Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy

The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in order to break the immunological tolerance. To this aim, heteroclitic peptides were designed introducing specific substitutions in the residue at position 4 (p4) binding to TCR. The effec...

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Veröffentlicht in:	Journal of translational medicine 2021-02, Vol.19 (1), p.89-89, Article 89
Hauptverfasser:	Cavalluzzo, Beatrice, Ragone, Concetta, Mauriello, Angela, Petrizzo, Annacarmen, Manolio, Carmen, Caporale, Andrea, Vitagliano, Luigi, Ruvo, Menotti, Buonaguro, Luigi, Tagliamonte, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino acids Animals Antigen (tumor-associated) Antigen receptors, T cell Antigenicity Antigens Antigens, Neoplasm Bioinformatics Cancer Chemical properties Design Health aspects Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens HLA-A2 Antigen Human papillomavirus Immunogenicity Immunological tolerance Major histocompatibility complex Medical research Medicine, Experimental Melanoma Mice Mutation Peptides Physiological aspects Protein Binding Receptors Receptors, Antigen, T-Cell T cell receptors T cells Tumor antigens Tumor cell lines
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