Toxicological assessment and developmental abnormalities induced by butylparaben and ethylparaben exposure in zebrafish early-life stages

•Ethylparaben and butylparaben exposure led to acute toxicity in zebrafish embryos.•Determination of BM dose values were performed using model averaging approach.•Developmental alterations were reported.•Zebrafish larvae showed behavioral changes. Toxicological effects of butylparaben (BuP) and ethy...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2020-11, Vol.80, p.103504, Article 103504
Hauptverfasser:	Merola, C., Lai, O., Conte, A., Crescenzo, G., Torelli, T., Alloro, M., Perugini, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acute toxicity test Animals Behavior, Animal - drug effects Benchmark dose Blood circulation Blood Circulation - drug effects Confidence intervals Danio rerio Developmental alterations Developmental stages Edema Edema - chemically induced Embryo, Nonmammalian - abnormalities Embryo, Nonmammalian - drug effects Embryos Exposure Female Fertilization Fins Hemostasis - drug effects Larva - drug effects Larvae Lethal Dose 50 Lower bounds Male Notochord Notochord - abnormalities Notochord - drug effects Parabens Parabens - toxicity Pericardium - drug effects Pericardium - pathology Spinal cord Sublethal effects Toxicity Toxicology Upper bounds Water Pollutants, Chemical - toxicity Yolk Yolk sac Yolk Sac - abnormalities Yolk Sac - drug effects Zebrafish Zebrafish - abnormalities Zebrafish larvae
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