxidation percutaneous intervention Permeability Polymorphism Prognosis Proteins restenosis vascular inflammation vitamin E |
| title | Hp: an inflammatory indicator in cardiovascular disease |
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