Co-exposure of Bi2O3 nanoparticles and bezo[a]pyrene-enhanced in vitro cytotoxicity of mouse spermatogonia cells
Recent attention has been focused on reproductive toxicity of nanoscale materials in combination with pre-existing environmental pollutants. Due to its unique characteristics, bismuth (III) oxide (Bi 2 O 3 ) nanoparticles (BONPs) are being used in diverse fields including cosmetics and biomedicine....
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| Veröffentlicht in: | Environmental science and pollution research international 2021-04, Vol.28 (14), p.17109-17118 |
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| creator | Ahamed, Maqusood Akhtar, Mohd Javed Khan, Mohd Abdul Majeed Alhadlaq, Hisham Abdulaziz |
| description | Recent attention has been focused on reproductive toxicity of nanoscale materials in combination with pre-existing environmental pollutants. Due to its unique characteristics, bismuth (III) oxide (Bi
2
O
3
) nanoparticles (BONPs) are being used in diverse fields including cosmetics and biomedicine. Benzo[a]pyrene (BaP) is a known endocrine disruptor that most common sources of BaP exposure to humans are cigarette smoke and well-cooked barbecued meat. Hence, joint exposure of BONPs and BaP in humans is common. There is scarcity of information on toxicity of BONPs in combination with BaP in human reproductive system. In this work, combined effects of BONPs and BaP in mouse spermatogonia (GC-1 spg) cells were assessed. Results showed that combined exposure of BONPs and BaP synergistically induced cell viability reduction, lactate dehydrogenase leakage, induction of caspases (-3 and -9) and mitochondrial membrane potential loss in GC-1 spg cells. Co-exposure of BONPs and BaP also synergistically induced production of pro-oxidants (reactive oxygen species and hydrogen peroxide) and reduction of antioxidants (glutathione and several antioxidant enzymes). Experiments with N-acetyl-cysteine (NAC, a reactive oxygen species scavenger) indicated that oxidative stress was a plausible mechanism of synergistic toxicity of BONPs and BaP in GC-1 spg cells. Present data could be helpful for future
in vivo
research and risk assessment of human reproductive system co-exposed to BONPs and BaP. |
| doi_str_mv | 10.1007/s11356-020-12128-6 |
| format | Article |
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2
O
3
) nanoparticles (BONPs) are being used in diverse fields including cosmetics and biomedicine. Benzo[a]pyrene (BaP) is a known endocrine disruptor that most common sources of BaP exposure to humans are cigarette smoke and well-cooked barbecued meat. Hence, joint exposure of BONPs and BaP in humans is common. There is scarcity of information on toxicity of BONPs in combination with BaP in human reproductive system. In this work, combined effects of BONPs and BaP in mouse spermatogonia (GC-1 spg) cells were assessed. Results showed that combined exposure of BONPs and BaP synergistically induced cell viability reduction, lactate dehydrogenase leakage, induction of caspases (-3 and -9) and mitochondrial membrane potential loss in GC-1 spg cells. Co-exposure of BONPs and BaP also synergistically induced production of pro-oxidants (reactive oxygen species and hydrogen peroxide) and reduction of antioxidants (glutathione and several antioxidant enzymes). Experiments with N-acetyl-cysteine (NAC, a reactive oxygen species scavenger) indicated that oxidative stress was a plausible mechanism of synergistic toxicity of BONPs and BaP in GC-1 spg cells. Present data could be helpful for future
in vivo
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2
O
3
) nanoparticles (BONPs) are being used in diverse fields including cosmetics and biomedicine. Benzo[a]pyrene (BaP) is a known endocrine disruptor that most common sources of BaP exposure to humans are cigarette smoke and well-cooked barbecued meat. Hence, joint exposure of BONPs and BaP in humans is common. There is scarcity of information on toxicity of BONPs in combination with BaP in human reproductive system. In this work, combined effects of BONPs and BaP in mouse spermatogonia (GC-1 spg) cells were assessed. Results showed that combined exposure of BONPs and BaP synergistically induced cell viability reduction, lactate dehydrogenase leakage, induction of caspases (-3 and -9) and mitochondrial membrane potential loss in GC-1 spg cells. Co-exposure of BONPs and BaP also synergistically induced production of pro-oxidants (reactive oxygen species and hydrogen peroxide) and reduction of antioxidants (glutathione and several antioxidant enzymes). Experiments with N-acetyl-cysteine (NAC, a reactive oxygen species scavenger) indicated that oxidative stress was a plausible mechanism of synergistic toxicity of BONPs and BaP in GC-1 spg cells. Present data could be helpful for future
in vivo
research and risk assessment of human reproductive system co-exposed to BONPs and BaP.</description><subject>Acetylcysteine</subject><subject>Antioxidants</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Benzo(a)pyrene</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bismuth oxides</subject><subject>Bismuth trioxide</subject><subject>Cell viability</subject><subject>Cigarette smoke</subject><subject>Cosmetics</subject><subject>Cytotoxicity</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Endocrine disruptors</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Exposure</subject><subject>Glutathione</subject><subject>Guanylate cyclase</subject><subject>Hydrogen peroxide</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Meat</subject><subject>Membrane potential</subject><subject>Mitochondria</subject><subject>Nanoparticles</subject><subject>Oxidants</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Oxidizing agents</subject><subject>Pollutants</subject><subject>Pyrene</subject><subject>Reactive oxygen species</subject><subject>Reduction</subject><subject>Reproductive system</subject><subject>Research Article</subject><subject>Risk assessment</subject><subject>Spermatogonia</subject><subject>Toxicity</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution 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Abdulaziz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-exposure of Bi2O3 nanoparticles and bezo[a]pyrene-enhanced in vitro cytotoxicity of mouse spermatogonia cells</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><date>2021-04-01</date><risdate>2021</risdate><volume>28</volume><issue>14</issue><spage>17109</spage><epage>17118</epage><pages>17109-17118</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Recent attention has been focused on reproductive toxicity of nanoscale materials in combination with pre-existing environmental pollutants. Due to its unique characteristics, bismuth (III) oxide (Bi
2
O
3
) nanoparticles (BONPs) are being used in diverse fields including cosmetics and biomedicine. Benzo[a]pyrene (BaP) is a known endocrine disruptor that most common sources of BaP exposure to humans are cigarette smoke and well-cooked barbecued meat. Hence, joint exposure of BONPs and BaP in humans is common. There is scarcity of information on toxicity of BONPs in combination with BaP in human reproductive system. In this work, combined effects of BONPs and BaP in mouse spermatogonia (GC-1 spg) cells were assessed. Results showed that combined exposure of BONPs and BaP synergistically induced cell viability reduction, lactate dehydrogenase leakage, induction of caspases (-3 and -9) and mitochondrial membrane potential loss in GC-1 spg cells. Co-exposure of BONPs and BaP also synergistically induced production of pro-oxidants (reactive oxygen species and hydrogen peroxide) and reduction of antioxidants (glutathione and several antioxidant enzymes). Experiments with N-acetyl-cysteine (NAC, a reactive oxygen species scavenger) indicated that oxidative stress was a plausible mechanism of synergistic toxicity of BONPs and BaP in GC-1 spg cells. Present data could be helpful for future
in vivo
research and risk assessment of human reproductive system co-exposed to BONPs and BaP.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s11356-020-12128-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6025-1950</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Environmental science and pollution research international, 2021-04, Vol.28 (14), p.17109-17118 |
| issn | 0944-1344 1614-7499 |
| language | eng |
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| subjects | Acetylcysteine Antioxidants Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Benzo(a)pyrene Biocompatibility Biomedical materials Bismuth oxides Bismuth trioxide Cell viability Cigarette smoke Cosmetics Cytotoxicity Earth and Environmental Science Ecotoxicology Endocrine disruptors Environment Environmental Chemistry Environmental Health Environmental science Exposure Glutathione Guanylate cyclase Hydrogen peroxide L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Meat Membrane potential Mitochondria Nanoparticles Oxidants Oxidation Oxidative stress Oxidizing agents Pollutants Pyrene Reactive oxygen species Reduction Reproductive system Research Article Risk assessment Spermatogonia Toxicity Waste Water Technology Water Management Water Pollution Control |
| title | Co-exposure of Bi2O3 nanoparticles and bezo[a]pyrene-enhanced in vitro cytotoxicity of mouse spermatogonia cells |
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