In vitro and in silico assessment of antitumor properties and biomolecular binding studies for two new complexes based on NiII bearing k2N,S-donor ligands

This work deals with two new molecule-based materials, namely NiII-complexes of general formulae [Ni(L1)2] (Ni1) and [Ni(L2)2] (Ni2), where L1 = trans-cinnamaldehyde-N(4)-methyl thiosemicarbazone and L2 = trans-cinnamaldehyde-N(4)-ethyl thiosemicarbazone, as potential antitumor agents. Both compound...

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Veröffentlicht in:	Materials Science & Engineering C 2021-02, Vol.121, p.111815, Article 111815
Hauptverfasser:	Farias, R.L., Polez, A.M.R., Silva, D.E.S., Zanetti, R.D., Moreira, M.B., Batista, V.S., Reis, B.L., Nascimento-Júnior, N.M., Rocha, F.V., Lima, M.A., Oliveira, A.B., Ellena, J., Scarim, C.B., Zambom, C.R., Brito, L.D., Garrido, S.S., Melo, A.P.L., Bresolin, L., Tirloni, B., Pereira, J.C.M., Netto, A.V.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antioxidants Antitumor agents Assaying Binding Biotechnology Chemical analysis Cinnamaldehyde Circular dichroism Cisplatin Coordination compounds Crystal structure Cytotoxicity Deoxyribonucleic acid Dichroism DNA Electrophoresis Emission analysis Erythrocytes Fibroblasts Grooves Human serum albumin Ligands Materials science Metal complexes Metallodrugs mMolecular docking Molecular structure N,S-donor ligands Nickel(II)-complexes NMR Nuclear magnetic resonance Protein-ligand binding studies Scavenging Serum albumin Single crystals Spectrophotometry Toxicity Tryptophan Tumor cell lines Tumors Warfarin X-ray diffraction
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