MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning
•Necrosis of basal ganglia are the typical MRI finding in survivors of methanol poisoning.•Survivors with toxic brain damage had lower volume of basal ganglia.•Positive correlation between the volume of putamen, markers of severity of poisoning.•Correlation between the basal ganglia volume and the t...
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| creator | Hlusicka, Jiri Mana, Josef Vaneckova, Manuela Kotikova, Katerina Diblik, Pavel Urban, Pavel Navratil, Tomas Marechal, Benedicte Kober, Tobias Zakharov, Sergey |
| description | •Necrosis of basal ganglia are the typical MRI finding in survivors of methanol poisoning.•Survivors with toxic brain damage had lower volume of basal ganglia.•Positive correlation between the volume of putamen, markers of severity of poisoning.•Correlation between the basal ganglia volume and the thickness of retinal nerve fibers layer.
Basal ganglia lesions are typical findings on magnetic resonance imaging (MRI) of the brain in survivors of acute methanol poisoning. However, no data are available on the association between the magnitude of damaged brain regions, serum concentrations of markers of acute methanol toxicity, oxidative stress, neuroinflammation, and the rate of retinal nerve ganglion cell loss.
To investigate the association between MRI-based volumetry of the basal ganglia, retinal nerve fibre layer (RNFL) thickness and prognostic laboratory markers of outcomes in acute methanol poisoning.
MRI-based volumetry of putamen, nucleus caudatus and globus pallidus was performed and compared with laboratory parameters of severity of poisoning and acute serum markers of oxidative damage of lipids (8-isoprostan, MDA, HHE, HNE), nucleic acids (8−OHdG, 8−OHG, 5−OHMU), proteins (o-Thyr, NO-Thyr, Cl-Thyr) and leukotrienes (LTC4, LTD4, LTE4, LTB4), as well as with the results of RNFL measurements by optic coherence tomography (OCT) in 16 patients with acute methanol poisoning (Group I) and in 28 survivors of poisoning two years after discharge with the same markers measured within the follow-up examination (Group II). The control group consisted of 28 healthy subjects without methanol poisoning.
The survivors of acute methanol poisoning had significantly lower volumes of basal ganglia than the controls. The patients with MRI signs of methanol-induced toxic brain damage had significantly lower volumes of basal ganglia than those without these signs. A positive correlation was found between the volume of putamen and arterial blood pH on admission (r = 0.45; p = 0.02 and r = 0.44; p = 0.02 for left and right putamen, correspondingly). A negative correlation was present between the volumes of putamen and acute serum lactate (r = -0.63; p |
| doi_str_mv | 10.1016/j.neuro.2020.06.006 |
| format | Article |
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Basal ganglia lesions are typical findings on magnetic resonance imaging (MRI) of the brain in survivors of acute methanol poisoning. However, no data are available on the association between the magnitude of damaged brain regions, serum concentrations of markers of acute methanol toxicity, oxidative stress, neuroinflammation, and the rate of retinal nerve ganglion cell loss.
To investigate the association between MRI-based volumetry of the basal ganglia, retinal nerve fibre layer (RNFL) thickness and prognostic laboratory markers of outcomes in acute methanol poisoning.
MRI-based volumetry of putamen, nucleus caudatus and globus pallidus was performed and compared with laboratory parameters of severity of poisoning and acute serum markers of oxidative damage of lipids (8-isoprostan, MDA, HHE, HNE), nucleic acids (8−OHdG, 8−OHG, 5−OHMU), proteins (o-Thyr, NO-Thyr, Cl-Thyr) and leukotrienes (LTC4, LTD4, LTE4, LTB4), as well as with the results of RNFL measurements by optic coherence tomography (OCT) in 16 patients with acute methanol poisoning (Group I) and in 28 survivors of poisoning two years after discharge with the same markers measured within the follow-up examination (Group II). The control group consisted of 28 healthy subjects without methanol poisoning.
The survivors of acute methanol poisoning had significantly lower volumes of basal ganglia than the controls. The patients with MRI signs of methanol-induced toxic brain damage had significantly lower volumes of basal ganglia than those without these signs. A positive correlation was found between the volume of putamen and arterial blood pH on admission (r = 0.45; p = 0.02 and r = 0.44; p = 0.02 for left and right putamen, correspondingly). A negative correlation was present between the volumes of putamen and acute serum lactate (r = -0.63; p < 0.001 and r = -0.59; p = 0.01), creatinine (r = -0.53; p = 0.01 and r = -0.47; p = 0.01) and glucose (r = -0.55; p < 0.001 and r = -0.50; p = 0.01) concentrations.
The volume of basal ganglia positively correlated with acute concentrations of markers of lipoperoxidation (8-isoprostan: r = 0.61; p < 0.05 and r = 0.59; p < 0.05 for left and right putamen, correspondingly) and inflammation (leukotriene LTB4: r = 0.61; p < 0.05 and r = 0.61; p < 0.05 for left and right putamen, correspondingly). The higher the volume of the basal ganglia, the higher the thickness of the RNFL, with the strongest positive association between global RNFL and the volume of putamen bilaterally (all p < 0.01). In the follow-up markers of oxidative stress and inflammation, only o-Thyr concentration negatively correlated with the volume of putamen bilaterally (r = –0.39; p < 0.05 and r = –0.37; p < 0.05 for left and right putamen, correspondingly).
In survivors of acute methanol poisoning with signs of toxic brain damage, the magnitude of affected areas correlated with acute parameters of severity of poisoning, markers of oxidative stress and neuroinflammation. There was a positive association between the basal ganglia volume and the thickness of RNFL, making OCT an important screening test and MRI-based volumetry the confirmative diagnostic method for the detection of CNS sequelae of methanol poisoning.]]></description><identifier>ISSN: 0161-813X</identifier><identifier>EISSN: 1872-9711</identifier><identifier>DOI: 10.1016/j.neuro.2020.06.006</identifier><language>eng</language><publisher>Redfield: Elsevier B.V</publisher><subject>8-Hydroxydeoxyguanosine ; Basal ganglia ; Biomarkers ; Brain ; Brain damage ; Brain injury ; Complications ; Correlation ; Creatinine ; Ganglia ; Globus pallidus ; Inflammation ; Laboratories ; Lactic acid ; Leukotrienes ; Lipids ; Long-term CNS sequelae ; Magnetic resonance imaging ; Methanol ; Methanol toxicity ; Neuroimaging ; Nucleic acids ; Optical Coherence Tomography ; Oxidative stress ; Parameters ; Poisoning ; Prognostic parameters ; Putamen ; Retina ; Survival ; Thickness ; Tomography ; Toxic brain damage ; Toxicity</subject><ispartof>Neurotoxicology (Park Forest South), 2020-09, Vol.80, p.12-19</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright Elsevier BV Sep 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-7ed65cf55acbcd95e7d34a18a1019ae40d2a6d9e10b556cff97cd44916b085e23</citedby><cites>FETCH-LOGICAL-c364t-7ed65cf55acbcd95e7d34a18a1019ae40d2a6d9e10b556cff97cd44916b085e23</cites><orcidid>0000-0002-7817-3978</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161813X20300930$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Hlusicka, Jiri</creatorcontrib><creatorcontrib>Mana, Josef</creatorcontrib><creatorcontrib>Vaneckova, Manuela</creatorcontrib><creatorcontrib>Kotikova, Katerina</creatorcontrib><creatorcontrib>Diblik, Pavel</creatorcontrib><creatorcontrib>Urban, Pavel</creatorcontrib><creatorcontrib>Navratil, Tomas</creatorcontrib><creatorcontrib>Marechal, Benedicte</creatorcontrib><creatorcontrib>Kober, Tobias</creatorcontrib><creatorcontrib>Zakharov, Sergey</creatorcontrib><title>MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning</title><title>Neurotoxicology (Park Forest South)</title><description><![CDATA[•Necrosis of basal ganglia are the typical MRI finding in survivors of methanol poisoning.•Survivors with toxic brain damage had lower volume of basal ganglia.•Positive correlation between the volume of putamen, markers of severity of poisoning.•Correlation between the basal ganglia volume and the thickness of retinal nerve fibers layer.
Basal ganglia lesions are typical findings on magnetic resonance imaging (MRI) of the brain in survivors of acute methanol poisoning. However, no data are available on the association between the magnitude of damaged brain regions, serum concentrations of markers of acute methanol toxicity, oxidative stress, neuroinflammation, and the rate of retinal nerve ganglion cell loss.
To investigate the association between MRI-based volumetry of the basal ganglia, retinal nerve fibre layer (RNFL) thickness and prognostic laboratory markers of outcomes in acute methanol poisoning.
MRI-based volumetry of putamen, nucleus caudatus and globus pallidus was performed and compared with laboratory parameters of severity of poisoning and acute serum markers of oxidative damage of lipids (8-isoprostan, MDA, HHE, HNE), nucleic acids (8−OHdG, 8−OHG, 5−OHMU), proteins (o-Thyr, NO-Thyr, Cl-Thyr) and leukotrienes (LTC4, LTD4, LTE4, LTB4), as well as with the results of RNFL measurements by optic coherence tomography (OCT) in 16 patients with acute methanol poisoning (Group I) and in 28 survivors of poisoning two years after discharge with the same markers measured within the follow-up examination (Group II). The control group consisted of 28 healthy subjects without methanol poisoning.
The survivors of acute methanol poisoning had significantly lower volumes of basal ganglia than the controls. The patients with MRI signs of methanol-induced toxic brain damage had significantly lower volumes of basal ganglia than those without these signs. A positive correlation was found between the volume of putamen and arterial blood pH on admission (r = 0.45; p = 0.02 and r = 0.44; p = 0.02 for left and right putamen, correspondingly). A negative correlation was present between the volumes of putamen and acute serum lactate (r = -0.63; p < 0.001 and r = -0.59; p = 0.01), creatinine (r = -0.53; p = 0.01 and r = -0.47; p = 0.01) and glucose (r = -0.55; p < 0.001 and r = -0.50; p = 0.01) concentrations.
The volume of basal ganglia positively correlated with acute concentrations of markers of lipoperoxidation (8-isoprostan: r = 0.61; p < 0.05 and r = 0.59; p < 0.05 for left and right putamen, correspondingly) and inflammation (leukotriene LTB4: r = 0.61; p < 0.05 and r = 0.61; p < 0.05 for left and right putamen, correspondingly). The higher the volume of the basal ganglia, the higher the thickness of the RNFL, with the strongest positive association between global RNFL and the volume of putamen bilaterally (all p < 0.01). In the follow-up markers of oxidative stress and inflammation, only o-Thyr concentration negatively correlated with the volume of putamen bilaterally (r = –0.39; p < 0.05 and r = –0.37; p < 0.05 for left and right putamen, correspondingly).
In survivors of acute methanol poisoning with signs of toxic brain damage, the magnitude of affected areas correlated with acute parameters of severity of poisoning, markers of oxidative stress and neuroinflammation. There was a positive association between the basal ganglia volume and the thickness of RNFL, making OCT an important screening test and MRI-based volumetry the confirmative diagnostic method for the detection of CNS sequelae of methanol poisoning.]]></description><subject>8-Hydroxydeoxyguanosine</subject><subject>Basal ganglia</subject><subject>Biomarkers</subject><subject>Brain</subject><subject>Brain damage</subject><subject>Brain injury</subject><subject>Complications</subject><subject>Correlation</subject><subject>Creatinine</subject><subject>Ganglia</subject><subject>Globus pallidus</subject><subject>Inflammation</subject><subject>Laboratories</subject><subject>Lactic acid</subject><subject>Leukotrienes</subject><subject>Lipids</subject><subject>Long-term CNS sequelae</subject><subject>Magnetic resonance imaging</subject><subject>Methanol</subject><subject>Methanol toxicity</subject><subject>Neuroimaging</subject><subject>Nucleic acids</subject><subject>Optical Coherence Tomography</subject><subject>Oxidative stress</subject><subject>Parameters</subject><subject>Poisoning</subject><subject>Prognostic parameters</subject><subject>Putamen</subject><subject>Retina</subject><subject>Survival</subject><subject>Thickness</subject><subject>Tomography</subject><subject>Toxic brain damage</subject><subject>Toxicity</subject><issn>0161-813X</issn><issn>1872-9711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kM1KxDAYRYMoOP48gZuA69akbZLpwoWIf6AIouAupMlXJ-NMv5qkgvjyZhzXru7m3Av3EHLCWckZl2fLcoApYFmxipVMlozJHTLjc1UVreJ8l8wyxYs5r1_3yUGMS8a4ULKdke-Hp7uiMxEc7YLxA_3E1bSGFL6oGRwNkPxgVhTH5G1OiwsIMFigCdf4Fsy4yGCkaQG087g24R1CpNhTnJLFNdA8aeyUgObRhRlwRUf0EQc_vB2Rvd6sIhz_5SF5ub56vrwt7h9v7i4v7gtbyyYVCpwUthfC2M66VoBydWP43OTrrYGGucpI1wJnnRDS9n2rrGualsuOzQVU9SE53e6OAT8miEkvcQr5VtSVYEJVvFYqU_WWsgFjDNDrMfh86EtzpjeW9VL_WtYby5pJnS3n1vm2BfnAp4ego_UbQc4HsEk79P_2fwC2b4nE</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Hlusicka, Jiri</creator><creator>Mana, Josef</creator><creator>Vaneckova, Manuela</creator><creator>Kotikova, Katerina</creator><creator>Diblik, Pavel</creator><creator>Urban, Pavel</creator><creator>Navratil, Tomas</creator><creator>Marechal, Benedicte</creator><creator>Kober, Tobias</creator><creator>Zakharov, Sergey</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><orcidid>https://orcid.org/0000-0002-7817-3978</orcidid></search><sort><creationdate>202009</creationdate><title>MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning</title><author>Hlusicka, Jiri ; Mana, Josef ; Vaneckova, Manuela ; Kotikova, Katerina ; Diblik, Pavel ; Urban, Pavel ; Navratil, Tomas ; Marechal, Benedicte ; Kober, Tobias ; Zakharov, Sergey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-7ed65cf55acbcd95e7d34a18a1019ae40d2a6d9e10b556cff97cd44916b085e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>8-Hydroxydeoxyguanosine</topic><topic>Basal ganglia</topic><topic>Biomarkers</topic><topic>Brain</topic><topic>Brain damage</topic><topic>Brain injury</topic><topic>Complications</topic><topic>Correlation</topic><topic>Creatinine</topic><topic>Ganglia</topic><topic>Globus pallidus</topic><topic>Inflammation</topic><topic>Laboratories</topic><topic>Lactic acid</topic><topic>Leukotrienes</topic><topic>Lipids</topic><topic>Long-term CNS sequelae</topic><topic>Magnetic resonance imaging</topic><topic>Methanol</topic><topic>Methanol toxicity</topic><topic>Neuroimaging</topic><topic>Nucleic acids</topic><topic>Optical Coherence Tomography</topic><topic>Oxidative stress</topic><topic>Parameters</topic><topic>Poisoning</topic><topic>Prognostic parameters</topic><topic>Putamen</topic><topic>Retina</topic><topic>Survival</topic><topic>Thickness</topic><topic>Tomography</topic><topic>Toxic brain damage</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hlusicka, Jiri</creatorcontrib><creatorcontrib>Mana, Josef</creatorcontrib><creatorcontrib>Vaneckova, Manuela</creatorcontrib><creatorcontrib>Kotikova, Katerina</creatorcontrib><creatorcontrib>Diblik, Pavel</creatorcontrib><creatorcontrib>Urban, Pavel</creatorcontrib><creatorcontrib>Navratil, Tomas</creatorcontrib><creatorcontrib>Marechal, Benedicte</creatorcontrib><creatorcontrib>Kober, Tobias</creatorcontrib><creatorcontrib>Zakharov, Sergey</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neurotoxicology (Park Forest South)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hlusicka, Jiri</au><au>Mana, Josef</au><au>Vaneckova, Manuela</au><au>Kotikova, Katerina</au><au>Diblik, Pavel</au><au>Urban, Pavel</au><au>Navratil, Tomas</au><au>Marechal, Benedicte</au><au>Kober, Tobias</au><au>Zakharov, Sergey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning</atitle><jtitle>Neurotoxicology (Park Forest South)</jtitle><date>2020-09</date><risdate>2020</risdate><volume>80</volume><spage>12</spage><epage>19</epage><pages>12-19</pages><issn>0161-813X</issn><eissn>1872-9711</eissn><abstract><![CDATA[•Necrosis of basal ganglia are the typical MRI finding in survivors of methanol poisoning.•Survivors with toxic brain damage had lower volume of basal ganglia.•Positive correlation between the volume of putamen, markers of severity of poisoning.•Correlation between the basal ganglia volume and the thickness of retinal nerve fibers layer.
Basal ganglia lesions are typical findings on magnetic resonance imaging (MRI) of the brain in survivors of acute methanol poisoning. However, no data are available on the association between the magnitude of damaged brain regions, serum concentrations of markers of acute methanol toxicity, oxidative stress, neuroinflammation, and the rate of retinal nerve ganglion cell loss.
To investigate the association between MRI-based volumetry of the basal ganglia, retinal nerve fibre layer (RNFL) thickness and prognostic laboratory markers of outcomes in acute methanol poisoning.
MRI-based volumetry of putamen, nucleus caudatus and globus pallidus was performed and compared with laboratory parameters of severity of poisoning and acute serum markers of oxidative damage of lipids (8-isoprostan, MDA, HHE, HNE), nucleic acids (8−OHdG, 8−OHG, 5−OHMU), proteins (o-Thyr, NO-Thyr, Cl-Thyr) and leukotrienes (LTC4, LTD4, LTE4, LTB4), as well as with the results of RNFL measurements by optic coherence tomography (OCT) in 16 patients with acute methanol poisoning (Group I) and in 28 survivors of poisoning two years after discharge with the same markers measured within the follow-up examination (Group II). The control group consisted of 28 healthy subjects without methanol poisoning.
The survivors of acute methanol poisoning had significantly lower volumes of basal ganglia than the controls. The patients with MRI signs of methanol-induced toxic brain damage had significantly lower volumes of basal ganglia than those without these signs. A positive correlation was found between the volume of putamen and arterial blood pH on admission (r = 0.45; p = 0.02 and r = 0.44; p = 0.02 for left and right putamen, correspondingly). A negative correlation was present between the volumes of putamen and acute serum lactate (r = -0.63; p < 0.001 and r = -0.59; p = 0.01), creatinine (r = -0.53; p = 0.01 and r = -0.47; p = 0.01) and glucose (r = -0.55; p < 0.001 and r = -0.50; p = 0.01) concentrations.
The volume of basal ganglia positively correlated with acute concentrations of markers of lipoperoxidation (8-isoprostan: r = 0.61; p < 0.05 and r = 0.59; p < 0.05 for left and right putamen, correspondingly) and inflammation (leukotriene LTB4: r = 0.61; p < 0.05 and r = 0.61; p < 0.05 for left and right putamen, correspondingly). The higher the volume of the basal ganglia, the higher the thickness of the RNFL, with the strongest positive association between global RNFL and the volume of putamen bilaterally (all p < 0.01). In the follow-up markers of oxidative stress and inflammation, only o-Thyr concentration negatively correlated with the volume of putamen bilaterally (r = –0.39; p < 0.05 and r = –0.37; p < 0.05 for left and right putamen, correspondingly).
In survivors of acute methanol poisoning with signs of toxic brain damage, the magnitude of affected areas correlated with acute parameters of severity of poisoning, markers of oxidative stress and neuroinflammation. There was a positive association between the basal ganglia volume and the thickness of RNFL, making OCT an important screening test and MRI-based volumetry the confirmative diagnostic method for the detection of CNS sequelae of methanol poisoning.]]></abstract><cop>Redfield</cop><pub>Elsevier B.V</pub><doi>10.1016/j.neuro.2020.06.006</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7817-3978</orcidid></addata></record> |
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| ispartof | Neurotoxicology (Park Forest South), 2020-09, Vol.80, p.12-19 |
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| subjects | 8-Hydroxydeoxyguanosine Basal ganglia Biomarkers Brain Brain damage Brain injury Complications Correlation Creatinine Ganglia Globus pallidus Inflammation Laboratories Lactic acid Leukotrienes Lipids Long-term CNS sequelae Magnetic resonance imaging Methanol Methanol toxicity Neuroimaging Nucleic acids Optical Coherence Tomography Oxidative stress Parameters Poisoning Prognostic parameters Putamen Retina Survival Thickness Tomography Toxic brain damage Toxicity |
| title | MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning |
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