Antifungal activity of Euphorbia species against moulds responsible of cereal ear rots

Aims This work aimed to identify secondary metabolites from aerial parts of Euphorbia species functional for control of toxigenic Fusarium species responsible of cereal grain rots. Methods and Results Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentiall...

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Veröffentlicht in:Journal of applied microbiology 2021-04, Vol.130 (4), p.1285-1293
Hauptverfasser: Jiménez, C.M., Álvarez, H.L., Ballari, M.S., Labadié, G.R., Catalán, C.A.N., Toso, R.E., Sampietro, D.A.
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container_end_page 1293
container_issue 4
container_start_page 1285
container_title Journal of applied microbiology
container_volume 130
creator Jiménez, C.M.
Álvarez, H.L.
Ballari, M.S.
Labadié, G.R.
Catalán, C.A.N.
Toso, R.E.
Sampietro, D.A.
description Aims This work aimed to identify secondary metabolites from aerial parts of Euphorbia species functional for control of toxigenic Fusarium species responsible of cereal grain rots. Methods and Results Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentially extracted with hexane, ethyl acetate and methanol. The extracts were tested against strains of Fusarium verticillioides and Fusarium graminearum by microdilution tests. The hexane extract of E. collina provided the lowest IC50s on both fungal species. Further fractionation showed that cycloartenol (CA) and 24‐methylenecycloartanol are associated to the moderate inhibitory effect of the hexane extract on fungal growth.Sublethal concentrations of CA and 24MCA blocked deoxynivalenol (DON) and fumonisins production.CA and 24MCA co‐applied with potassium sorbate, a food preservative used for Fusarium control, synergized the growth inhibition of fungi. The mixtures reduced mycotoxins accumulation when applied at sublethal concentrations. Conclusions CA and 24MCA inhibited both fungal growth and mycotoxins production. This fact is an advantage respect to potassium sorbate which increased the mycotoxins accumulation at sublethal concentrations. Significance and Impact of the Study CA and 24MCA synergized potassium sorbate and their mixtures offer a lower mycotoxigenic risk than potassium sorbate for control of the Fusarium species.
doi_str_mv 10.1111/jam.14860
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Methods and Results Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentially extracted with hexane, ethyl acetate and methanol. The extracts were tested against strains of Fusarium verticillioides and Fusarium graminearum by microdilution tests. The hexane extract of E. collina provided the lowest IC50s on both fungal species. Further fractionation showed that cycloartenol (CA) and 24‐methylenecycloartanol are associated to the moderate inhibitory effect of the hexane extract on fungal growth.Sublethal concentrations of CA and 24MCA blocked deoxynivalenol (DON) and fumonisins production.CA and 24MCA co‐applied with potassium sorbate, a food preservative used for Fusarium control, synergized the growth inhibition of fungi. The mixtures reduced mycotoxins accumulation when applied at sublethal concentrations. Conclusions CA and 24MCA inhibited both fungal growth and mycotoxins production. This fact is an advantage respect to potassium sorbate which increased the mycotoxins accumulation at sublethal concentrations. Significance and Impact of the Study CA and 24MCA synergized potassium sorbate and their mixtures offer a lower mycotoxigenic risk than potassium sorbate for control of the Fusarium species.</description><identifier>ISSN: 1364-5072</identifier><identifier>EISSN: 1365-2672</identifier><identifier>DOI: 10.1111/jam.14860</identifier><identifier>PMID: 32969574</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Accumulation ; Acetic acid ; agriculture ; Antifungal activity ; Antifungal agents ; Antifungal Agents - pharmacology ; biotechnology ; Deoxynivalenol ; Edible Grain - microbiology ; Ethyl acetate ; Euphorbia ; Euphorbia - chemistry ; Euphorbia - classification ; Food Preservatives - pharmacology ; food safety ; Fractionation ; Fumonisins ; Fumonisins - metabolism ; Fungi ; Fungicides ; Fusarium ; Fusarium - drug effects ; Fusarium - growth &amp; development ; Fusarium - metabolism ; Fusarium graminearum ; Hexanes ; Metabolites ; Mycotoxins ; Mycotoxins - metabolism ; Plant Extracts - pharmacology ; Potassium ; Potassium sorbate ; Preservatives ; Secondary Metabolism ; Secondary metabolites ; Species</subject><ispartof>Journal of applied microbiology, 2021-04, Vol.130 (4), p.1285-1293</ispartof><rights>2020 The Society for Applied Microbiology</rights><rights>2020 The Society for Applied Microbiology.</rights><rights>Copyright © 2021 The Society for Applied Microbiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2680-57a46a1958df84d1c56bd3cc28e07e9d7f685e861039b26792895412d4cd96633</citedby><cites>FETCH-LOGICAL-c2680-57a46a1958df84d1c56bd3cc28e07e9d7f685e861039b26792895412d4cd96633</cites><orcidid>0000-0002-5598-6060 ; 0000-0003-2956-7484 ; 0000-0003-2467-1573</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjam.14860$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjam.14860$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32969574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiménez, C.M.</creatorcontrib><creatorcontrib>Álvarez, H.L.</creatorcontrib><creatorcontrib>Ballari, M.S.</creatorcontrib><creatorcontrib>Labadié, G.R.</creatorcontrib><creatorcontrib>Catalán, C.A.N.</creatorcontrib><creatorcontrib>Toso, R.E.</creatorcontrib><creatorcontrib>Sampietro, D.A.</creatorcontrib><title>Antifungal activity of Euphorbia species against moulds responsible of cereal ear rots</title><title>Journal of applied microbiology</title><addtitle>J Appl Microbiol</addtitle><description>Aims This work aimed to identify secondary metabolites from aerial parts of Euphorbia species functional for control of toxigenic Fusarium species responsible of cereal grain rots. Methods and Results Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentially extracted with hexane, ethyl acetate and methanol. The extracts were tested against strains of Fusarium verticillioides and Fusarium graminearum by microdilution tests. The hexane extract of E. collina provided the lowest IC50s on both fungal species. Further fractionation showed that cycloartenol (CA) and 24‐methylenecycloartanol are associated to the moderate inhibitory effect of the hexane extract on fungal growth.Sublethal concentrations of CA and 24MCA blocked deoxynivalenol (DON) and fumonisins production.CA and 24MCA co‐applied with potassium sorbate, a food preservative used for Fusarium control, synergized the growth inhibition of fungi. The mixtures reduced mycotoxins accumulation when applied at sublethal concentrations. Conclusions CA and 24MCA inhibited both fungal growth and mycotoxins production. This fact is an advantage respect to potassium sorbate which increased the mycotoxins accumulation at sublethal concentrations. 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Methods and Results Aerial parts of Euphorbia serpens, Euphorbia schickendantzii and Euphorbia collina were sequentially extracted with hexane, ethyl acetate and methanol. The extracts were tested against strains of Fusarium verticillioides and Fusarium graminearum by microdilution tests. The hexane extract of E. collina provided the lowest IC50s on both fungal species. Further fractionation showed that cycloartenol (CA) and 24‐methylenecycloartanol are associated to the moderate inhibitory effect of the hexane extract on fungal growth.Sublethal concentrations of CA and 24MCA blocked deoxynivalenol (DON) and fumonisins production.CA and 24MCA co‐applied with potassium sorbate, a food preservative used for Fusarium control, synergized the growth inhibition of fungi. The mixtures reduced mycotoxins accumulation when applied at sublethal concentrations. Conclusions CA and 24MCA inhibited both fungal growth and mycotoxins production. This fact is an advantage respect to potassium sorbate which increased the mycotoxins accumulation at sublethal concentrations. Significance and Impact of the Study CA and 24MCA synergized potassium sorbate and their mixtures offer a lower mycotoxigenic risk than potassium sorbate for control of the Fusarium species.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32969574</pmid><doi>10.1111/jam.14860</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5598-6060</orcidid><orcidid>https://orcid.org/0000-0003-2956-7484</orcidid><orcidid>https://orcid.org/0000-0003-2467-1573</orcidid></addata></record>
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source Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Accumulation
Acetic acid
agriculture
Antifungal activity
Antifungal agents
Antifungal Agents - pharmacology
biotechnology
Deoxynivalenol
Edible Grain - microbiology
Ethyl acetate
Euphorbia
Euphorbia - chemistry
Euphorbia - classification
Food Preservatives - pharmacology
food safety
Fractionation
Fumonisins
Fumonisins - metabolism
Fungi
Fungicides
Fusarium
Fusarium - drug effects
Fusarium - growth & development
Fusarium - metabolism
Fusarium graminearum
Hexanes
Metabolites
Mycotoxins
Mycotoxins - metabolism
Plant Extracts - pharmacology
Potassium
Potassium sorbate
Preservatives
Secondary Metabolism
Secondary metabolites
Species
title Antifungal activity of Euphorbia species against moulds responsible of cereal ear rots
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