Two metal complex derivatives of pyridine thiazole ligand: synthesis, characterization and biological activity
In this work, two new metal(II) complexes with ligand based on pyridine thiazolone group, [Zn( L ) 2 (TsO) 2 ]2DMF (1), {[Cd( L )(NO 3 ) 2 H 2 O)]DMF} n (2) (where L = 4-(pyridin-4-yl)-2-(2-(pyridin-2- ylmethylene)hydrazinyl)thiazole), were prepared and characterized by physicochemical and spectros...
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| Veröffentlicht in: | Transition metal chemistry (Weinheim) 2021-03, Vol.46 (3), p.263-272 |
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| creator | Zou, Xunzhong Shi, Pingyi Feng, Ansheng Mei, Meng Li, Yu |
| description | In this work, two new metal(II) complexes with ligand based on pyridine thiazolone group, [Zn(
L
)
2
(TsO)
2
]2DMF
(1),
{[Cd(
L
)(NO
3
)
2
H
2
O)]DMF}
n
(2)
(where
L =
4-(pyridin-4-yl)-2-(2-(pyridin-2- ylmethylene)hydrazinyl)thiazole), were prepared and characterized by physicochemical and spectroscopic methods. In addition, the structure of the complexes (
1
and
2
) was confirmed by single-crystal X-ray analysis. Complex
1
has a discrete monomeric structure where
L
acts as a bidentate agent coordinating the zinc(II) atom through pyridine nitrogen and thiazole nitrogen, while complex
2
consists of polymeric {[Cd(
L
)(NO
3
)
2
H
2
O)]DMF}
n
chains in which cadmium(II) atoms are linked by the bridging ligand. The in vitro antimicrobial and antitumor activities of the ligand and complexes (
1 and 2
) were evaluated against seven pathogenic bacterial strains and four human cancer cell lines, and the results showed that some compounds had absolute specificity for certain bacterial strains or cancer cell lines, which thus implied a good application prospect in pharmaceutical use. |
| doi_str_mv | 10.1007/s11243-020-00442-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2501877510</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2501877510</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-53204f1cd4c903980a6a7e068da953eb978e428e904580abfc12faebaf2d927a3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EEuXxA6wssSUwftUJO1TxkiqxKRI7y3Gc1lUaBzstpF-PIUjsWM1i7rmjOQhdELgmAPImEkI5y4BCBsA5zfgBmhAhaVYAeTtEE2AcMk5zcYxOYlwDgKCST1C7-PB4Y3vdYOM3XWM_cWWD2-ne7WzEvsbdEFzlWov7ldN731jcuKVuq1sch7Zf2ejiFTYrHbTpE7lPpG9xCuDS-cYvnUndaed2rh_O0FGtm2jPf-cpen24X8yesvnL4_Psbp4Zlos-E4wCr4mpuCmAFTnoqZYWpnmlC8FsWcjcpmdsAVykZVkbQmttS13TqqBSs1N0OfZ2wb9vbezV2m9Dm04qKoDkUgoCKUXHlAk-xmBr1QW30WFQBNS3VzV6Vcmr-vGqeILYCMUUbpc2_FX_Q30B4-h9Qw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501877510</pqid></control><display><type>article</type><title>Two metal complex derivatives of pyridine thiazole ligand: synthesis, characterization and biological activity</title><source>Springer Nature - Complete Springer Journals</source><creator>Zou, Xunzhong ; Shi, Pingyi ; Feng, Ansheng ; Mei, Meng ; Li, Yu</creator><creatorcontrib>Zou, Xunzhong ; Shi, Pingyi ; Feng, Ansheng ; Mei, Meng ; Li, Yu</creatorcontrib><description>In this work, two new metal(II) complexes with ligand based on pyridine thiazolone group, [Zn(
L
)
2
(TsO)
2
]2DMF
(1),
{[Cd(
L
)(NO
3
)
2
H
2
O)]DMF}
n
(2)
(where
L =
4-(pyridin-4-yl)-2-(2-(pyridin-2- ylmethylene)hydrazinyl)thiazole), were prepared and characterized by physicochemical and spectroscopic methods. In addition, the structure of the complexes (
1
and
2
) was confirmed by single-crystal X-ray analysis. Complex
1
has a discrete monomeric structure where
L
acts as a bidentate agent coordinating the zinc(II) atom through pyridine nitrogen and thiazole nitrogen, while complex
2
consists of polymeric {[Cd(
L
)(NO
3
)
2
H
2
O)]DMF}
n
chains in which cadmium(II) atoms are linked by the bridging ligand. The in vitro antimicrobial and antitumor activities of the ligand and complexes (
1 and 2
) were evaluated against seven pathogenic bacterial strains and four human cancer cell lines, and the results showed that some compounds had absolute specificity for certain bacterial strains or cancer cell lines, which thus implied a good application prospect in pharmaceutical use.</description><identifier>ISSN: 0340-4285</identifier><identifier>EISSN: 1572-901X</identifier><identifier>DOI: 10.1007/s11243-020-00442-4</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Anticancer properties ; Antiinfectives and antibacterials ; Biological activity ; Biotechnology ; Cadmium ; Cancer ; Catalysis ; Chemistry ; Chemistry and Materials Science ; Coordination compounds ; Crystal structure ; Inorganic Chemistry ; Ligands ; Organometallic Chemistry ; Physical Chemistry ; Single crystals ; X ray analysis ; Zinc</subject><ispartof>Transition metal chemistry (Weinheim), 2021-03, Vol.46 (3), p.263-272</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-53204f1cd4c903980a6a7e068da953eb978e428e904580abfc12faebaf2d927a3</citedby><cites>FETCH-LOGICAL-c385t-53204f1cd4c903980a6a7e068da953eb978e428e904580abfc12faebaf2d927a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11243-020-00442-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11243-020-00442-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids></links><search><creatorcontrib>Zou, Xunzhong</creatorcontrib><creatorcontrib>Shi, Pingyi</creatorcontrib><creatorcontrib>Feng, Ansheng</creatorcontrib><creatorcontrib>Mei, Meng</creatorcontrib><creatorcontrib>Li, Yu</creatorcontrib><title>Two metal complex derivatives of pyridine thiazole ligand: synthesis, characterization and biological activity</title><title>Transition metal chemistry (Weinheim)</title><addtitle>Transit Met Chem</addtitle><description>In this work, two new metal(II) complexes with ligand based on pyridine thiazolone group, [Zn(
L
)
2
(TsO)
2
]2DMF
(1),
{[Cd(
L
)(NO
3
)
2
H
2
O)]DMF}
n
(2)
(where
L =
4-(pyridin-4-yl)-2-(2-(pyridin-2- ylmethylene)hydrazinyl)thiazole), were prepared and characterized by physicochemical and spectroscopic methods. In addition, the structure of the complexes (
1
and
2
) was confirmed by single-crystal X-ray analysis. Complex
1
has a discrete monomeric structure where
L
acts as a bidentate agent coordinating the zinc(II) atom through pyridine nitrogen and thiazole nitrogen, while complex
2
consists of polymeric {[Cd(
L
)(NO
3
)
2
H
2
O)]DMF}
n
chains in which cadmium(II) atoms are linked by the bridging ligand. The in vitro antimicrobial and antitumor activities of the ligand and complexes (
1 and 2
) were evaluated against seven pathogenic bacterial strains and four human cancer cell lines, and the results showed that some compounds had absolute specificity for certain bacterial strains or cancer cell lines, which thus implied a good application prospect in pharmaceutical use.</description><subject>Anticancer properties</subject><subject>Antiinfectives and antibacterials</subject><subject>Biological activity</subject><subject>Biotechnology</subject><subject>Cadmium</subject><subject>Cancer</subject><subject>Catalysis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Coordination compounds</subject><subject>Crystal structure</subject><subject>Inorganic Chemistry</subject><subject>Ligands</subject><subject>Organometallic Chemistry</subject><subject>Physical Chemistry</subject><subject>Single crystals</subject><subject>X ray analysis</subject><subject>Zinc</subject><issn>0340-4285</issn><issn>1572-901X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EEuXxA6wssSUwftUJO1TxkiqxKRI7y3Gc1lUaBzstpF-PIUjsWM1i7rmjOQhdELgmAPImEkI5y4BCBsA5zfgBmhAhaVYAeTtEE2AcMk5zcYxOYlwDgKCST1C7-PB4Y3vdYOM3XWM_cWWD2-ne7WzEvsbdEFzlWov7ldN731jcuKVuq1sch7Zf2ejiFTYrHbTpE7lPpG9xCuDS-cYvnUndaed2rh_O0FGtm2jPf-cpen24X8yesvnL4_Psbp4Zlos-E4wCr4mpuCmAFTnoqZYWpnmlC8FsWcjcpmdsAVykZVkbQmttS13TqqBSs1N0OfZ2wb9vbezV2m9Dm04qKoDkUgoCKUXHlAk-xmBr1QW30WFQBNS3VzV6Vcmr-vGqeILYCMUUbpc2_FX_Q30B4-h9Qw</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Zou, Xunzhong</creator><creator>Shi, Pingyi</creator><creator>Feng, Ansheng</creator><creator>Mei, Meng</creator><creator>Li, Yu</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20210301</creationdate><title>Two metal complex derivatives of pyridine thiazole ligand: synthesis, characterization and biological activity</title><author>Zou, Xunzhong ; Shi, Pingyi ; Feng, Ansheng ; Mei, Meng ; Li, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-53204f1cd4c903980a6a7e068da953eb978e428e904580abfc12faebaf2d927a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anticancer properties</topic><topic>Antiinfectives and antibacterials</topic><topic>Biological activity</topic><topic>Biotechnology</topic><topic>Cadmium</topic><topic>Cancer</topic><topic>Catalysis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Coordination compounds</topic><topic>Crystal structure</topic><topic>Inorganic Chemistry</topic><topic>Ligands</topic><topic>Organometallic Chemistry</topic><topic>Physical Chemistry</topic><topic>Single crystals</topic><topic>X ray analysis</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zou, Xunzhong</creatorcontrib><creatorcontrib>Shi, Pingyi</creatorcontrib><creatorcontrib>Feng, Ansheng</creatorcontrib><creatorcontrib>Mei, Meng</creatorcontrib><creatorcontrib>Li, Yu</creatorcontrib><collection>CrossRef</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Transition metal chemistry (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zou, Xunzhong</au><au>Shi, Pingyi</au><au>Feng, Ansheng</au><au>Mei, Meng</au><au>Li, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two metal complex derivatives of pyridine thiazole ligand: synthesis, characterization and biological activity</atitle><jtitle>Transition metal chemistry (Weinheim)</jtitle><stitle>Transit Met Chem</stitle><date>2021-03-01</date><risdate>2021</risdate><volume>46</volume><issue>3</issue><spage>263</spage><epage>272</epage><pages>263-272</pages><issn>0340-4285</issn><eissn>1572-901X</eissn><abstract>In this work, two new metal(II) complexes with ligand based on pyridine thiazolone group, [Zn(
L
)
2
(TsO)
2
]2DMF
(1),
{[Cd(
L
)(NO
3
)
2
H
2
O)]DMF}
n
(2)
(where
L =
4-(pyridin-4-yl)-2-(2-(pyridin-2- ylmethylene)hydrazinyl)thiazole), were prepared and characterized by physicochemical and spectroscopic methods. In addition, the structure of the complexes (
1
and
2
) was confirmed by single-crystal X-ray analysis. Complex
1
has a discrete monomeric structure where
L
acts as a bidentate agent coordinating the zinc(II) atom through pyridine nitrogen and thiazole nitrogen, while complex
2
consists of polymeric {[Cd(
L
)(NO
3
)
2
H
2
O)]DMF}
n
chains in which cadmium(II) atoms are linked by the bridging ligand. The in vitro antimicrobial and antitumor activities of the ligand and complexes (
1 and 2
) were evaluated against seven pathogenic bacterial strains and four human cancer cell lines, and the results showed that some compounds had absolute specificity for certain bacterial strains or cancer cell lines, which thus implied a good application prospect in pharmaceutical use.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11243-020-00442-4</doi><tpages>10</tpages></addata></record> |
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| language | eng |
| recordid | cdi_proquest_journals_2501877510 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Anticancer properties Antiinfectives and antibacterials Biological activity Biotechnology Cadmium Cancer Catalysis Chemistry Chemistry and Materials Science Coordination compounds Crystal structure Inorganic Chemistry Ligands Organometallic Chemistry Physical Chemistry Single crystals X ray analysis Zinc |
| title | Two metal complex derivatives of pyridine thiazole ligand: synthesis, characterization and biological activity |
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