Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

Cytokine release syndrome (CRS) is a major cause of the multi-organ injury and fatal outcome induced by SARS-CoV-2 infection in severe COVID-19 patients. Metabolism can modulate the immune responses against infectious diseases, yet our understanding remains limited on how host metabolism correlates...

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Veröffentlicht in:	Nature communications 2021-03, Vol.12 (1), p.1618-1618, Article 1618
Hauptverfasser:	Xiao, Nan, Nie, Meng, Pang, Huanhuan, Wang, Bohong, Hu, Jieli, Meng, Xiangjun, Li, Ke, Ran, Xiaorong, Long, Quanxin, Deng, Haijun, Chen, Na, Li, Shao, Tang, Ni, Huang, Ailong, Hu, Zeping
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 631/250/127 631/326/596/4130 631/45/320 692/53/2422 82/58 Animals Arginine Case-Control Studies Chemokines Cohort Studies Coronaviruses Correlation analysis COVID-19 COVID-19 - immunology COVID-19 - metabolism COVID-19 - therapy Crosstalk Cytokine Release Syndrome - immunology Cytokine Release Syndrome - metabolism Cytokine Release Syndrome - therapy Cytokines Cytokines - blood Female Follow-Up Studies Humanities and Social Sciences Humans IL-1β Immune response Immune system In Vitro Techniques Infectious diseases Inflammation Inflammation Mediators - blood Interleukin 6 Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Longitudinal Studies Macaca mulatta Macrophage colony-stimulating factor Male Metabolic Networks and Pathways Metabolic pathways Metabolism Metabolites Metabolome Metabolomics multidisciplinary Multidisciplinary Sciences Pandemics Peripheral blood mononuclear cells SARS-CoV-2 Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Therapeutic targets Tryptophan
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