SDF-1 mediates mesenchymal stem cell recruitment and migration via the SDF-1/CXCR4 axis in bone defect

Introduction Recent studies have indicated the potential of stem cell therapy in combination with cytokines to restore the bone repair via migration and homing of stem cells to the defected area. The present study aimed to investigate the mobilization and recruitment of mesenchymal stem cells (MSCs)...

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Veröffentlicht in:	Journal of bone and mineral metabolism 2021-03, Vol.39 (2), p.126-138
Hauptverfasser:	Zhang, Heli, Li, Xijing, Li, Junfeng, Zhong, Lili, Chen, Xue, Chen, Si
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biomarkers - metabolism Bone and Bones - diagnostic imaging Bone and Bones - drug effects Bone and Bones - pathology Bone grafts Bone healing Bone Marrow - drug effects Bone Marrow - pathology Bone Transplantation Cell Movement - drug effects Cell therapy Chemokine CXCL12 - pharmacology CXCR4 protein Disease Models, Animal Femur - diagnostic imaging Femur - drug effects Femur - pathology Flow cytometry Homing behavior Male Medicine Medicine & Public Health Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Metabolic Diseases Original Article Orthopedics Osteogenesis - drug effects Osteogenesis - genetics Overexpression Rats Rats, Wistar Receptors, CXCR4 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents SDF-1 protein Signal Transduction - drug effects Stem cell transplantation Stem cells Up-Regulation - drug effects Up-Regulation - genetics
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