Flavonoids potentiated anticancer activity of cisplatin in non-small cell lung cancer cells in vitro by inhibiting histone deacetylases

Cisplatin is the mainstay of first-line treatment for advanced non-small cell lung cancer (NSCLC). Accumulating evidence suggests that flavonoids inhibit histone deacetylase (HDAC) to mediate their anticancer effect in various cancer types. The study was conducted to investigate the inhibition of HD...

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Veröffentlicht in:	Life sciences (1973) 2020-10, Vol.258, p.118211, Article 118211
Hauptverfasser:	Yan, Wei, Wu, Tracy H.Y., Leung, Sharon S.Y., To, Kenneth K.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Anticancer properties Antitumor activity Apigenin Apoptosis Assaying Binding Cell cycle Chromatin Cisplatin Cyclin-dependent kinase inhibitor p21 Cytotoxicity DNA-directed RNA polymerase Flavonoids Flow cytometry Genes Histone deacetylase Histone deacetylases Histones Immunoprecipitation Lung cancer Non-small cell lung cancer Non-small cell lung carcinoma p53 Protein Prolongation Promoters RNA polymerase RNA polymerase II S phase Small cell lung carcinoma Sp1 protein Sulforhodamine Toxicity Transcription factors
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