The ESCRT-III molecules regulate the apical targeting of bile salt export pump

Background The bile salt export pump (BSEP) is a pivotal apical/canalicular bile salt transporter in hepatocytes that drives the bile flow. Defects in BSEP function and canalicular expression could lead to a spectrum of cholestatic liver diseases. One prominent manifestation of BSEP-associated chole...

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Veröffentlicht in:	Journal of biomedical science 2021-03, Vol.28 (1), p.19-19, Article 19
Hauptverfasser:	Wu, Shang-Hsin, Chang, Mei-Hwei, Chen, Ya-Hui, Wu, Hui-Lin, Chua, Huey-Huey, Chien, Chin-Sung, Ni, Yen-Hsuan, Chen, Hui-Ling, Chen, Huey-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Animal models Antibodies Apical trafficking Baits Bile Bile salt export pump Cell Biology Cell lines CHMP5 Cholestasis Cloning Defects Deoxycholic acid ESCRT Etiology Exports Fetuses Gallbladder diseases Golgi apparatus Hepatocytes Hepatoma Hybrid systems Immunoprecipitation Laboratories Life Sciences & Biomedicine Liver Liver development Liver diseases Localization Medicine, Research & Experimental Membrane proteins Membrane trafficking Membranes Mutagenesis Mutation Perturbation Plasmids Protein transport Proteins Research & Experimental Medicine Retention Salts Science & Technology Yeasts
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