Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice

Objective This study aimed to evaluate the effects of ingested periodontal pathogens on experimental colitis in mice and to elucidate its underlying mechanisms. Background Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results in damage to the gastrointestinal...

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Veröffentlicht in:	Journal of periodontal research 2021-04, Vol.56 (2), p.275-288
Hauptverfasser:	Tsuzuno, Takahiro, Takahashi, Naoki, Yamada‐Hara, Miki, Yokoji‐Takeuchi, Mai, Sulijaya, Benso, Aoki‐Nonaka, Yukari, Matsugishi, Aoi, Katakura, Kyoko, Tabeta, Koichi, Yamazaki, Kazuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colitis Colitis - chemically induced Colitis - complications Dextran Drinking water Eating Epidemiology Epithelial cells Fusobacterium nucleatum Gastrointestinal tract Inflammation Inflammatory bowel disease Inflammatory bowel diseases intestinal epithelial cells Intestine Mice Mice, Inbred C57BL Molecular modelling Oral administration Pathogens Periodontitis Permeability Porphyromonas gingivalis Prevotella intermedia Sodium sulfate tight junction proteins
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