New dihydrochromene and xanthone derivatives from Lisotrigona furva propolis
A new dihydrochromene derivative, named lisofurvin (1) and a xanthone, named dihydrobrasixanthone B (2) together with twenty one known compounds (3−23) were isolated from propolis of the stingless bee Lisotrigona furva. Their chemical structures were determined by means of spectroscopic methods incl...
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| Veröffentlicht in: | Fitoterapia 2021-03, Vol.149, p.104821, Article 104821 |
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| creator | Oanh, Vu Thi Kim Thoa, Ha Thi Hang, Nguyen Thi Minh Phuong, Diep Thi Lan Lien, Nguyen Thi Phuong Popova, Milena Trusheva, Boryana Bankova, Vassya Le, Thanh Nguyen |
| description | A new dihydrochromene derivative, named lisofurvin (1) and a xanthone, named dihydrobrasixanthone B (2) together with twenty one known compounds (3−23) were isolated from propolis of the stingless bee Lisotrigona furva. Their chemical structures were determined by means of spectroscopic methods including 1D and 2D NMR, and MS. The chemical constituents are predominantly geranyl(oxy) xanthones and Cratoxylum cochinchinense was suggested as a resin source, besides two other plants Mangifera indica and dammar trees (Dipterocarpaceae). Compound 1 showed significant cytotoxic activity against KB, HepG-2, and Lu-1 cancer cell lines with IC50 values range from 12.63 to 15.17 μg/mL. Several isolated compounds were active against one to four tested cancer cell lines. In addition, among the isolated compounds, α-mangostin (15) displayed the strongest antimicrobial activity against three Gram (+) strains, P. aeruginosa, and C. albicans with MIC values ranging between 1 and 2 μg/mL. Compound 22 showed good activity against three Gram (+) strains and C. albicans.
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| doi_str_mv | 10.1016/j.fitote.2020.104821 |
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[Display omitted]</description><subject>Animals</subject><subject>Anti-Infective Agents - isolation & purification</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial</subject><subject>Antimicrobial activity</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Bees</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Clusiaceae - chemistry</subject><subject>Cratoxylum cochinchinense</subject><subject>Cytotoxicity</subject><subject>Dipterocarpaceae - chemistry</subject><subject>Humans</subject><subject>Lisotrigona furva</subject><subject>Mangifera - chemistry</subject><subject>Molecular Structure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phytochemicals - isolation & purification</subject><subject>Phytochemicals - pharmacology</subject><subject>Propolis</subject><subject>Propolis - chemistry</subject><subject>Tumor cell lines</subject><subject>Vietnam</subject><subject>Xanthones</subject><subject>Xanthones - isolation & purification</subject><subject>Xanthones - pharmacology</subject><issn>0367-326X</issn><issn>1873-6971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6D0QKnrsmTdqmF0HELyh6UfAWssnETdlt1iSt7r-3S1ePnoYZnpmXeRA6J3hOMCmumrmx0UWYZzjbjRjPyAGaEl7StKhKcoimmBZlSrPifYJOQmgwJjll5BhNKKW8LBidovoZvhJtl1vtnVp6t4YWEtnq5Fu2cemGRoO3vYy2h5CYAUhqG1z09sO1MjGd72Wy8W7jVjacoiMjVwHO9nWG3u7vXm8f0_rl4en2pk4VrXBMpS5LQzXPMeeayZIUmeGaMKWh0oxpYogCUAxXqlhgxbnhinCVSVlhVmJJZ-hyvDsEf3YQomhc59shUmQ5pqzIcF4NFBsp5V0IHozYeLuWfisIFjuFohGjQrFTKEaFw9rF_ni3WIP-W_p1NgDXIwDDi70FL4Ky0CrQ1oOKQjv7f8IP-1SFOQ</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Oanh, Vu Thi Kim</creator><creator>Thoa, Ha Thi</creator><creator>Hang, Nguyen Thi Minh</creator><creator>Phuong, Diep Thi Lan</creator><creator>Lien, Nguyen Thi Phuong</creator><creator>Popova, Milena</creator><creator>Trusheva, Boryana</creator><creator>Bankova, Vassya</creator><creator>Le, Thanh Nguyen</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>202103</creationdate><title>New dihydrochromene and xanthone derivatives from Lisotrigona furva propolis</title><author>Oanh, Vu Thi Kim ; 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Their chemical structures were determined by means of spectroscopic methods including 1D and 2D NMR, and MS. The chemical constituents are predominantly geranyl(oxy) xanthones and Cratoxylum cochinchinense was suggested as a resin source, besides two other plants Mangifera indica and dammar trees (Dipterocarpaceae). Compound 1 showed significant cytotoxic activity against KB, HepG-2, and Lu-1 cancer cell lines with IC50 values range from 12.63 to 15.17 μg/mL. Several isolated compounds were active against one to four tested cancer cell lines. In addition, among the isolated compounds, α-mangostin (15) displayed the strongest antimicrobial activity against three Gram (+) strains, P. aeruginosa, and C. albicans with MIC values ranging between 1 and 2 μg/mL. Compound 22 showed good activity against three Gram (+) strains and C. albicans.
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| subjects | Animals Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial Antimicrobial activity Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Bees Biotechnology Cancer Cell Line, Tumor Clusiaceae - chemistry Cratoxylum cochinchinense Cytotoxicity Dipterocarpaceae - chemistry Humans Lisotrigona furva Mangifera - chemistry Molecular Structure NMR Nuclear magnetic resonance Phytochemicals - isolation & purification Phytochemicals - pharmacology Propolis Propolis - chemistry Tumor cell lines Vietnam Xanthones Xanthones - isolation & purification Xanthones - pharmacology |
| title | New dihydrochromene and xanthone derivatives from Lisotrigona furva propolis |
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