Associating physiological functions with genomic variability in hibernating bats
The challenges of surviving periods of increased physiological stress elicit selective pressures that drive adaptations to overcome hardships. Bats in the Palearctic region survive winter in hibernation. We sampled single nucleotide polymorphisms (SNPs) in hibernating Myotis myotis bats using double...
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| Veröffentlicht in: | Evolutionary ecology 2021-04, Vol.35 (2), p.291-308 |
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| creator | Harazim, Markéta Piálek, Lubomír Pikula, Jiri Seidlová, Veronika Zukal, Jan Bachorec, Erik Bartonička, Tomáš Kokurewicz, Tomasz Martínková, Natália |
| description | The challenges of surviving periods of increased physiological stress elicit selective pressures that drive adaptations to overcome hardships. Bats in the Palearctic region survive winter in hibernation. We sampled single nucleotide polymorphisms (SNPs) in hibernating
Myotis myotis
bats using double-digest restriction site-associated DNA sequencing and we associated the genomic variability with the observed phenotypes reflecting hibernation site preference, body condition and bat health during hibernation. We did not observe genotype associations between the detrended body condition index, representing fat reserves, and functional genes involved in fat metabolism. Bat body surface temperature, reflecting roost selection, or roost warmth relative to the climate at the site did not show any associations with the sampled genotypes. We found SNPs with associations to macroclimatic variables, characterising the hibernaculum, and blood biochemistry, related to health of the bat. The genes in proximity of the associated SNPs were involved in metabolism, immune response and signal transduction, including chaperones, apoptosis and autophagy regulators and immune signalling molecules. The genetic adaptations included adaptation to tissue repair and protection against tissue damage. |
| doi_str_mv | 10.1007/s10682-020-10096-4 |
| format | Article |
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Myotis myotis
bats using double-digest restriction site-associated DNA sequencing and we associated the genomic variability with the observed phenotypes reflecting hibernation site preference, body condition and bat health during hibernation. We did not observe genotype associations between the detrended body condition index, representing fat reserves, and functional genes involved in fat metabolism. Bat body surface temperature, reflecting roost selection, or roost warmth relative to the climate at the site did not show any associations with the sampled genotypes. We found SNPs with associations to macroclimatic variables, characterising the hibernaculum, and blood biochemistry, related to health of the bat. The genes in proximity of the associated SNPs were involved in metabolism, immune response and signal transduction, including chaperones, apoptosis and autophagy regulators and immune signalling molecules. The genetic adaptations included adaptation to tissue repair and protection against tissue damage.</description><identifier>ISSN: 0269-7653</identifier><identifier>EISSN: 1573-8477</identifier><identifier>DOI: 10.1007/s10682-020-10096-4</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adaptation ; Animal Ecology ; Apoptosis ; Autophagy ; Biomedical and Life Sciences ; Body temperature ; Cellular signal transduction ; Chaperones ; Chiroptera ; Chromosomes ; Deoxyribonucleic acid ; DNA ; DNA sequencing ; Ecology ; Evolutionary Biology ; Fat metabolism ; Genes ; Genomics ; Genotypes ; Hibernation ; Immune response ; Immune system ; Life Sciences ; Metabolism ; Nucleotides ; Original Paper ; Phagocytosis ; Phenotypes ; Physiological aspects ; Physiology ; Plant Sciences ; Regulators ; Signal transduction ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Stress (physiology) ; Surface temperature ; Variability</subject><ispartof>Evolutionary ecology, 2021-04, Vol.35 (2), p.291-308</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-ad4445fd74fa86fffef660e9bb033bc8abf9f9446c6d88dfcae9b2403ecf80e03</citedby><cites>FETCH-LOGICAL-c386t-ad4445fd74fa86fffef660e9bb033bc8abf9f9446c6d88dfcae9b2403ecf80e03</cites><orcidid>0000-0002-5791-5338 ; 0000-0001-8747-9365 ; 0000-0003-4967-6880 ; 0000-0002-3906-2124 ; 0000-0003-1881-4646 ; 0000-0003-4556-4363 ; 0000-0002-8208-7589</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10682-020-10096-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10682-020-10096-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,41490,42559,51321</link.rule.ids></links><search><creatorcontrib>Harazim, Markéta</creatorcontrib><creatorcontrib>Piálek, Lubomír</creatorcontrib><creatorcontrib>Pikula, Jiri</creatorcontrib><creatorcontrib>Seidlová, Veronika</creatorcontrib><creatorcontrib>Zukal, Jan</creatorcontrib><creatorcontrib>Bachorec, Erik</creatorcontrib><creatorcontrib>Bartonička, Tomáš</creatorcontrib><creatorcontrib>Kokurewicz, Tomasz</creatorcontrib><creatorcontrib>Martínková, Natália</creatorcontrib><title>Associating physiological functions with genomic variability in hibernating bats</title><title>Evolutionary ecology</title><addtitle>Evol Ecol</addtitle><description>The challenges of surviving periods of increased physiological stress elicit selective pressures that drive adaptations to overcome hardships. Bats in the Palearctic region survive winter in hibernation. We sampled single nucleotide polymorphisms (SNPs) in hibernating
Myotis myotis
bats using double-digest restriction site-associated DNA sequencing and we associated the genomic variability with the observed phenotypes reflecting hibernation site preference, body condition and bat health during hibernation. We did not observe genotype associations between the detrended body condition index, representing fat reserves, and functional genes involved in fat metabolism. Bat body surface temperature, reflecting roost selection, or roost warmth relative to the climate at the site did not show any associations with the sampled genotypes. We found SNPs with associations to macroclimatic variables, characterising the hibernaculum, and blood biochemistry, related to health of the bat. The genes in proximity of the associated SNPs were involved in metabolism, immune response and signal transduction, including chaperones, apoptosis and autophagy regulators and immune signalling molecules. The genetic adaptations included adaptation to tissue repair and protection against tissue damage.</description><subject>Adaptation</subject><subject>Animal Ecology</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Biomedical and Life Sciences</subject><subject>Body temperature</subject><subject>Cellular signal transduction</subject><subject>Chaperones</subject><subject>Chiroptera</subject><subject>Chromosomes</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA sequencing</subject><subject>Ecology</subject><subject>Evolutionary Biology</subject><subject>Fat metabolism</subject><subject>Genes</subject><subject>Genomics</subject><subject>Genotypes</subject><subject>Hibernation</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Life Sciences</subject><subject>Metabolism</subject><subject>Nucleotides</subject><subject>Original Paper</subject><subject>Phagocytosis</subject><subject>Phenotypes</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Plant Sciences</subject><subject>Regulators</subject><subject>Signal transduction</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Stress (physiology)</subject><subject>Surface 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physiological functions with genomic variability in hibernating bats</title><author>Harazim, Markéta ; Piálek, Lubomír ; Pikula, Jiri ; Seidlová, Veronika ; Zukal, Jan ; Bachorec, Erik ; Bartonička, Tomáš ; Kokurewicz, Tomasz ; Martínková, Natália</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-ad4445fd74fa86fffef660e9bb033bc8abf9f9446c6d88dfcae9b2403ecf80e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptation</topic><topic>Animal Ecology</topic><topic>Apoptosis</topic><topic>Autophagy</topic><topic>Biomedical and Life Sciences</topic><topic>Body temperature</topic><topic>Cellular signal transduction</topic><topic>Chaperones</topic><topic>Chiroptera</topic><topic>Chromosomes</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA sequencing</topic><topic>Ecology</topic><topic>Evolutionary Biology</topic><topic>Fat 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harazim, Markéta</au><au>Piálek, Lubomír</au><au>Pikula, Jiri</au><au>Seidlová, Veronika</au><au>Zukal, Jan</au><au>Bachorec, Erik</au><au>Bartonička, Tomáš</au><au>Kokurewicz, Tomasz</au><au>Martínková, Natália</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associating physiological functions with genomic variability in hibernating bats</atitle><jtitle>Evolutionary ecology</jtitle><stitle>Evol Ecol</stitle><date>2021-04-01</date><risdate>2021</risdate><volume>35</volume><issue>2</issue><spage>291</spage><epage>308</epage><pages>291-308</pages><issn>0269-7653</issn><eissn>1573-8477</eissn><abstract>The challenges of surviving periods of increased physiological stress elicit selective pressures that drive adaptations to overcome hardships. Bats in the Palearctic region survive winter in hibernation. We sampled single nucleotide polymorphisms (SNPs) in hibernating
Myotis myotis
bats using double-digest restriction site-associated DNA sequencing and we associated the genomic variability with the observed phenotypes reflecting hibernation site preference, body condition and bat health during hibernation. We did not observe genotype associations between the detrended body condition index, representing fat reserves, and functional genes involved in fat metabolism. Bat body surface temperature, reflecting roost selection, or roost warmth relative to the climate at the site did not show any associations with the sampled genotypes. We found SNPs with associations to macroclimatic variables, characterising the hibernaculum, and blood biochemistry, related to health of the bat. The genes in proximity of the associated SNPs were involved in metabolism, immune response and signal transduction, including chaperones, apoptosis and autophagy regulators and immune signalling molecules. The genetic adaptations included adaptation to tissue repair and protection against tissue damage.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10682-020-10096-4</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-5791-5338</orcidid><orcidid>https://orcid.org/0000-0001-8747-9365</orcidid><orcidid>https://orcid.org/0000-0003-4967-6880</orcidid><orcidid>https://orcid.org/0000-0002-3906-2124</orcidid><orcidid>https://orcid.org/0000-0003-1881-4646</orcidid><orcidid>https://orcid.org/0000-0003-4556-4363</orcidid><orcidid>https://orcid.org/0000-0002-8208-7589</orcidid></addata></record> |
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| subjects | Adaptation Animal Ecology Apoptosis Autophagy Biomedical and Life Sciences Body temperature Cellular signal transduction Chaperones Chiroptera Chromosomes Deoxyribonucleic acid DNA DNA sequencing Ecology Evolutionary Biology Fat metabolism Genes Genomics Genotypes Hibernation Immune response Immune system Life Sciences Metabolism Nucleotides Original Paper Phagocytosis Phenotypes Physiological aspects Physiology Plant Sciences Regulators Signal transduction Single nucleotide polymorphisms Single-nucleotide polymorphism Stress (physiology) Surface temperature Variability |
| title | Associating physiological functions with genomic variability in hibernating bats |
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