Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model
Pathological changes after third-generation drug-eluting stent implantation remain unclear. We compared the tissue responses of coronary arteries after the implantation of third-generation abluminal biodegradable-polymer everolimus-eluting stent (3rd EES) and second-generation durable-polymer EES (2...
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| Veröffentlicht in: | Scientific reports 2021-03, Vol.11 (1), p.6281-6281, Article 6281 |
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| creator | Migita, Suguru Kitano, Daisuke Li, Yuxin Koyama, Yutaka Shimodai-Yamada, Sayaka Onishi, Akira Fuchimoto, Daiichiro Suzuki, Shunichi Nakamura, Yoshiyuki Matsuyama, Taka-aki Hirota, Seiichi Sakuma, Masashi Tsujimoto, Masahiko Hirayama, Atsushi Okumura, Yasuo Hao, Hiroyuki |
| description | Pathological changes after third-generation drug-eluting stent implantation remain unclear. We compared the tissue responses of coronary arteries after the implantation of third-generation abluminal biodegradable-polymer everolimus-eluting stent (3rd EES) and second-generation durable-polymer EES (2nd EES) using autopsy specimens and an atherosclerotic porcine model. We compared the histology of stented coronary arteries obtained by autopsy performed 1–10 months after 3rd EES (n (number of cases) = 4, stent-implanted period of 3–7 months) and 2nd EES (n (number of cases) = 9, stent-implanted period of 1–10 months) implantations. The ratio of covered stent struts was higher with 3rd EESs than with 2nd EESs (3rd; 0.824 ± 0.032 vs. 2nd; 0.736 ± 0.022,
p
= 0.035). Low-density lipoprotein receptor knockout minipigs were stented with 3rd or 2nd EES in the coronary arteries and the stented regions were investigated. The fibrin deposition around the 2nd EES was more prominent. Additionally, higher density of smooth muscle cells was confirmed after the 3rd EES implantation. Pathological examination after the 3rd EES demonstrated a combination of less fibrin deposition and more rapid acquisition of well-developed neointima as compared to the 2nd EES at autopsy and the atherosclerotic porcine model. |
| doi_str_mv | 10.1038/s41598-021-85740-2 |
| format | Article |
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p
= 0.035). Low-density lipoprotein receptor knockout minipigs were stented with 3rd or 2nd EES in the coronary arteries and the stented regions were investigated. The fibrin deposition around the 2nd EES was more prominent. Additionally, higher density of smooth muscle cells was confirmed after the 3rd EES implantation. Pathological examination after the 3rd EES demonstrated a combination of less fibrin deposition and more rapid acquisition of well-developed neointima as compared to the 2nd EES at autopsy and the atherosclerotic porcine model.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-85740-2</identifier><identifier>PMID: 33737695</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/154 ; 692/308 ; 692/4019 ; Arteriosclerosis ; Atherosclerosis ; Autopsy ; Biodegradability ; Biodegradation ; Coronary artery ; Coronary vessels ; Drug delivery ; Fibrin ; Histology ; Humanities and Social Sciences ; Implants ; multidisciplinary ; Multidisciplinary Sciences ; Polymers ; Receptor density ; Science ; Science & Technology ; Science & Technology - Other Topics ; Science (multidisciplinary) ; Smooth muscle ; Stents</subject><ispartof>Scientific reports, 2021-03, Vol.11 (1), p.6281-6281, Article 6281</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000667589500017</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c606t-41561b5e4d5f4a26e24cb0b30a2254f88cdf69d12ce639d4ecb6d60439e3fe443</citedby><cites>FETCH-LOGICAL-c606t-41561b5e4d5f4a26e24cb0b30a2254f88cdf69d12ce639d4ecb6d60439e3fe443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973802/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973802/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,41125,42194,51581,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33737695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Migita, Suguru</creatorcontrib><creatorcontrib>Kitano, Daisuke</creatorcontrib><creatorcontrib>Li, Yuxin</creatorcontrib><creatorcontrib>Koyama, Yutaka</creatorcontrib><creatorcontrib>Shimodai-Yamada, Sayaka</creatorcontrib><creatorcontrib>Onishi, Akira</creatorcontrib><creatorcontrib>Fuchimoto, Daiichiro</creatorcontrib><creatorcontrib>Suzuki, Shunichi</creatorcontrib><creatorcontrib>Nakamura, Yoshiyuki</creatorcontrib><creatorcontrib>Matsuyama, Taka-aki</creatorcontrib><creatorcontrib>Hirota, Seiichi</creatorcontrib><creatorcontrib>Sakuma, Masashi</creatorcontrib><creatorcontrib>Tsujimoto, Masahiko</creatorcontrib><creatorcontrib>Hirayama, Atsushi</creatorcontrib><creatorcontrib>Okumura, Yasuo</creatorcontrib><creatorcontrib>Hao, Hiroyuki</creatorcontrib><title>Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>SCI REP-UK</addtitle><addtitle>Sci Rep</addtitle><description>Pathological changes after third-generation drug-eluting stent implantation remain unclear. We compared the tissue responses of coronary arteries after the implantation of third-generation abluminal biodegradable-polymer everolimus-eluting stent (3rd EES) and second-generation durable-polymer EES (2nd EES) using autopsy specimens and an atherosclerotic porcine model. We compared the histology of stented coronary arteries obtained by autopsy performed 1–10 months after 3rd EES (n (number of cases) = 4, stent-implanted period of 3–7 months) and 2nd EES (n (number of cases) = 9, stent-implanted period of 1–10 months) implantations. The ratio of covered stent struts was higher with 3rd EESs than with 2nd EESs (3rd; 0.824 ± 0.032 vs. 2nd; 0.736 ± 0.022,
p
= 0.035). Low-density lipoprotein receptor knockout minipigs were stented with 3rd or 2nd EES in the coronary arteries and the stented regions were investigated. The fibrin deposition around the 2nd EES was more prominent. Additionally, higher density of smooth muscle cells was confirmed after the 3rd EES implantation. Pathological examination after the 3rd EES demonstrated a combination of less fibrin deposition and more rapid acquisition of well-developed neointima as compared to the 2nd EES at autopsy and the atherosclerotic porcine model.</description><subject>631/154</subject><subject>692/308</subject><subject>692/4019</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Autopsy</subject><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>Coronary artery</subject><subject>Coronary vessels</subject><subject>Drug delivery</subject><subject>Fibrin</subject><subject>Histology</subject><subject>Humanities and Social Sciences</subject><subject>Implants</subject><subject>multidisciplinary</subject><subject>Multidisciplinary Sciences</subject><subject>Polymers</subject><subject>Receptor density</subject><subject>Science</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Science 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implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model</title><author>Migita, Suguru ; Kitano, Daisuke ; Li, Yuxin ; Koyama, Yutaka ; Shimodai-Yamada, Sayaka ; Onishi, Akira ; Fuchimoto, Daiichiro ; Suzuki, Shunichi ; Nakamura, Yoshiyuki ; Matsuyama, Taka-aki ; Hirota, Seiichi ; Sakuma, Masashi ; Tsujimoto, Masahiko ; Hirayama, Atsushi ; Okumura, Yasuo ; Hao, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-41561b5e4d5f4a26e24cb0b30a2254f88cdf69d12ce639d4ecb6d60439e3fe443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/154</topic><topic>692/308</topic><topic>692/4019</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Autopsy</topic><topic>Biodegradability</topic><topic>Biodegradation</topic><topic>Coronary artery</topic><topic>Coronary vessels</topic><topic>Drug 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Taka-aki</creatorcontrib><creatorcontrib>Hirota, Seiichi</creatorcontrib><creatorcontrib>Sakuma, Masashi</creatorcontrib><creatorcontrib>Tsujimoto, Masahiko</creatorcontrib><creatorcontrib>Hirayama, Atsushi</creatorcontrib><creatorcontrib>Okumura, Yasuo</creatorcontrib><creatorcontrib>Hao, Hiroyuki</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest 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Yutaka</au><au>Shimodai-Yamada, Sayaka</au><au>Onishi, Akira</au><au>Fuchimoto, Daiichiro</au><au>Suzuki, Shunichi</au><au>Nakamura, Yoshiyuki</au><au>Matsuyama, Taka-aki</au><au>Hirota, Seiichi</au><au>Sakuma, Masashi</au><au>Tsujimoto, Masahiko</au><au>Hirayama, Atsushi</au><au>Okumura, Yasuo</au><au>Hao, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><stitle>SCI REP-UK</stitle><addtitle>Sci Rep</addtitle><date>2021-03-18</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>6281</spage><epage>6281</epage><pages>6281-6281</pages><artnum>6281</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Pathological changes after third-generation drug-eluting stent implantation remain unclear. We compared the tissue responses of coronary arteries after the implantation of third-generation abluminal biodegradable-polymer everolimus-eluting stent (3rd EES) and second-generation durable-polymer EES (2nd EES) using autopsy specimens and an atherosclerotic porcine model. We compared the histology of stented coronary arteries obtained by autopsy performed 1–10 months after 3rd EES (n (number of cases) = 4, stent-implanted period of 3–7 months) and 2nd EES (n (number of cases) = 9, stent-implanted period of 1–10 months) implantations. The ratio of covered stent struts was higher with 3rd EESs than with 2nd EESs (3rd; 0.824 ± 0.032 vs. 2nd; 0.736 ± 0.022,
p
= 0.035). Low-density lipoprotein receptor knockout minipigs were stented with 3rd or 2nd EES in the coronary arteries and the stented regions were investigated. The fibrin deposition around the 2nd EES was more prominent. Additionally, higher density of smooth muscle cells was confirmed after the 3rd EES implantation. Pathological examination after the 3rd EES demonstrated a combination of less fibrin deposition and more rapid acquisition of well-developed neointima as compared to the 2nd EES at autopsy and the atherosclerotic porcine model.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33737695</pmid><doi>10.1038/s41598-021-85740-2</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/154 692/308 692/4019 Arteriosclerosis Atherosclerosis Autopsy Biodegradability Biodegradation Coronary artery Coronary vessels Drug delivery Fibrin Histology Humanities and Social Sciences Implants multidisciplinary Multidisciplinary Sciences Polymers Receptor density Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Smooth muscle Stents |
| title | Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model |
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