Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats

[Display omitted] •OXL induced oxidative stress while LY reduced it, in brain tissue.•OXL exposure triggered apoptosis whereas LY reduced it, in both the brain and sciatic nerve tissue.•OXL caused inflammation, but LY reduced it, in both the brain and sciatic nerve tissue.•OXL exposure caused ER str...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2020-09, Vol.80, p.29-40
Hauptverfasser:	Celik, Hamit, Kucukler, Sefa, Ozdemir, Selcuk, Comakli, Selim, Gur, Cihan, Kandemir, Fatih Mehmet, Yardim, Ahmet
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Antioxidants Apoptosis Brain Brain damage Brain injury Brain-derived neurotrophic factor Caspase-3 Catalase eIF-2 kinase Endoplasmic reticulum Endoplasmic reticulum stress Glial fibrillary acidic protein Glutathione Glutathione peroxidase Inflammation Inositol Kinases Lipid peroxidation Lipids Lycopene MAP kinase Neural cell adhesion molecule Neuropathy NF-κB protein Oral administration Oxaliplatin Oxidative stress Peripheral nerves Peripheral neuropathy Peroxidase Peroxidation Platinum Protein kinase Proteins Superoxide dismutase Tumor necrosis factor-TNF
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