1112 Mental Health And Sleep Disorders Are Associated With Elevated C-reactive Protein In Returning Veterans
Abstract Introduction Mental health disorders and sleep disorders are associated with systemic inflammation, which may be a key element linking these highly co-occurring conditions to negative health outcomes. This study used national VA medical records to examine C-reactive protein (CRP) levels in...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2020-05, Vol.43 (Supplement_1), p.A423-A423 |
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| creator | Straus, L D Colvonen, P J Bertenthal, D Neylan, T C O’Donovan, A |
| description | Abstract
Introduction
Mental health disorders and sleep disorders are associated with systemic inflammation, which may be a key element linking these highly co-occurring conditions to negative health outcomes. This study used national VA medical records to examine C-reactive protein (CRP) levels in Iraq/Afghanistan veterans based on presence of mental health and/or sleep disorder diagnoses.
Methods
We examined medical records for 16,576 Iraq/Afghanistan veterans under age 55 who had high-sensitivity CRP results reported. ICD diagnostic codes were used to compare CRP values for: a) veterans without sleep disorders or mental health diagnoses, b) veterans with mental health disorders only, c) veterans with sleep disorders only, and d) veterans with both conditions. In generalized linear models controlling for demographics, we examined the impact of diagnostic category on continuous CRP value as well as the risk of elevated CRP (>3mg/L).
Results
Veterans with mental health disorders (coeff=.14, p |
| doi_str_mv | 10.1093/sleep/zsaa056.1107 |
| format | Article |
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Introduction
Mental health disorders and sleep disorders are associated with systemic inflammation, which may be a key element linking these highly co-occurring conditions to negative health outcomes. This study used national VA medical records to examine C-reactive protein (CRP) levels in Iraq/Afghanistan veterans based on presence of mental health and/or sleep disorder diagnoses.
Methods
We examined medical records for 16,576 Iraq/Afghanistan veterans under age 55 who had high-sensitivity CRP results reported. ICD diagnostic codes were used to compare CRP values for: a) veterans without sleep disorders or mental health diagnoses, b) veterans with mental health disorders only, c) veterans with sleep disorders only, and d) veterans with both conditions. In generalized linear models controlling for demographics, we examined the impact of diagnostic category on continuous CRP value as well as the risk of elevated CRP (>3mg/L).
Results
Veterans with mental health disorders (coeff=.14, p<.001) and comorbid sleep and mental health disorders (coeff=.21, p<.001) had higher continuous CRP values compared to veterans without either condition. Veterans with comorbid sleep and mental health disorders had higher continuous CRP values than veterans with sleep disorders alone (coeff=.22, p<.041); however, there were few patients in the current sample who were diagnosed with sleep disorders alone (n=401, 2.4%). Additionally, veterans with mental health disorders (ARR=1.12, p=.004) and comorbid sleep and mental health disorders (ARR=1.15, p=.001) were more likely to have CRP values >3mg/L compared to veterans without either condition.
Conclusion
Sleep disorders were highly likely to co-occur with mental health disorders in this sample of Iraq/Afghanistan veterans. Mental health disorders and comorbid mental health/sleep disorders were associated with elevated C-reactive protein, indicating these patients are at highest risk for negative health outcomes. Future studies should investigate directionality of relationships among sleep disruption, mental health symptoms, and inflammation.
Support
VA Advanced Fellowship Program in Mental Illness Research and Treatment</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsaa056.1107</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Comorbidity ; Generalized linear models ; Medical records ; Mental disorders ; Mental health care ; Proteins ; Sleep disorders ; Veterans</subject><ispartof>Sleep (New York, N.Y.), 2020-05, Vol.43 (Supplement_1), p.A423-A423</ispartof><rights>Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com. 2020</rights><rights>Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Straus, L D</creatorcontrib><creatorcontrib>Colvonen, P J</creatorcontrib><creatorcontrib>Bertenthal, D</creatorcontrib><creatorcontrib>Neylan, T C</creatorcontrib><creatorcontrib>O’Donovan, A</creatorcontrib><title>1112 Mental Health And Sleep Disorders Are Associated With Elevated C-reactive Protein In Returning Veterans</title><title>Sleep (New York, N.Y.)</title><description>Abstract
Introduction
Mental health disorders and sleep disorders are associated with systemic inflammation, which may be a key element linking these highly co-occurring conditions to negative health outcomes. This study used national VA medical records to examine C-reactive protein (CRP) levels in Iraq/Afghanistan veterans based on presence of mental health and/or sleep disorder diagnoses.
Methods
We examined medical records for 16,576 Iraq/Afghanistan veterans under age 55 who had high-sensitivity CRP results reported. ICD diagnostic codes were used to compare CRP values for: a) veterans without sleep disorders or mental health diagnoses, b) veterans with mental health disorders only, c) veterans with sleep disorders only, and d) veterans with both conditions. In generalized linear models controlling for demographics, we examined the impact of diagnostic category on continuous CRP value as well as the risk of elevated CRP (>3mg/L).
Results
Veterans with mental health disorders (coeff=.14, p<.001) and comorbid sleep and mental health disorders (coeff=.21, p<.001) had higher continuous CRP values compared to veterans without either condition. Veterans with comorbid sleep and mental health disorders had higher continuous CRP values than veterans with sleep disorders alone (coeff=.22, p<.041); however, there were few patients in the current sample who were diagnosed with sleep disorders alone (n=401, 2.4%). Additionally, veterans with mental health disorders (ARR=1.12, p=.004) and comorbid sleep and mental health disorders (ARR=1.15, p=.001) were more likely to have CRP values >3mg/L compared to veterans without either condition.
Conclusion
Sleep disorders were highly likely to co-occur with mental health disorders in this sample of Iraq/Afghanistan veterans. Mental health disorders and comorbid mental health/sleep disorders were associated with elevated C-reactive protein, indicating these patients are at highest risk for negative health outcomes. Future studies should investigate directionality of relationships among sleep disruption, mental health symptoms, and inflammation.
Support
VA Advanced Fellowship Program in Mental Illness Research and Treatment</description><subject>Comorbidity</subject><subject>Generalized linear models</subject><subject>Medical records</subject><subject>Mental disorders</subject><subject>Mental health care</subject><subject>Proteins</subject><subject>Sleep disorders</subject><subject>Veterans</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNUMtOwzAQtBBIlMIPcLLEOdRr10l8rEqhlYpAPI-WE28gVUiC7VaCr8d9fACn0WhnZneHkEtg18CUGPkGsR_9emOYTK8BWHZEBiAlS1ScH5MBgxSSHJg8JWfer1jkYyUGpAEATu-xDaahczRN-KST1tLnbSC9qX3nLDpPJw7pxPuurE1AS9_rqJs1uNmxaeLQlKHeIH10XcC6pYuWPmFYu7ZuP-gbBnSm9efkpDKNx4sDDsnr7exlOk-WD3eL6WSZlCBFlkDOU2CVBKPiO1IIxXiBEtBYsBWMCw4wLjObWaFMZmRa5DLlhZUCUowohuRqn9u77nuNPuhVF0-JKzWXjOcK8lRFFd-rStd577DSvau_jPvRwPS2Vb1rVR9a1dtWoynZm7p1_x_9H18Aeug</recordid><startdate>20200527</startdate><enddate>20200527</enddate><creator>Straus, L D</creator><creator>Colvonen, P J</creator><creator>Bertenthal, D</creator><creator>Neylan, T C</creator><creator>O’Donovan, A</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20200527</creationdate><title>1112 Mental Health And Sleep Disorders Are Associated With Elevated C-reactive Protein In Returning Veterans</title><author>Straus, L D ; Colvonen, P J ; Bertenthal, D ; Neylan, T C ; O’Donovan, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1537-182610f51a9a05533902be51ead1df14b2114c7d7d39a7a56b8562bd5316e2bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Comorbidity</topic><topic>Generalized linear models</topic><topic>Medical records</topic><topic>Mental disorders</topic><topic>Mental health care</topic><topic>Proteins</topic><topic>Sleep disorders</topic><topic>Veterans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Straus, L D</creatorcontrib><creatorcontrib>Colvonen, P J</creatorcontrib><creatorcontrib>Bertenthal, D</creatorcontrib><creatorcontrib>Neylan, T C</creatorcontrib><creatorcontrib>O’Donovan, A</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Straus, L D</au><au>Colvonen, P J</au><au>Bertenthal, D</au><au>Neylan, T C</au><au>O’Donovan, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1112 Mental Health And Sleep Disorders Are Associated With Elevated C-reactive Protein In Returning Veterans</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2020-05-27</date><risdate>2020</risdate><volume>43</volume><issue>Supplement_1</issue><spage>A423</spage><epage>A423</epage><pages>A423-A423</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Introduction
Mental health disorders and sleep disorders are associated with systemic inflammation, which may be a key element linking these highly co-occurring conditions to negative health outcomes. This study used national VA medical records to examine C-reactive protein (CRP) levels in Iraq/Afghanistan veterans based on presence of mental health and/or sleep disorder diagnoses.
Methods
We examined medical records for 16,576 Iraq/Afghanistan veterans under age 55 who had high-sensitivity CRP results reported. ICD diagnostic codes were used to compare CRP values for: a) veterans without sleep disorders or mental health diagnoses, b) veterans with mental health disorders only, c) veterans with sleep disorders only, and d) veterans with both conditions. In generalized linear models controlling for demographics, we examined the impact of diagnostic category on continuous CRP value as well as the risk of elevated CRP (>3mg/L).
Results
Veterans with mental health disorders (coeff=.14, p<.001) and comorbid sleep and mental health disorders (coeff=.21, p<.001) had higher continuous CRP values compared to veterans without either condition. Veterans with comorbid sleep and mental health disorders had higher continuous CRP values than veterans with sleep disorders alone (coeff=.22, p<.041); however, there were few patients in the current sample who were diagnosed with sleep disorders alone (n=401, 2.4%). Additionally, veterans with mental health disorders (ARR=1.12, p=.004) and comorbid sleep and mental health disorders (ARR=1.15, p=.001) were more likely to have CRP values >3mg/L compared to veterans without either condition.
Conclusion
Sleep disorders were highly likely to co-occur with mental health disorders in this sample of Iraq/Afghanistan veterans. Mental health disorders and comorbid mental health/sleep disorders were associated with elevated C-reactive protein, indicating these patients are at highest risk for negative health outcomes. Future studies should investigate directionality of relationships among sleep disruption, mental health symptoms, and inflammation.
Support
VA Advanced Fellowship Program in Mental Illness Research and Treatment</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/sleep/zsaa056.1107</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Comorbidity Generalized linear models Medical records Mental disorders Mental health care Proteins Sleep disorders Veterans |
| title | 1112 Mental Health And Sleep Disorders Are Associated With Elevated C-reactive Protein In Returning Veterans |
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