Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats

An increase in oxidative stress is an important pathological mechanism of heart injury induced by doxorubicin (DOX). Tranilast is an anti-allergy drug that has been shown to possess good antioxidant activity in previous studies. The overexpression and secretion of chymase by mast cells (MCs) increas...

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Veröffentlicht in:	Life sciences (1973) 2021-02, Vol.267, p.118984, Article 118984
Hauptverfasser:	Zhan, Chengchuang, Bai, Nan, Zheng, Min, Wang, Yanyan, Wang, Yuanqi, Zhang, Li, Li, Jianqiang, Li, Guangnan, Zhao, Hongyan, Liu, Guangzhong, Lou, Qi, Yang, Wen, Li, Tiankai, Li, Luyifei, Li, Weimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Angiotensin Angiotensin II Angiotensin II - biosynthesis Angiotensin II - drug effects Angiotensin II - metabolism Animals Anthranilic acid antioxidant activity Antioxidants Antioxidants - pharmacology Apoptosis Cardiomegaly - drug therapy Cardiomegaly - metabolism Cardiovascular diseases Chymase Coronary artery disease Deterioration Doxorubicin Doxorubicin - adverse effects Doxorubicin - pharmacology Fibrosis heart Heart diseases Heart Diseases - etiology Heart function Hypertrophy Male males Mast cells Mast Cells - drug effects Myocardial hypertrophy Myocardium - metabolism ortho-Aminobenzoates - metabolism ortho-Aminobenzoates - pharmacology Oxidative stress Oxidative Stress - drug effects protective effect Rats Rats, Wistar secretion stabilizers Synthesis Tranilast
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