Chronic Treatment With Hydrogen Sulfide Donor GYY4137 Mitigates Microglial and Astrocyte Activation in the Spinal Cord of Streptozotocin-Induced Diabetic Rats

Abstract Long-term diabetic patients suffer immensely from diabetic neuropathy. This study was designed to investigate the effects of hydrogen sulfide (H2S) on peripheral neuropathy, activation of microglia, astrocytes, and the cascade secretion of proinflammatory cytokines in the streptozotocin (ST...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2020-12, Vol.79 (12), p.1320-1343
Hauptverfasser:	Shayea, Abdulaziz M F, Mousa, Alyaa M A, Renno, Waleed M, Nadar, Mohammed Shaban, Qabazard, Bedoor, Yousif, Mariam H M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - metabolism Cytokines Cytokines - metabolism Diabetes Diabetes Mellitus, Experimental - metabolism Diabetic Neuropathies - drug therapy Diabetic Neuropathies - metabolism Diabetic neuropathy Hyperalgesia Hyperalgesia - drug therapy Hyperalgesia - metabolism Inflammation Mediators - metabolism Male Microglia - drug effects Microglia - metabolism Morpholines - pharmacology Morpholines - therapeutic use Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Organothiophosphorus Compounds - pharmacology Organothiophosphorus Compounds - therapeutic use Rats Rats, Sprague-Dawley Rodents Spinal cord Spinal Cord - drug effects Spinal Cord - metabolism Treatment Outcome
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Zusammenfassung:	Abstract Long-term diabetic patients suffer immensely from diabetic neuropathy. This study was designed to investigate the effects of hydrogen sulfide (H2S) on peripheral neuropathy, activation of microglia, astrocytes, and the cascade secretion of proinflammatory cytokines in the streptozotocin (STZ)-induced peripheral diabetic neuropathy rat model. STZ-induced diabetic rats were treated with the water-soluble, slow-releasing H2S donor GYY4137 (50 mg/kg; i.p.) daily for 4 weeks. Antiallodynic/antihyperalgesic activities were evaluated using different tests and histopathological changes and the expression of proinflammatory cytokines in the spinal cord were examined. GYY4137 treatment produced neuroprotective effects in the spinal cord of diabetic animals and modulated their sensory deficits. The treatment decreased allodynia (p
ISSN:	0022-3069 1554-6578
DOI:	10.1093/jnen/nlaa127