0048 CEREBRAL SEROTONIN EXPRESSION PREDICTS DAYTIME SLEEP AND SLEEP DEVELOPMENT IN INFANT RHESUS MONKEYS
Abstract Introduction: Cerebral serotonin expression and sleep share a complex and as yet unclear association in early development. Though serotonin is linked with sleep-wake patterns in early childhood, whether this association emerges during infancy remains to be discovered. We hypothesized that t...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2017-04, Vol.40 (suppl_1), p.A18-A19 |
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| creator | Baxter, A Wood, E Kay, DB Higley, JD Suomi, SJ |
| description | Abstract
Introduction:
Cerebral serotonin expression and sleep share a complex and as yet unclear association in early development. Though serotonin is linked with sleep-wake patterns in early childhood, whether this association emerges during infancy remains to be discovered. We hypothesized that the developing serotonergic system will be associated with the development of sleep-wake patterns.
Methods:
We investigated the associations between cerebral serotonin expression and sleep development during the first month of life in 152 nursery-reared infant rhesus macaques (Macaca mulatta). Cerebral serotonin expression was determined using cerebrospinal fluid serotonin metabolite 5-hydroxyindoleacetic acid (CSF 5-HIAA) concentrations, relative to weight, sampled at 2 and 4 weeks post-birth. Sleep-wake states were rated by trained observers every two hours from 0800-2000 hours. Sleep-wake states were scored as awake=1, drowsy=2, or asleep=3. For analyses, daytime sleep-wake states were averaged across the 7 days prior to each CSF sampling. Paired-samples t-test, Wilcoxon signed ranks test, and Spearman’s ρ were utilized to explore associations between time points, averages, and change scores (week 4 minus week 2) for both CSF 5-HIAA and sleep-wake states.
Results:
Daytime sleep (t(239)=17.27, p |
| doi_str_mv | 10.1093/sleepj/zsx050.047 |
| format | Article |
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Introduction:
Cerebral serotonin expression and sleep share a complex and as yet unclear association in early development. Though serotonin is linked with sleep-wake patterns in early childhood, whether this association emerges during infancy remains to be discovered. We hypothesized that the developing serotonergic system will be associated with the development of sleep-wake patterns.
Methods:
We investigated the associations between cerebral serotonin expression and sleep development during the first month of life in 152 nursery-reared infant rhesus macaques (Macaca mulatta). Cerebral serotonin expression was determined using cerebrospinal fluid serotonin metabolite 5-hydroxyindoleacetic acid (CSF 5-HIAA) concentrations, relative to weight, sampled at 2 and 4 weeks post-birth. Sleep-wake states were rated by trained observers every two hours from 0800-2000 hours. Sleep-wake states were scored as awake=1, drowsy=2, or asleep=3. For analyses, daytime sleep-wake states were averaged across the 7 days prior to each CSF sampling. Paired-samples t-test, Wilcoxon signed ranks test, and Spearman’s ρ were utilized to explore associations between time points, averages, and change scores (week 4 minus week 2) for both CSF 5-HIAA and sleep-wake states.
Results:
Daytime sleep (t(239)=17.27, p<.001) and CSF 5-HIAA (Z = -9.9, p<.001) decreased significantly from week 2 to week 4. Higher CSF 5-HIAA was associated with more daytime sleep during the first month of development (ρ=.25, p=.003). Lower week 2 CSF 5-HIAA predicted greater reductions in sleep from week 2-week 4 (ρ=.16, p=.05). Greater reductions in CSF 5-HIAA from week 2 to week 4 predicted lower sleep at week 4 (ρ=-.18, p =.03).
Conclusion:
These important findings are among the first to demonstrate that, from birth, daytime sleep-wake patterns are predicted by cerebral serotonin expression. Considering the link between serotonin, sleep, and mood disorders later in life, these results have exciting implications for improving sleep with serotonin interventions.
Support (If Any):
This research was supported by the Laboratory of Comparative Ethology at the National Institute of Child Health & Human Development, National Institute of Health.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleepj/zsx050.047</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Serotonin ; Sleep</subject><ispartof>Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A18-A19</ispartof><rights>Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2017</rights><rights>Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Baxter, A</creatorcontrib><creatorcontrib>Wood, E</creatorcontrib><creatorcontrib>Kay, DB</creatorcontrib><creatorcontrib>Higley, JD</creatorcontrib><creatorcontrib>Suomi, SJ</creatorcontrib><title>0048 CEREBRAL SEROTONIN EXPRESSION PREDICTS DAYTIME SLEEP AND SLEEP DEVELOPMENT IN INFANT RHESUS MONKEYS</title><title>Sleep (New York, N.Y.)</title><description>Abstract
Introduction:
Cerebral serotonin expression and sleep share a complex and as yet unclear association in early development. Though serotonin is linked with sleep-wake patterns in early childhood, whether this association emerges during infancy remains to be discovered. We hypothesized that the developing serotonergic system will be associated with the development of sleep-wake patterns.
Methods:
We investigated the associations between cerebral serotonin expression and sleep development during the first month of life in 152 nursery-reared infant rhesus macaques (Macaca mulatta). Cerebral serotonin expression was determined using cerebrospinal fluid serotonin metabolite 5-hydroxyindoleacetic acid (CSF 5-HIAA) concentrations, relative to weight, sampled at 2 and 4 weeks post-birth. Sleep-wake states were rated by trained observers every two hours from 0800-2000 hours. Sleep-wake states were scored as awake=1, drowsy=2, or asleep=3. For analyses, daytime sleep-wake states were averaged across the 7 days prior to each CSF sampling. Paired-samples t-test, Wilcoxon signed ranks test, and Spearman’s ρ were utilized to explore associations between time points, averages, and change scores (week 4 minus week 2) for both CSF 5-HIAA and sleep-wake states.
Results:
Daytime sleep (t(239)=17.27, p<.001) and CSF 5-HIAA (Z = -9.9, p<.001) decreased significantly from week 2 to week 4. Higher CSF 5-HIAA was associated with more daytime sleep during the first month of development (ρ=.25, p=.003). Lower week 2 CSF 5-HIAA predicted greater reductions in sleep from week 2-week 4 (ρ=.16, p=.05). Greater reductions in CSF 5-HIAA from week 2 to week 4 predicted lower sleep at week 4 (ρ=-.18, p =.03).
Conclusion:
These important findings are among the first to demonstrate that, from birth, daytime sleep-wake patterns are predicted by cerebral serotonin expression. Considering the link between serotonin, sleep, and mood disorders later in life, these results have exciting implications for improving sleep with serotonin interventions.
Support (If Any):
This research was supported by the Laboratory of Comparative Ethology at the National Institute of Child Health & Human Development, National Institute of Health.</description><subject>Serotonin</subject><subject>Sleep</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkFFPgzAUhRujiXP6A3xr4qtst4N28IjQOSKDhaJxT6SUEl2mQ-oS9ddbw36AT_fc3HPuST6ErglMCATu1Oy07rbTH_MFFCbgzU_QiFAKTmDPp2gEhBHHJ0DP0YUxW7C7F7gj9ALg-TjiBb8rwhQLXuRlniUZ5s_rgguR5Bm2Ik6iUuA43JTJimORcr7GYRYfVcyfeJqvVzwrsY0m2SK0qlhy8SjwKs8e-EZcorNW7oy-Os4xKhe8jJZOmt8nUZg6ilCYO0zSVlGl3VoGLiVEMdnWSgfKZz71m4bKeSM10bKGhnm1JMonqvGBBa7HZoE7RjfD267ffxy0-ay2-0P_bhurGQXX8wihzLrI4FL93phet1XXv77J_rsiUP3xrAae1cCzsjxt5nbI7A_dP-y_R91x2A</recordid><startdate>20170428</startdate><enddate>20170428</enddate><creator>Baxter, A</creator><creator>Wood, E</creator><creator>Kay, DB</creator><creator>Higley, JD</creator><creator>Suomi, SJ</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20170428</creationdate><title>0048 CEREBRAL SEROTONIN EXPRESSION PREDICTS DAYTIME SLEEP AND SLEEP DEVELOPMENT IN INFANT RHESUS MONKEYS</title><author>Baxter, A ; Wood, E ; Kay, DB ; Higley, JD ; Suomi, SJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1507-6a5fc5ce3ba93511c6afbce9c86858dd5a7dae1eab0d64ba1c81cd8069346293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Serotonin</topic><topic>Sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baxter, A</creatorcontrib><creatorcontrib>Wood, E</creatorcontrib><creatorcontrib>Kay, DB</creatorcontrib><creatorcontrib>Higley, JD</creatorcontrib><creatorcontrib>Suomi, SJ</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baxter, A</au><au>Wood, E</au><au>Kay, DB</au><au>Higley, JD</au><au>Suomi, SJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>0048 CEREBRAL SEROTONIN EXPRESSION PREDICTS DAYTIME SLEEP AND SLEEP DEVELOPMENT IN INFANT RHESUS MONKEYS</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2017-04-28</date><risdate>2017</risdate><volume>40</volume><issue>suppl_1</issue><spage>A18</spage><epage>A19</epage><pages>A18-A19</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Introduction:
Cerebral serotonin expression and sleep share a complex and as yet unclear association in early development. Though serotonin is linked with sleep-wake patterns in early childhood, whether this association emerges during infancy remains to be discovered. We hypothesized that the developing serotonergic system will be associated with the development of sleep-wake patterns.
Methods:
We investigated the associations between cerebral serotonin expression and sleep development during the first month of life in 152 nursery-reared infant rhesus macaques (Macaca mulatta). Cerebral serotonin expression was determined using cerebrospinal fluid serotonin metabolite 5-hydroxyindoleacetic acid (CSF 5-HIAA) concentrations, relative to weight, sampled at 2 and 4 weeks post-birth. Sleep-wake states were rated by trained observers every two hours from 0800-2000 hours. Sleep-wake states were scored as awake=1, drowsy=2, or asleep=3. For analyses, daytime sleep-wake states were averaged across the 7 days prior to each CSF sampling. Paired-samples t-test, Wilcoxon signed ranks test, and Spearman’s ρ were utilized to explore associations between time points, averages, and change scores (week 4 minus week 2) for both CSF 5-HIAA and sleep-wake states.
Results:
Daytime sleep (t(239)=17.27, p<.001) and CSF 5-HIAA (Z = -9.9, p<.001) decreased significantly from week 2 to week 4. Higher CSF 5-HIAA was associated with more daytime sleep during the first month of development (ρ=.25, p=.003). Lower week 2 CSF 5-HIAA predicted greater reductions in sleep from week 2-week 4 (ρ=.16, p=.05). Greater reductions in CSF 5-HIAA from week 2 to week 4 predicted lower sleep at week 4 (ρ=-.18, p =.03).
Conclusion:
These important findings are among the first to demonstrate that, from birth, daytime sleep-wake patterns are predicted by cerebral serotonin expression. Considering the link between serotonin, sleep, and mood disorders later in life, these results have exciting implications for improving sleep with serotonin interventions.
Support (If Any):
This research was supported by the Laboratory of Comparative Ethology at the National Institute of Child Health & Human Development, National Institute of Health.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/sleepj/zsx050.047</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Serotonin Sleep |
| title | 0048 CEREBRAL SEROTONIN EXPRESSION PREDICTS DAYTIME SLEEP AND SLEEP DEVELOPMENT IN INFANT RHESUS MONKEYS |
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