Expression and Function of Somatostatin Receptor Subtype 1 in Human Growth Hormone Secreting Pituitary Tumors Deriving from Patients Partially Responsive or Resistant to Long-Term Treatment with Somatostatin Analogs

The role of somatostatin (SS) receptor subtype 1 (SSTR 1 ) in mediating the inhibitory effect of SS on growth hormone (GH) secreting pituitary tumors has been recently demonstrated. In the present study, we evaluated the effect of the selective SSTR 1 agonist BIM-23745 on in vitro GH secretion in GH...

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Veröffentlicht in:	Neuroendocrinology 2004-03, Vol.79 (3), p.142-148
Hauptverfasser:	Matrone, C., Pivonello, R., Colao, A., Cappabianca, P., Cavallo, L.M., Del Basso De Caro, M.L., Taylor, J.E., Culler, M.D., Lombardi, G., Di Renzo, G.F., Annunziato, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly - drug therapy Acromegaly - metabolism Adenoma - drug therapy Adenoma - secretion Adult Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Drug Resistance, Neoplasm Female Fundamental and applied biological sciences. Psychology Growth Hormone, Leptin and Ghrelin Human Growth Hormone - secretion Humans In Vitro Techniques Male Middle Aged Octreotide - pharmacology Octreotide - therapeutic use Peptides, Cyclic - therapeutic use Pituitary Neoplasms - drug therapy Pituitary Neoplasms - secretion Receptors, Somatostatin - agonists Receptors, Somatostatin - antagonists & inhibitors Receptors, Somatostatin - metabolism Somatostatin - analogs & derivatives Somatostatin - pharmacology Somatostatin - therapeutic use Vertebrates: endocrinology
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