In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations

•Ibuprofen-loaded poly(3,4-ethylenedioxypyrrole) is assessed as a neural interface.•Electrochemically superior material is formed via a three-step immobilization method.•PEDOP is able to immobilize up to 250 µg/ml of IBU and elute it within circa 20 days.•IBU-loaded PEDOP controls astrocyte activati...

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Veröffentlicht in:	Bioelectrochemistry (Amsterdam, Netherlands) Netherlands), 2020-08, Vol.134, p.107528, Article 107528
Hauptverfasser:	Krukiewicz, Katarzyna, Kowalik, Agnieszka, Turczyn, Roman, Biggs, Manus J.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Anti-inflammatory agents Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Astrocytes - drug effects Astrocytes - pathology Attenuation Capacitance Computer applications Conducting polymers Drug Compounding Drug delivery Drug Liberation Epilepsy Fabrication Ibuprofen Ibuprofen - chemistry Ibuprofen - pharmacology Immobilization Implants Inflammation Movement disorders Neural interfaces Neurodegenerative diseases Neuroinflammation Neurological diseases Neuroprotection Nonsteroidal anti-inflammatory drugs Parkinson's disease Poly(3,4-ethylenedioxypyrrole) Pyrroles - chemistry Recovery of function Storage capacity
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