Discovery of rare sulfated N -unsubstituted glucosamine based heparan sulfate analogs selectively activating chemokines

Achieving selective inhibition of chemokines with structurally well-defined heparan sulfate (HS) oligosaccharides can provide important insights into cancer cell migration and metastasis. However, HS is highly heterogeneous in chemical composition, which limits its therapeutic use. Here, we report t...

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Veröffentlicht in:	Chemical science (Cambridge) 2021-03, Vol.12 (10), p.3674-3681
Hauptverfasser:	Jain, Prashant, Shanthamurthy, Chethan D, Leviatan Ben-Arye, Shani, Woods, Robert J, Kikkeri, Raghavendra, Padler-Karavani, Vered
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs Cancer Cell adhesion & migration Chemical composition Chemical compounds Chemokines Heparan sulfate Homology Interrogation Oligosaccharides Pharmaceuticals Sulfation Synthesis
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