0080 DIURNAL VARIATION OF PLASMA LYSOPHOSPHATIDYL LIPIDS IN HEALTHY NON-OBESE OLDER ADULTS

0080 DIURNAL VARIATION OF PLASMA LYSOPHOSPHATIDYL LIPIDS IN HEALTHY NON-OBESE OLDER ADULTS

Abstract Introduction: Disruption of daily rhythms in energy expenditure has been implicated in metabolic dysfunction. The rhythmic control of lipid metabolism and its temporal coordination with rest-activity and food intake have been studied in young adults, but remain poorly understood in older ad...

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Veröffentlicht in:Sleep (New York, N.Y.) N.Y.), 2017-04, Vol.40 (suppl_1), p.A30-A31
Hauptverfasser: Zitting, K, Gathungu, RM, Sniatynski, MJ, Marur, VR, Vujovic, N, Wang, W, Czeisler, CA, Kristal, BS, Duffy, JF
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Lipids
Metabolism
Older people
Sleep
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container_issue suppl_1
container_start_page A30
container_title Sleep (New York, N.Y.)
container_volume 40
creator Zitting, K
Gathungu, RM
Sniatynski, MJ
Marur, VR
Vujovic, N
Wang, W
Czeisler, CA
Kristal, BS
Duffy, JF
description Abstract Introduction: Disruption of daily rhythms in energy expenditure has been implicated in metabolic dysfunction. The rhythmic control of lipid metabolism and its temporal coordination with rest-activity and food intake have been studied in young adults, but remain poorly understood in older adults who are at greater risk for metabolic disorders. Lysophosphatidyl lipids (LPLs) are a class of membrane phosphatidyl lipids reported to exhibit diurnal variation. We characterized the effects of rest-activity and timing of food intake on LPLs in healthy older adults studied in controlled laboratory conditions. Methods: As part of a larger study, blood samples from eight healthy non-obese older adults (56–69, 4 women) were collected every 4h for 24h. Participants had a 10h scheduled sleep episode followed by 14 h of wakefulness with controlled posture and activity, during which time three calorie/nutrient controlled meals (breakfast, lunch, dinner) were served. Plasma lipid profiling was done by liquid chromatography-high resolution mass spectrometry. Eighteen LPLs were identified based on their m/z in both positive and negative ionization modes. Rhythmicity was tested by fitting a cosinor model; two-way ANOVA was used to test the effects of rest-activity and fasting (>8h since last meal) on LPL levels. Results: All 18 LPLs showed rhythmicity (p
doi_str_mv 10.1093/sleepj/zsx050.079
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The rhythmic control of lipid metabolism and its temporal coordination with rest-activity and food intake have been studied in young adults, but remain poorly understood in older adults who are at greater risk for metabolic disorders. Lysophosphatidyl lipids (LPLs) are a class of membrane phosphatidyl lipids reported to exhibit diurnal variation. We characterized the effects of rest-activity and timing of food intake on LPLs in healthy older adults studied in controlled laboratory conditions. Methods: As part of a larger study, blood samples from eight healthy non-obese older adults (56–69, 4 women) were collected every 4h for 24h. Participants had a 10h scheduled sleep episode followed by 14 h of wakefulness with controlled posture and activity, during which time three calorie/nutrient controlled meals (breakfast, lunch, dinner) were served. Plasma lipid profiling was done by liquid chromatography-high resolution mass spectrometry. Eighteen LPLs were identified based on their m/z in both positive and negative ionization modes. Rhythmicity was tested by fitting a cosinor model; two-way ANOVA was used to test the effects of rest-activity and fasting (&gt;8h since last meal) on LPL levels. Results: All 18 LPLs showed rhythmicity (p&lt;0.001). 16 were significantly different between scheduled sleep and wake (p&lt;0.05), with higher levels during sleep. 10 of those (and 2 others) were also significantly different between fasted and non-fasted conditions (p&lt;0.05), with higher levels during the non-fasting condition. LPL levels were highest around bedtime (~2.5h after dinner) and lowest before breakfast after the overnight fast. Conclusion: Plasma LPL levels vary with both the rest-activity cycle and fasting-feeding in healthy non-obese older adults. Future studies that assess whether these and other LPLs are also under circadian control will allow us to understand how circadian dysregulation can lead to metabolic syndrome. Support (If Any): Supported by P01AG009975. Studies carried out in the Brigham and Women’s Hospital Center for Clinical Investigation, part of Harvard Clinical and Translational Science Center supported by UL1TR001102. KMZ supported by a fellowship from the Finnish Cultural Foundation. NV supported by T32HL007901and F32AG051325-01A1.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleepj/zsx050.079</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Lipids ; Metabolism ; Older people ; Sleep</subject><ispartof>Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A30-A31</ispartof><rights>Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2017</rights><rights>Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Zitting, K</creatorcontrib><creatorcontrib>Gathungu, RM</creatorcontrib><creatorcontrib>Sniatynski, MJ</creatorcontrib><creatorcontrib>Marur, VR</creatorcontrib><creatorcontrib>Vujovic, N</creatorcontrib><creatorcontrib>Wang, W</creatorcontrib><creatorcontrib>Czeisler, CA</creatorcontrib><creatorcontrib>Kristal, BS</creatorcontrib><creatorcontrib>Duffy, JF</creatorcontrib><title>0080 DIURNAL VARIATION OF PLASMA LYSOPHOSPHATIDYL LIPIDS IN HEALTHY NON-OBESE OLDER ADULTS</title><title>Sleep (New York, N.Y.)</title><description>Abstract Introduction: Disruption of daily rhythms in energy expenditure has been implicated in metabolic dysfunction. The rhythmic control of lipid metabolism and its temporal coordination with rest-activity and food intake have been studied in young adults, but remain poorly understood in older adults who are at greater risk for metabolic disorders. Lysophosphatidyl lipids (LPLs) are a class of membrane phosphatidyl lipids reported to exhibit diurnal variation. We characterized the effects of rest-activity and timing of food intake on LPLs in healthy older adults studied in controlled laboratory conditions. Methods: As part of a larger study, blood samples from eight healthy non-obese older adults (56–69, 4 women) were collected every 4h for 24h. Participants had a 10h scheduled sleep episode followed by 14 h of wakefulness with controlled posture and activity, during which time three calorie/nutrient controlled meals (breakfast, lunch, dinner) were served. Plasma lipid profiling was done by liquid chromatography-high resolution mass spectrometry. Eighteen LPLs were identified based on their m/z in both positive and negative ionization modes. Rhythmicity was tested by fitting a cosinor model; two-way ANOVA was used to test the effects of rest-activity and fasting (&gt;8h since last meal) on LPL levels. Results: All 18 LPLs showed rhythmicity (p&lt;0.001). 16 were significantly different between scheduled sleep and wake (p&lt;0.05), with higher levels during sleep. 10 of those (and 2 others) were also significantly different between fasted and non-fasted conditions (p&lt;0.05), with higher levels during the non-fasting condition. LPL levels were highest around bedtime (~2.5h after dinner) and lowest before breakfast after the overnight fast. Conclusion: Plasma LPL levels vary with both the rest-activity cycle and fasting-feeding in healthy non-obese older adults. Future studies that assess whether these and other LPLs are also under circadian control will allow us to understand how circadian dysregulation can lead to metabolic syndrome. Support (If Any): Supported by P01AG009975. Studies carried out in the Brigham and Women’s Hospital Center for Clinical Investigation, part of Harvard Clinical and Translational Science Center supported by UL1TR001102. KMZ supported by a fellowship from the Finnish Cultural Foundation. 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The rhythmic control of lipid metabolism and its temporal coordination with rest-activity and food intake have been studied in young adults, but remain poorly understood in older adults who are at greater risk for metabolic disorders. Lysophosphatidyl lipids (LPLs) are a class of membrane phosphatidyl lipids reported to exhibit diurnal variation. We characterized the effects of rest-activity and timing of food intake on LPLs in healthy older adults studied in controlled laboratory conditions. Methods: As part of a larger study, blood samples from eight healthy non-obese older adults (56–69, 4 women) were collected every 4h for 24h. Participants had a 10h scheduled sleep episode followed by 14 h of wakefulness with controlled posture and activity, during which time three calorie/nutrient controlled meals (breakfast, lunch, dinner) were served. Plasma lipid profiling was done by liquid chromatography-high resolution mass spectrometry. Eighteen LPLs were identified based on their m/z in both positive and negative ionization modes. Rhythmicity was tested by fitting a cosinor model; two-way ANOVA was used to test the effects of rest-activity and fasting (&gt;8h since last meal) on LPL levels. Results: All 18 LPLs showed rhythmicity (p&lt;0.001). 16 were significantly different between scheduled sleep and wake (p&lt;0.05), with higher levels during sleep. 10 of those (and 2 others) were also significantly different between fasted and non-fasted conditions (p&lt;0.05), with higher levels during the non-fasting condition. LPL levels were highest around bedtime (~2.5h after dinner) and lowest before breakfast after the overnight fast. Conclusion: Plasma LPL levels vary with both the rest-activity cycle and fasting-feeding in healthy non-obese older adults. Future studies that assess whether these and other LPLs are also under circadian control will allow us to understand how circadian dysregulation can lead to metabolic syndrome. Support (If Any): Supported by P01AG009975. Studies carried out in the Brigham and Women’s Hospital Center for Clinical Investigation, part of Harvard Clinical and Translational Science Center supported by UL1TR001102. KMZ supported by a fellowship from the Finnish Cultural Foundation. NV supported by T32HL007901and F32AG051325-01A1.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/sleepj/zsx050.079</doi><oa>free_for_read</oa></addata></record>
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source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Lipids
Metabolism
Older people
Sleep
title 0080 DIURNAL VARIATION OF PLASMA LYSOPHOSPHATIDYL LIPIDS IN HEALTHY NON-OBESE OLDER ADULTS
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