Assessment of inappropriate prescribing of QT interval-prolonging drugs in end-stage renal disease patients in Jordan
Background Despite the high risk of life-threatening complications due to drug-induced prolongation of the corrected QT interval (QTcP) in patients with end-stage renal disease (ESRD), the safety of QTcP-inducing drugs has rarely been investigated in this patient population. Objectives This study ai...
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| Veröffentlicht in: | Drugs & therapy perspectives : for rational drug selection and use 2021-02, Vol.37 (2), p.87-93 |
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| creator | Al Meslamani, Ahmad Z. Abu-Naser, Dania Abdel-Qader, Derar H. Aljamal, Mohammed S. Alsharif, Mohammed A Alshrahili, Mohamed Ahmed Mohammed Al Mazrouei, Nadia Ibrahim, Osama Mohamed |
| description | Background
Despite the high risk of life-threatening complications due to drug-induced prolongation of the corrected QT interval (QTcP) in patients with end-stage renal disease (ESRD), the safety of QTcP-inducing drugs has rarely been investigated in this patient population.
Objectives
This study aimed to assess the appropriateness of prescriptions for QTcP-inducing drugs and evaluate potential drug–drug interactions (DDIs) in patients with ESRD in Jordan.
Methods
This study was a retrospective observational study conducted from October 2019 to March 2020 in the outpatient clinics of 36 healthcare facilities across Jordan. A standardized data collection form was developed and used by pharmacy staff to collect data from the electronic databases of these facilities. The targeted population was patients with ESRD, specifically their prescriptions. Micromedex Drug Reax
®
software was used to check potential DDIs. Data were analysed using SPSS v26 software.
Results
The study included 407 patients with ESRD, who were prescribed 954 drugs with a risk of inducing QTcP. Of these, 17.6% were considered inappropriate application, 12.9% inappropriate choice, and 26.4% inappropriate decision. Roughly two-thirds of the dispensed drugs (64.8%) were associated with a DDI, 10.4% of which were major, 29.3% moderate, and 60.3% minor. Predictors for major DDIs were major polypharmacy, type of clinic and geographic location. Predictors for inappropriate prescribing were type of clinic and geographic location.
Conclusion
High rates of DDIs and inappropriate prescribing of QTcP-inducing drugs were reported among patients with ESRD in outpatient clinics in Jordan. |
| doi_str_mv | 10.1007/s40267-020-00806-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2499458537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2499458537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-a082d77eaf6bd28366da78f24ce2f54be63c11c51311e8cb05a69abd81a05f243</originalsourceid><addsrcrecordid>eNp9kM1LxDAQxYMouK7-A54KnqP5aJP2uCx-siDCeg5pMy1dumnNtKL_vdmt4M3TDLzfe8w8Qq45u-WM6TtMmVCaMsEoYzlT9OuELDjXBeWF1qfHXVAmFTsnF4g7Fikl-YJMK0RA3IMfk75OWm-HIfRDaO0IyRAAq9CWrW8O4ts26iOET9vRCHW9bw6KC1ODUUnAO4qjbSAJ4G2XuBbBYoyxYxvzj8xLH5z1l-Ssth3C1e9ckveH--36iW5eH5_Xqw2tJC9GalkunNZga1U6kUulnNV5LdIKRJ2lJShZcV5lXHIOeVWyzKrCli7nlmURk0tyM-fGcz8mwNHs-inE29CItCjSLM-kjpSYqSr0iAFqE__f2_BtODOHes1cr4n1mmO95iua5GzCCPsGwl_0P64fAi6ARQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2499458537</pqid></control><display><type>article</type><title>Assessment of inappropriate prescribing of QT interval-prolonging drugs in end-stage renal disease patients in Jordan</title><source>SpringerLink Journals - AutoHoldings</source><creator>Al Meslamani, Ahmad Z. ; Abu-Naser, Dania ; Abdel-Qader, Derar H. ; Aljamal, Mohammed S. ; Alsharif, Mohammed A ; Alshrahili, Mohamed Ahmed Mohammed ; Al Mazrouei, Nadia ; Ibrahim, Osama Mohamed</creator><creatorcontrib>Al Meslamani, Ahmad Z. ; Abu-Naser, Dania ; Abdel-Qader, Derar H. ; Aljamal, Mohammed S. ; Alsharif, Mohammed A ; Alshrahili, Mohamed Ahmed Mohammed ; Al Mazrouei, Nadia ; Ibrahim, Osama Mohamed</creatorcontrib><description>Background
Despite the high risk of life-threatening complications due to drug-induced prolongation of the corrected QT interval (QTcP) in patients with end-stage renal disease (ESRD), the safety of QTcP-inducing drugs has rarely been investigated in this patient population.
Objectives
This study aimed to assess the appropriateness of prescriptions for QTcP-inducing drugs and evaluate potential drug–drug interactions (DDIs) in patients with ESRD in Jordan.
Methods
This study was a retrospective observational study conducted from October 2019 to March 2020 in the outpatient clinics of 36 healthcare facilities across Jordan. A standardized data collection form was developed and used by pharmacy staff to collect data from the electronic databases of these facilities. The targeted population was patients with ESRD, specifically their prescriptions. Micromedex Drug Reax
®
software was used to check potential DDIs. Data were analysed using SPSS v26 software.
Results
The study included 407 patients with ESRD, who were prescribed 954 drugs with a risk of inducing QTcP. Of these, 17.6% were considered inappropriate application, 12.9% inappropriate choice, and 26.4% inappropriate decision. Roughly two-thirds of the dispensed drugs (64.8%) were associated with a DDI, 10.4% of which were major, 29.3% moderate, and 60.3% minor. Predictors for major DDIs were major polypharmacy, type of clinic and geographic location. Predictors for inappropriate prescribing were type of clinic and geographic location.
Conclusion
High rates of DDIs and inappropriate prescribing of QTcP-inducing drugs were reported among patients with ESRD in outpatient clinics in Jordan.</description><identifier>ISSN: 1172-0360</identifier><identifier>EISSN: 1179-1977</identifier><identifier>DOI: 10.1007/s40267-020-00806-x</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Clinics ; Congenital diseases ; Data collection ; Drug dosages ; Drug interactions ; Health facilities ; Kidney diseases ; Medicine ; Original Research Article ; Outpatient care facilities ; Patients ; Pharmacotherapy ; Pharmacy ; Polypharmacy ; Prescription drugs ; Software</subject><ispartof>Drugs & therapy perspectives : for rational drug selection and use, 2021-02, Vol.37 (2), p.87-93</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021</rights><rights>Copyright Springer Nature B.V. Feb 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-a082d77eaf6bd28366da78f24ce2f54be63c11c51311e8cb05a69abd81a05f243</citedby><cites>FETCH-LOGICAL-c319t-a082d77eaf6bd28366da78f24ce2f54be63c11c51311e8cb05a69abd81a05f243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40267-020-00806-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40267-020-00806-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Al Meslamani, Ahmad Z.</creatorcontrib><creatorcontrib>Abu-Naser, Dania</creatorcontrib><creatorcontrib>Abdel-Qader, Derar H.</creatorcontrib><creatorcontrib>Aljamal, Mohammed S.</creatorcontrib><creatorcontrib>Alsharif, Mohammed A</creatorcontrib><creatorcontrib>Alshrahili, Mohamed Ahmed Mohammed</creatorcontrib><creatorcontrib>Al Mazrouei, Nadia</creatorcontrib><creatorcontrib>Ibrahim, Osama Mohamed</creatorcontrib><title>Assessment of inappropriate prescribing of QT interval-prolonging drugs in end-stage renal disease patients in Jordan</title><title>Drugs & therapy perspectives : for rational drug selection and use</title><addtitle>Drugs Ther Perspect</addtitle><description>Background
Despite the high risk of life-threatening complications due to drug-induced prolongation of the corrected QT interval (QTcP) in patients with end-stage renal disease (ESRD), the safety of QTcP-inducing drugs has rarely been investigated in this patient population.
Objectives
This study aimed to assess the appropriateness of prescriptions for QTcP-inducing drugs and evaluate potential drug–drug interactions (DDIs) in patients with ESRD in Jordan.
Methods
This study was a retrospective observational study conducted from October 2019 to March 2020 in the outpatient clinics of 36 healthcare facilities across Jordan. A standardized data collection form was developed and used by pharmacy staff to collect data from the electronic databases of these facilities. The targeted population was patients with ESRD, specifically their prescriptions. Micromedex Drug Reax
®
software was used to check potential DDIs. Data were analysed using SPSS v26 software.
Results
The study included 407 patients with ESRD, who were prescribed 954 drugs with a risk of inducing QTcP. Of these, 17.6% were considered inappropriate application, 12.9% inappropriate choice, and 26.4% inappropriate decision. Roughly two-thirds of the dispensed drugs (64.8%) were associated with a DDI, 10.4% of which were major, 29.3% moderate, and 60.3% minor. Predictors for major DDIs were major polypharmacy, type of clinic and geographic location. Predictors for inappropriate prescribing were type of clinic and geographic location.
Conclusion
High rates of DDIs and inappropriate prescribing of QTcP-inducing drugs were reported among patients with ESRD in outpatient clinics in Jordan.</description><subject>Clinics</subject><subject>Congenital diseases</subject><subject>Data collection</subject><subject>Drug dosages</subject><subject>Drug interactions</subject><subject>Health facilities</subject><subject>Kidney diseases</subject><subject>Medicine</subject><subject>Original Research Article</subject><subject>Outpatient care facilities</subject><subject>Patients</subject><subject>Pharmacotherapy</subject><subject>Pharmacy</subject><subject>Polypharmacy</subject><subject>Prescription drugs</subject><subject>Software</subject><issn>1172-0360</issn><issn>1179-1977</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kM1LxDAQxYMouK7-A54KnqP5aJP2uCx-siDCeg5pMy1dumnNtKL_vdmt4M3TDLzfe8w8Qq45u-WM6TtMmVCaMsEoYzlT9OuELDjXBeWF1qfHXVAmFTsnF4g7Fikl-YJMK0RA3IMfk75OWm-HIfRDaO0IyRAAq9CWrW8O4ts26iOET9vRCHW9bw6KC1ODUUnAO4qjbSAJ4G2XuBbBYoyxYxvzj8xLH5z1l-Ssth3C1e9ckveH--36iW5eH5_Xqw2tJC9GalkunNZga1U6kUulnNV5LdIKRJ2lJShZcV5lXHIOeVWyzKrCli7nlmURk0tyM-fGcz8mwNHs-inE29CItCjSLM-kjpSYqSr0iAFqE__f2_BtODOHes1cr4n1mmO95iua5GzCCPsGwl_0P64fAi6ARQ</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Al Meslamani, Ahmad Z.</creator><creator>Abu-Naser, Dania</creator><creator>Abdel-Qader, Derar H.</creator><creator>Aljamal, Mohammed S.</creator><creator>Alsharif, Mohammed A</creator><creator>Alshrahili, Mohamed Ahmed Mohammed</creator><creator>Al Mazrouei, Nadia</creator><creator>Ibrahim, Osama Mohamed</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20210201</creationdate><title>Assessment of inappropriate prescribing of QT interval-prolonging drugs in end-stage renal disease patients in Jordan</title><author>Al Meslamani, Ahmad Z. ; Abu-Naser, Dania ; Abdel-Qader, Derar H. ; Aljamal, Mohammed S. ; Alsharif, Mohammed A ; Alshrahili, Mohamed Ahmed Mohammed ; Al Mazrouei, Nadia ; Ibrahim, Osama Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-a082d77eaf6bd28366da78f24ce2f54be63c11c51311e8cb05a69abd81a05f243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Clinics</topic><topic>Congenital diseases</topic><topic>Data collection</topic><topic>Drug dosages</topic><topic>Drug interactions</topic><topic>Health facilities</topic><topic>Kidney diseases</topic><topic>Medicine</topic><topic>Original Research Article</topic><topic>Outpatient care facilities</topic><topic>Patients</topic><topic>Pharmacotherapy</topic><topic>Pharmacy</topic><topic>Polypharmacy</topic><topic>Prescription drugs</topic><topic>Software</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al Meslamani, Ahmad Z.</creatorcontrib><creatorcontrib>Abu-Naser, Dania</creatorcontrib><creatorcontrib>Abdel-Qader, Derar H.</creatorcontrib><creatorcontrib>Aljamal, Mohammed S.</creatorcontrib><creatorcontrib>Alsharif, Mohammed A</creatorcontrib><creatorcontrib>Alshrahili, Mohamed Ahmed Mohammed</creatorcontrib><creatorcontrib>Al Mazrouei, Nadia</creatorcontrib><creatorcontrib>Ibrahim, Osama Mohamed</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Drugs & therapy perspectives : for rational drug selection and use</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al Meslamani, Ahmad Z.</au><au>Abu-Naser, Dania</au><au>Abdel-Qader, Derar H.</au><au>Aljamal, Mohammed S.</au><au>Alsharif, Mohammed A</au><au>Alshrahili, Mohamed Ahmed Mohammed</au><au>Al Mazrouei, Nadia</au><au>Ibrahim, Osama Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of inappropriate prescribing of QT interval-prolonging drugs in end-stage renal disease patients in Jordan</atitle><jtitle>Drugs & therapy perspectives : for rational drug selection and use</jtitle><stitle>Drugs Ther Perspect</stitle><date>2021-02-01</date><risdate>2021</risdate><volume>37</volume><issue>2</issue><spage>87</spage><epage>93</epage><pages>87-93</pages><issn>1172-0360</issn><eissn>1179-1977</eissn><abstract>Background
Despite the high risk of life-threatening complications due to drug-induced prolongation of the corrected QT interval (QTcP) in patients with end-stage renal disease (ESRD), the safety of QTcP-inducing drugs has rarely been investigated in this patient population.
Objectives
This study aimed to assess the appropriateness of prescriptions for QTcP-inducing drugs and evaluate potential drug–drug interactions (DDIs) in patients with ESRD in Jordan.
Methods
This study was a retrospective observational study conducted from October 2019 to March 2020 in the outpatient clinics of 36 healthcare facilities across Jordan. A standardized data collection form was developed and used by pharmacy staff to collect data from the electronic databases of these facilities. The targeted population was patients with ESRD, specifically their prescriptions. Micromedex Drug Reax
®
software was used to check potential DDIs. Data were analysed using SPSS v26 software.
Results
The study included 407 patients with ESRD, who were prescribed 954 drugs with a risk of inducing QTcP. Of these, 17.6% were considered inappropriate application, 12.9% inappropriate choice, and 26.4% inappropriate decision. Roughly two-thirds of the dispensed drugs (64.8%) were associated with a DDI, 10.4% of which were major, 29.3% moderate, and 60.3% minor. Predictors for major DDIs were major polypharmacy, type of clinic and geographic location. Predictors for inappropriate prescribing were type of clinic and geographic location.
Conclusion
High rates of DDIs and inappropriate prescribing of QTcP-inducing drugs were reported among patients with ESRD in outpatient clinics in Jordan.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s40267-020-00806-x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Drugs & therapy perspectives : for rational drug selection and use, 2021-02, Vol.37 (2), p.87-93 |
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| subjects | Clinics Congenital diseases Data collection Drug dosages Drug interactions Health facilities Kidney diseases Medicine Original Research Article Outpatient care facilities Patients Pharmacotherapy Pharmacy Polypharmacy Prescription drugs Software |
| title | Assessment of inappropriate prescribing of QT interval-prolonging drugs in end-stage renal disease patients in Jordan |
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