Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of proinflammatory mediators in LPS stimulated RAW 264.7 macrophages

Methods: This study focuses on the mode of action of ALK-F (alkaloid fraction) isolated from Adhatoda vasica in attenuating the nitric oxide production which was estimated by Griess assay, tumor necrosis factor-a (TNF-a), and interleukin-6 (IL-6) expression was analyzed by ELISA and expression of CO...

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Veröffentlicht in:	Bioimpacts 2021-01, Vol.11 (1), p.15-22
Hauptverfasser:	Amala, Reddy, Sujatha, Sundaresan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alkaloids Ammonium Antioxidants Arachidonic acid Arginine Autocrine signalling Chloroform Chromatography Chronic illnesses Cyclooxygenase-1 Cyclooxygenase-2 Cytokines Diabetes Endothelial cells Enzyme-linked immunosorbent assay Fetal calf serum Fibroblasts Flavonoids Foot diseases High-performance liquid chromatography Inflammation Inflammatory diseases Interleukin 6 Leg ulcers Lipopolysaccharides Macrophages Medicinal plants NG-Nitroarginine methyl ester Nitric oxide Plants Polymerase chain reaction Side effects Steroid hormones Tumor necrosis factor-TNF Western blotting
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