Chronic exposure of bisphenol A impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways

[Display omitted] •Bisphenol-A, a widespread endocrine-disrupting chemical, has been recognized as a risk factor for metabolic disorders.•Bisphenol A impairs carbohydrate metabolism via downregulation of carbohydrate metabolizing enzymes.•Bisphenol A impairs lipid metabolism via downregulations of l...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2020-08, Vol.78, p.103387, Article 103387
Hauptverfasser:	Haq, Muhammad Ejaz ul, Akash, Muhammad Sajid Hamid, Rehman, Kanwal, Mahmood, Malik Hassan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA carboxylase AKT protein Animals Benzhydryl Compounds - toxicity Biomarkers Bisphenol A Blood Glucose - drug effects BPA exposure Carbohydrate metabolism Carbohydrate Metabolism - drug effects Carbohydrates Chronic exposure Dimethyl sulfoxide Endocrine disruptors Endocrine Disruptors - toxicity Exposure Gene expression Glucose Glucose Transporter Type 2 - metabolism Glucose Transporter Type 4 - metabolism Glucose-6-phosphatase Glucosidase Hexokinase Inflammation Insulin Insulin - blood Insulin resistance Interleukin 6 Leptin Lipid metabolism Lipid Metabolism - drug effects Lipid peroxidation Lipids Metabolic disorder Metabolic disorders Metabolic Networks and Pathways - drug effects Metabolic pathways Metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Oxidation resistance Oxidative stress Oxidative Stress - drug effects Pancreas - drug effects Pancreas - metabolism Pancreas - pathology Phenols - toxicity Pro-inflammatory cytokines Rats, Wistar Reductases Risk analysis Risk factors Serum levels Squalene Tumor necrosis factor-α α-Amylase α-Glucosidase
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