Efficacy of recombinant Marek’s disease virus vectored vaccines with computationally optimized broadly reactive antigen (COBRA) hemagglutinin insert against genetically diverse H5 high pathogenicity avian influenza viruses

•vHVT-H5 vaccines were tested for protection against HPAI viruses in chickens.•All vaccines provided clinical protection and reduced viral shedding.•COBRA vHVT-H5 vaccines elicited broadest antibody responses against diverse strains.•Wild-type vHVT-H5 vaccines elicited responses only against close g...

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Veröffentlicht in:	Vaccine 2021-04, Vol.39 (14), p.1933-1942
Hauptverfasser:	Bertran, Kateri, Kassa, Aemro, Criado, Miria F., Nuñez, Ivette A., Lee, Dong-Hun, Killmaster, Lindsay, Sá e Silva, Mariana, Ross, Ted M., Mebatsion, Teshome, Pritchard, Nikki, Swayne, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigenic drift antigenic variation Antigens Aquatic birds Avian flu Avian influenza Birds China COBRA cross reaction Cytomegalovirus Drift Genetic engineering Hemagglutinins Homology HPAIV HVT recombinant vector vaccine Influenza Influenza A Inserts Marek's disease Pathogenicity Pathogens Phylogeny Poultry Reduction Strains (organisms) Vaccines Viruses
Online-Zugang:	Volltext
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