Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

APOBEC3A (A3A) and APOBEC3B (A3B) enzymes drive APOBEC-mediated mutagenesis. Identification of factors affecting the activity of these enzymes could help modulate mutagenesis and associated clinical outcomes. Here, we show that canonical and alternatively spliced A3A and A3B isoforms produce corresp...

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Veröffentlicht in:	Communications biology 2021-03, Vol.4 (1), p.386-16, Article 386
Hauptverfasser:	Rouf Banday, A., Onabajo, Olusegun O., Lin, Seraph Han-Yin, Obajemu, Adeola, Vargas, Joselin M., Delviks-Frankenberry, Krista A., Lamy, Philippe, Bayanjargal, Ariunaa, Zettelmeyer, Clara, Florez-Vargas, Oscar, Pathak, Vinay K., Dyrskjøt, Lars, Prokunina-Olsson, Ludmila
Format:	Artikel
Sprache:	eng
Schlagworte:	38/109 38/22 38/23 38/39 38/44 38/70 38/77 38/89 38/91 45/29 631/208/1792 631/208/191/2018 692/699/67/589/1336 Alternative Splicing Biology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Bladder cancer Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Enzymes Epoxy Compounds - pharmacology Exons Gene Expression Regulation, Neoplastic HEK293 Cells HeLa Cells Hep G2 Cells Humans Isoenzymes Isoforms Life Sciences Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Macrolides - pharmacology Minor Histocompatibility Antigens - genetics Minor Histocompatibility Antigens - metabolism Multidisciplinary Sciences Mutagenesis Oligonucleotides Phosphoproteins - antagonists & inhibitors Phosphoproteins - metabolism Progression-Free Survival Proteins - genetics Proteins - metabolism RNA Splicing Factors - antagonists & inhibitors RNA Splicing Factors - metabolism Science & Technology Science & Technology - Other Topics Urinary Bladder Neoplasms - enzymology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - therapy
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