Antifungal activity of Euphorbia species against moulds responsible of cereal ear rots
Aims This work aimed to identify secondary metabolites from aerial parts of Euphorbia species functional for control of toxigenic Fusarium species responsible of cereal grain rots. Methods and Results Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentiall...
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Veröffentlicht in: | Journal of applied microbiology 2021-04, Vol.130 (4), p.1285-1293 |
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creator | Jiménez, C.M. Álvarez, H.L. Ballari, M.S. Labadié, G.R. Catalán, C.A.N. Toso, R.E. Sampietro, D.A. |
description | Aims
This work aimed to identify secondary metabolites from aerial parts of Euphorbia species functional for control of toxigenic Fusarium species responsible of cereal grain rots.
Methods and Results
Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentially extracted with hexane, ethyl acetate and methanol. The extracts were tested against strains of Fusarium verticillioides and Fusarium graminearum by microdilution tests. The hexane extract of E. collina provided the lowest IC50s on both fungal species. Further fractionation showed that cycloartenol (CA) and 24‐methylenecycloartanol are associated to the moderate inhibitory effect of the hexane extract on fungal growth.Sublethal concentrations of CA and 24MCA blocked deoxynivalenol (DON) and fumonisins production.CA and 24MCA co‐applied with potassium sorbate, a food preservative used for Fusarium control, synergized the growth inhibition of fungi. The mixtures reduced mycotoxins accumulation when applied at sublethal concentrations.
Conclusions
CA and 24MCA inhibited both fungal growth and mycotoxins production. This fact is an advantage respect to potassium sorbate which increased the mycotoxins accumulation at sublethal concentrations.
Significance and Impact of the Study
CA and 24MCA synergized potassium sorbate and their mixtures offer a lower mycotoxigenic risk than potassium sorbate for control of the Fusarium species. |
doi_str_mv | 10.1111/jam.14860 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2500444428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2500444428</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2680-57a46a1958df84d1c56bd3cc28e07e9d7f685e861039b26792895412d4cd96633</originalsourceid><addsrcrecordid>eNp1kL1OwzAURi0EoqUw8ALIEhNDWtuxHXusqvInEAuwWo7jFFdpEuwE1LfHbQob33LvcHSu7gfAJUZTHDNb680UU8HRERjjlLOE8Iwc73eaMJSRETgLYY0QThHjp2CUEskly-gYvM_rzpV9vdIV1KZzX67bwqaEy779aHzuNAytNc4GqFfa1aGDm6avigC9DW1TB5dXdscb621UWO2hb7pwDk5KXQV7cZgT8Ha7fF3cJ08vdw-L-VNiCBcoYZmmXGPJRFEKWmDDeF6kxhBhUWZlkZVcMCs4RqnM41OSCMkoJgU1heQ8TSfgevC2vvnsbejUuul9HU8qwhCiMURE6magjG9C8LZUrXcb7bcKI7VrUMUG1b7ByF4djH2-scUf-VtZBGYD8O0qu_3fpB7nz4PyBwGWeZs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2500444428</pqid></control><display><type>article</type><title>Antifungal activity of Euphorbia species against moulds responsible of cereal ear rots</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Jiménez, C.M. ; Álvarez, H.L. ; Ballari, M.S. ; Labadié, G.R. ; Catalán, C.A.N. ; Toso, R.E. ; Sampietro, D.A.</creator><creatorcontrib>Jiménez, C.M. ; Álvarez, H.L. ; Ballari, M.S. ; Labadié, G.R. ; Catalán, C.A.N. ; Toso, R.E. ; Sampietro, D.A.</creatorcontrib><description>Aims
This work aimed to identify secondary metabolites from aerial parts of Euphorbia species functional for control of toxigenic Fusarium species responsible of cereal grain rots.
Methods and Results
Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentially extracted with hexane, ethyl acetate and methanol. The extracts were tested against strains of Fusarium verticillioides and Fusarium graminearum by microdilution tests. The hexane extract of E. collina provided the lowest IC50s on both fungal species. Further fractionation showed that cycloartenol (CA) and 24‐methylenecycloartanol are associated to the moderate inhibitory effect of the hexane extract on fungal growth.Sublethal concentrations of CA and 24MCA blocked deoxynivalenol (DON) and fumonisins production.CA and 24MCA co‐applied with potassium sorbate, a food preservative used for Fusarium control, synergized the growth inhibition of fungi. The mixtures reduced mycotoxins accumulation when applied at sublethal concentrations.
Conclusions
CA and 24MCA inhibited both fungal growth and mycotoxins production. This fact is an advantage respect to potassium sorbate which increased the mycotoxins accumulation at sublethal concentrations.
Significance and Impact of the Study
CA and 24MCA synergized potassium sorbate and their mixtures offer a lower mycotoxigenic risk than potassium sorbate for control of the Fusarium species.</description><identifier>ISSN: 1364-5072</identifier><identifier>EISSN: 1365-2672</identifier><identifier>DOI: 10.1111/jam.14860</identifier><identifier>PMID: 32969574</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Accumulation ; Acetic acid ; agriculture ; Antifungal activity ; Antifungal agents ; Antifungal Agents - pharmacology ; biotechnology ; Deoxynivalenol ; Edible Grain - microbiology ; Ethyl acetate ; Euphorbia ; Euphorbia - chemistry ; Euphorbia - classification ; Food Preservatives - pharmacology ; food safety ; Fractionation ; Fumonisins ; Fumonisins - metabolism ; Fungi ; Fungicides ; Fusarium ; Fusarium - drug effects ; Fusarium - growth & development ; Fusarium - metabolism ; Fusarium graminearum ; Hexanes ; Metabolites ; Mycotoxins ; Mycotoxins - metabolism ; Plant Extracts - pharmacology ; Potassium ; Potassium sorbate ; Preservatives ; Secondary Metabolism ; Secondary metabolites ; Species</subject><ispartof>Journal of applied microbiology, 2021-04, Vol.130 (4), p.1285-1293</ispartof><rights>2020 The Society for Applied Microbiology</rights><rights>2020 The Society for Applied Microbiology.</rights><rights>Copyright © 2021 The Society for Applied Microbiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2680-57a46a1958df84d1c56bd3cc28e07e9d7f685e861039b26792895412d4cd96633</citedby><cites>FETCH-LOGICAL-c2680-57a46a1958df84d1c56bd3cc28e07e9d7f685e861039b26792895412d4cd96633</cites><orcidid>0000-0002-5598-6060 ; 0000-0003-2956-7484 ; 0000-0003-2467-1573</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjam.14860$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjam.14860$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32969574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiménez, C.M.</creatorcontrib><creatorcontrib>Álvarez, H.L.</creatorcontrib><creatorcontrib>Ballari, M.S.</creatorcontrib><creatorcontrib>Labadié, G.R.</creatorcontrib><creatorcontrib>Catalán, C.A.N.</creatorcontrib><creatorcontrib>Toso, R.E.</creatorcontrib><creatorcontrib>Sampietro, D.A.</creatorcontrib><title>Antifungal activity of Euphorbia species against moulds responsible of cereal ear rots</title><title>Journal of applied microbiology</title><addtitle>J Appl Microbiol</addtitle><description>Aims
This work aimed to identify secondary metabolites from aerial parts of Euphorbia species functional for control of toxigenic Fusarium species responsible of cereal grain rots.
Methods and Results
Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentially extracted with hexane, ethyl acetate and methanol. The extracts were tested against strains of Fusarium verticillioides and Fusarium graminearum by microdilution tests. The hexane extract of E. collina provided the lowest IC50s on both fungal species. Further fractionation showed that cycloartenol (CA) and 24‐methylenecycloartanol are associated to the moderate inhibitory effect of the hexane extract on fungal growth.Sublethal concentrations of CA and 24MCA blocked deoxynivalenol (DON) and fumonisins production.CA and 24MCA co‐applied with potassium sorbate, a food preservative used for Fusarium control, synergized the growth inhibition of fungi. The mixtures reduced mycotoxins accumulation when applied at sublethal concentrations.
Conclusions
CA and 24MCA inhibited both fungal growth and mycotoxins production. This fact is an advantage respect to potassium sorbate which increased the mycotoxins accumulation at sublethal concentrations.
Significance and Impact of the Study
CA and 24MCA synergized potassium sorbate and their mixtures offer a lower mycotoxigenic risk than potassium sorbate for control of the Fusarium species.</description><subject>Accumulation</subject><subject>Acetic acid</subject><subject>agriculture</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>biotechnology</subject><subject>Deoxynivalenol</subject><subject>Edible Grain - microbiology</subject><subject>Ethyl acetate</subject><subject>Euphorbia</subject><subject>Euphorbia - chemistry</subject><subject>Euphorbia - classification</subject><subject>Food Preservatives - pharmacology</subject><subject>food safety</subject><subject>Fractionation</subject><subject>Fumonisins</subject><subject>Fumonisins - metabolism</subject><subject>Fungi</subject><subject>Fungicides</subject><subject>Fusarium</subject><subject>Fusarium - drug effects</subject><subject>Fusarium - growth & development</subject><subject>Fusarium - metabolism</subject><subject>Fusarium graminearum</subject><subject>Hexanes</subject><subject>Metabolites</subject><subject>Mycotoxins</subject><subject>Mycotoxins - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Potassium</subject><subject>Potassium sorbate</subject><subject>Preservatives</subject><subject>Secondary Metabolism</subject><subject>Secondary metabolites</subject><subject>Species</subject><issn>1364-5072</issn><issn>1365-2672</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1OwzAURi0EoqUw8ALIEhNDWtuxHXusqvInEAuwWo7jFFdpEuwE1LfHbQob33LvcHSu7gfAJUZTHDNb680UU8HRERjjlLOE8Iwc73eaMJSRETgLYY0QThHjp2CUEskly-gYvM_rzpV9vdIV1KZzX67bwqaEy779aHzuNAytNc4GqFfa1aGDm6avigC9DW1TB5dXdscb621UWO2hb7pwDk5KXQV7cZgT8Ha7fF3cJ08vdw-L-VNiCBcoYZmmXGPJRFEKWmDDeF6kxhBhUWZlkZVcMCs4RqnM41OSCMkoJgU1heQ8TSfgevC2vvnsbejUuul9HU8qwhCiMURE6magjG9C8LZUrXcb7bcKI7VrUMUG1b7ByF4djH2-scUf-VtZBGYD8O0qu_3fpB7nz4PyBwGWeZs</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Jiménez, C.M.</creator><creator>Álvarez, H.L.</creator><creator>Ballari, M.S.</creator><creator>Labadié, G.R.</creator><creator>Catalán, C.A.N.</creator><creator>Toso, R.E.</creator><creator>Sampietro, D.A.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-5598-6060</orcidid><orcidid>https://orcid.org/0000-0003-2956-7484</orcidid><orcidid>https://orcid.org/0000-0003-2467-1573</orcidid></search><sort><creationdate>202104</creationdate><title>Antifungal activity of Euphorbia species against moulds responsible of cereal ear rots</title><author>Jiménez, C.M. ; Álvarez, H.L. ; Ballari, M.S. ; Labadié, G.R. ; Catalán, C.A.N. ; Toso, R.E. ; Sampietro, D.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2680-57a46a1958df84d1c56bd3cc28e07e9d7f685e861039b26792895412d4cd96633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Accumulation</topic><topic>Acetic acid</topic><topic>agriculture</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>biotechnology</topic><topic>Deoxynivalenol</topic><topic>Edible Grain - microbiology</topic><topic>Ethyl acetate</topic><topic>Euphorbia</topic><topic>Euphorbia - chemistry</topic><topic>Euphorbia - classification</topic><topic>Food Preservatives - pharmacology</topic><topic>food safety</topic><topic>Fractionation</topic><topic>Fumonisins</topic><topic>Fumonisins - metabolism</topic><topic>Fungi</topic><topic>Fungicides</topic><topic>Fusarium</topic><topic>Fusarium - drug effects</topic><topic>Fusarium - growth & development</topic><topic>Fusarium - metabolism</topic><topic>Fusarium graminearum</topic><topic>Hexanes</topic><topic>Metabolites</topic><topic>Mycotoxins</topic><topic>Mycotoxins - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Potassium</topic><topic>Potassium sorbate</topic><topic>Preservatives</topic><topic>Secondary Metabolism</topic><topic>Secondary metabolites</topic><topic>Species</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiménez, C.M.</creatorcontrib><creatorcontrib>Álvarez, H.L.</creatorcontrib><creatorcontrib>Ballari, M.S.</creatorcontrib><creatorcontrib>Labadié, G.R.</creatorcontrib><creatorcontrib>Catalán, C.A.N.</creatorcontrib><creatorcontrib>Toso, R.E.</creatorcontrib><creatorcontrib>Sampietro, D.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiménez, C.M.</au><au>Álvarez, H.L.</au><au>Ballari, M.S.</au><au>Labadié, G.R.</au><au>Catalán, C.A.N.</au><au>Toso, R.E.</au><au>Sampietro, D.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antifungal activity of Euphorbia species against moulds responsible of cereal ear rots</atitle><jtitle>Journal of applied microbiology</jtitle><addtitle>J Appl Microbiol</addtitle><date>2021-04</date><risdate>2021</risdate><volume>130</volume><issue>4</issue><spage>1285</spage><epage>1293</epage><pages>1285-1293</pages><issn>1364-5072</issn><eissn>1365-2672</eissn><abstract>Aims
This work aimed to identify secondary metabolites from aerial parts of Euphorbia species functional for control of toxigenic Fusarium species responsible of cereal grain rots.
Methods and Results
Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentially extracted with hexane, ethyl acetate and methanol. The extracts were tested against strains of Fusarium verticillioides and Fusarium graminearum by microdilution tests. The hexane extract of E. collina provided the lowest IC50s on both fungal species. Further fractionation showed that cycloartenol (CA) and 24‐methylenecycloartanol are associated to the moderate inhibitory effect of the hexane extract on fungal growth.Sublethal concentrations of CA and 24MCA blocked deoxynivalenol (DON) and fumonisins production.CA and 24MCA co‐applied with potassium sorbate, a food preservative used for Fusarium control, synergized the growth inhibition of fungi. The mixtures reduced mycotoxins accumulation when applied at sublethal concentrations.
Conclusions
CA and 24MCA inhibited both fungal growth and mycotoxins production. This fact is an advantage respect to potassium sorbate which increased the mycotoxins accumulation at sublethal concentrations.
Significance and Impact of the Study
CA and 24MCA synergized potassium sorbate and their mixtures offer a lower mycotoxigenic risk than potassium sorbate for control of the Fusarium species.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32969574</pmid><doi>10.1111/jam.14860</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5598-6060</orcidid><orcidid>https://orcid.org/0000-0003-2956-7484</orcidid><orcidid>https://orcid.org/0000-0003-2467-1573</orcidid></addata></record> |
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source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
subjects | Accumulation Acetic acid agriculture Antifungal activity Antifungal agents Antifungal Agents - pharmacology biotechnology Deoxynivalenol Edible Grain - microbiology Ethyl acetate Euphorbia Euphorbia - chemistry Euphorbia - classification Food Preservatives - pharmacology food safety Fractionation Fumonisins Fumonisins - metabolism Fungi Fungicides Fusarium Fusarium - drug effects Fusarium - growth & development Fusarium - metabolism Fusarium graminearum Hexanes Metabolites Mycotoxins Mycotoxins - metabolism Plant Extracts - pharmacology Potassium Potassium sorbate Preservatives Secondary Metabolism Secondary metabolites Species |
title | Antifungal activity of Euphorbia species against moulds responsible of cereal ear rots |
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