Incidence of and Risk Factors for Alcohol Relapse After Liver Transplantation for Alcoholic Liver Disease: Comparison Between Deceased Donor and Living Donor Liver Transplantation
Background There are controversies over whether patients with alcohol-related liver disease (ALD) should follow the “6-month abstinence rule” before undergoing liver transplantation (LT), especially in case of living donor LT (LDLT). We analyzed the risk of alcohol relapse among ALD patients who rec...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2021-03, Vol.25 (3), p.672-680 |
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| creator | Chung, Hye Gyo Sinn, Dong Hyun Kang, Wonseok Choi, Gyu-Seong Kim, Jong Man Joh, Jae-Won |
| description | Background
There are controversies over whether patients with alcohol-related liver disease (ALD) should follow the “6-month abstinence rule” before undergoing liver transplantation (LT), especially in case of living donor LT (LDLT). We analyzed the risk of alcohol relapse among ALD patients who received LT according to donor types and abstinence period before LT.
Methods
A total of 129 patients (mean 50.7 ± 9.2 years, male 78.3%) who underwent LT between January 2000 and July 2017 for ALD at Samsung Medical Center, Seoul, Korea, were analyzed. Alcohol relapse was defined as any use of alcohol after LT.
Results
The alcohol relapse rate was lower in LDLT recipients compared with that in DDLT recipients (13.9% vs. 31.7% at 3 years,
P
= 0.013). DDLT recipient, short abstinence period ( |
| doi_str_mv | 10.1007/s11605-020-04540-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2498796987</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2498796987</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-1afd1498bc86eee33fbd7e0f0ab2b6dec94f6aa0ec03e78752e2bf9d08a44c563</originalsourceid><addsrcrecordid>eNp9kUtrGzEUhUVpaB7tH-giCLqe5Erz0Ex3rt08wBAwLnQnNJqrROlYmkjjlPyu_MHItfNYlGyuxL3fOWdxCPnK4IQBiNPIWAVlBhwyKMoCMvGBHLBa5FlR8epj-kPDMl6Wv_fJYYy3AEwAqz-R_ZxDUzZcHJDHS6dth04j9YYq19GFjX_omdKjD5EaH-ik1_7G93SBvRoi0okZMdC5vU9zGZSLQ6_cqEbr3Vve6h0zsxFVxO906leDCjYm7geOfxEdnaHe3Do68y5JN_lJZN31bvHflM9kz6g-4pfde0R-nf1cTi-y-dX55XQyz3QuyjFjynSsaOpW1xUi5rlpO4FgQLW8rTrUTWEqpQA15ChqUXLkrWk6qFVR6LLKj8i3re8Q_N0a4yhv_Tq4FCl58hVNlUai-JbSwccY0Mgh2JUKD5KB3PQktz3J1JP815PciI531ut2hd2L5LmYBORbIKaTu8bwmv2O7RPvwaHU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2498796987</pqid></control><display><type>article</type><title>Incidence of and Risk Factors for Alcohol Relapse After Liver Transplantation for Alcoholic Liver Disease: Comparison Between Deceased Donor and Living Donor Liver Transplantation</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Chung, Hye Gyo ; Sinn, Dong Hyun ; Kang, Wonseok ; Choi, Gyu-Seong ; Kim, Jong Man ; Joh, Jae-Won</creator><creatorcontrib>Chung, Hye Gyo ; Sinn, Dong Hyun ; Kang, Wonseok ; Choi, Gyu-Seong ; Kim, Jong Man ; Joh, Jae-Won</creatorcontrib><description>Background
There are controversies over whether patients with alcohol-related liver disease (ALD) should follow the “6-month abstinence rule” before undergoing liver transplantation (LT), especially in case of living donor LT (LDLT). We analyzed the risk of alcohol relapse among ALD patients who received LT according to donor types and abstinence period before LT.
Methods
A total of 129 patients (mean 50.7 ± 9.2 years, male 78.3%) who underwent LT between January 2000 and July 2017 for ALD at Samsung Medical Center, Seoul, Korea, were analyzed. Alcohol relapse was defined as any use of alcohol after LT.
Results
The alcohol relapse rate was lower in LDLT recipients compared with that in DDLT recipients (13.9% vs. 31.7% at 3 years,
P
= 0.013). DDLT recipient, short abstinence period (< 6 months), and current smoking status were factors associated with alcohol relapse. The alcohol relapse rate was highest (54.5% at 3 years) for current smokers without 6-month sobriety who received DDLT, and it was lowest for never/ex-smoker with 6-month sobriety who received LDLT (4.3% at 3 years). For LDLT recipients, the alcohol relapse rate was not different according to abstinence period (17.7% vs. 11.6% at 3 years for short abstinent period < 3 months vs. ≥ 3 months,
P
= 0.92), but it was higher for current smokers compared with that for non/ex-smokers (22.4% vs. 5.8% at 3 years,
P
= 0.05).
Conclusion
When considering LDLT for ALD, sobriety period may not be an absolute contraindication as abstinence period showed a weak association with alcohol relapse. Smokers need careful attention for alcohol relapse.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-020-04540-7</identifier><identifier>PMID: 32095927</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alcohol use ; Gastroenterology ; Hepatitis ; Humans ; Incidence ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Liver Diseases, Alcoholic - epidemiology ; Liver Diseases, Alcoholic - surgery ; Liver Transplantation ; Liver transplants ; Living Donors ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Patients ; Recurrence ; Republic of Korea - epidemiology ; Retrospective Studies ; Risk Factors ; Surgery ; Transplants & implants</subject><ispartof>Journal of gastrointestinal surgery, 2021-03, Vol.25 (3), p.672-680</ispartof><rights>The Society for Surgery of the Alimentary Tract 2020</rights><rights>The Society for Surgery of the Alimentary Tract 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1afd1498bc86eee33fbd7e0f0ab2b6dec94f6aa0ec03e78752e2bf9d08a44c563</citedby><cites>FETCH-LOGICAL-c375t-1afd1498bc86eee33fbd7e0f0ab2b6dec94f6aa0ec03e78752e2bf9d08a44c563</cites><orcidid>0000-0002-7126-5554</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-020-04540-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-020-04540-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32095927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Hye Gyo</creatorcontrib><creatorcontrib>Sinn, Dong Hyun</creatorcontrib><creatorcontrib>Kang, Wonseok</creatorcontrib><creatorcontrib>Choi, Gyu-Seong</creatorcontrib><creatorcontrib>Kim, Jong Man</creatorcontrib><creatorcontrib>Joh, Jae-Won</creatorcontrib><title>Incidence of and Risk Factors for Alcohol Relapse After Liver Transplantation for Alcoholic Liver Disease: Comparison Between Deceased Donor and Living Donor Liver Transplantation</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Background
There are controversies over whether patients with alcohol-related liver disease (ALD) should follow the “6-month abstinence rule” before undergoing liver transplantation (LT), especially in case of living donor LT (LDLT). We analyzed the risk of alcohol relapse among ALD patients who received LT according to donor types and abstinence period before LT.
Methods
A total of 129 patients (mean 50.7 ± 9.2 years, male 78.3%) who underwent LT between January 2000 and July 2017 for ALD at Samsung Medical Center, Seoul, Korea, were analyzed. Alcohol relapse was defined as any use of alcohol after LT.
Results
The alcohol relapse rate was lower in LDLT recipients compared with that in DDLT recipients (13.9% vs. 31.7% at 3 years,
P
= 0.013). DDLT recipient, short abstinence period (< 6 months), and current smoking status were factors associated with alcohol relapse. The alcohol relapse rate was highest (54.5% at 3 years) for current smokers without 6-month sobriety who received DDLT, and it was lowest for never/ex-smoker with 6-month sobriety who received LDLT (4.3% at 3 years). For LDLT recipients, the alcohol relapse rate was not different according to abstinence period (17.7% vs. 11.6% at 3 years for short abstinent period < 3 months vs. ≥ 3 months,
P
= 0.92), but it was higher for current smokers compared with that for non/ex-smokers (22.4% vs. 5.8% at 3 years,
P
= 0.05).
Conclusion
When considering LDLT for ALD, sobriety period may not be an absolute contraindication as abstinence period showed a weak association with alcohol relapse. Smokers need careful attention for alcohol relapse.</description><subject>Alcohol use</subject><subject>Gastroenterology</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Incidence</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Liver Diseases, Alcoholic - epidemiology</subject><subject>Liver Diseases, Alcoholic - surgery</subject><subject>Liver Transplantation</subject><subject>Liver transplants</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Patients</subject><subject>Recurrence</subject><subject>Republic of Korea - epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Transplants & implants</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtrGzEUhUVpaB7tH-giCLqe5Erz0Ex3rt08wBAwLnQnNJqrROlYmkjjlPyu_MHItfNYlGyuxL3fOWdxCPnK4IQBiNPIWAVlBhwyKMoCMvGBHLBa5FlR8epj-kPDMl6Wv_fJYYy3AEwAqz-R_ZxDUzZcHJDHS6dth04j9YYq19GFjX_omdKjD5EaH-ik1_7G93SBvRoi0okZMdC5vU9zGZSLQ6_cqEbr3Vve6h0zsxFVxO906leDCjYm7geOfxEdnaHe3Do68y5JN_lJZN31bvHflM9kz6g-4pfde0R-nf1cTi-y-dX55XQyz3QuyjFjynSsaOpW1xUi5rlpO4FgQLW8rTrUTWEqpQA15ChqUXLkrWk6qFVR6LLKj8i3re8Q_N0a4yhv_Tq4FCl58hVNlUai-JbSwccY0Mgh2JUKD5KB3PQktz3J1JP815PciI531ut2hd2L5LmYBORbIKaTu8bwmv2O7RPvwaHU</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Chung, Hye Gyo</creator><creator>Sinn, Dong Hyun</creator><creator>Kang, Wonseok</creator><creator>Choi, Gyu-Seong</creator><creator>Kim, Jong Man</creator><creator>Joh, Jae-Won</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-7126-5554</orcidid></search><sort><creationdate>20210301</creationdate><title>Incidence of and Risk Factors for Alcohol Relapse After Liver Transplantation for Alcoholic Liver Disease: Comparison Between Deceased Donor and Living Donor Liver Transplantation</title><author>Chung, Hye Gyo ; Sinn, Dong Hyun ; Kang, Wonseok ; Choi, Gyu-Seong ; Kim, Jong Man ; Joh, Jae-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-1afd1498bc86eee33fbd7e0f0ab2b6dec94f6aa0ec03e78752e2bf9d08a44c563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alcohol use</topic><topic>Gastroenterology</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Incidence</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Liver Diseases, Alcoholic - epidemiology</topic><topic>Liver Diseases, Alcoholic - surgery</topic><topic>Liver Transplantation</topic><topic>Liver transplants</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Patients</topic><topic>Recurrence</topic><topic>Republic of Korea - epidemiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Hye Gyo</creatorcontrib><creatorcontrib>Sinn, Dong Hyun</creatorcontrib><creatorcontrib>Kang, Wonseok</creatorcontrib><creatorcontrib>Choi, Gyu-Seong</creatorcontrib><creatorcontrib>Kim, Jong Man</creatorcontrib><creatorcontrib>Joh, Jae-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Hye Gyo</au><au>Sinn, Dong Hyun</au><au>Kang, Wonseok</au><au>Choi, Gyu-Seong</au><au>Kim, Jong Man</au><au>Joh, Jae-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of and Risk Factors for Alcohol Relapse After Liver Transplantation for Alcoholic Liver Disease: Comparison Between Deceased Donor and Living Donor Liver Transplantation</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>25</volume><issue>3</issue><spage>672</spage><epage>680</epage><pages>672-680</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Background
There are controversies over whether patients with alcohol-related liver disease (ALD) should follow the “6-month abstinence rule” before undergoing liver transplantation (LT), especially in case of living donor LT (LDLT). We analyzed the risk of alcohol relapse among ALD patients who received LT according to donor types and abstinence period before LT.
Methods
A total of 129 patients (mean 50.7 ± 9.2 years, male 78.3%) who underwent LT between January 2000 and July 2017 for ALD at Samsung Medical Center, Seoul, Korea, were analyzed. Alcohol relapse was defined as any use of alcohol after LT.
Results
The alcohol relapse rate was lower in LDLT recipients compared with that in DDLT recipients (13.9% vs. 31.7% at 3 years,
P
= 0.013). DDLT recipient, short abstinence period (< 6 months), and current smoking status were factors associated with alcohol relapse. The alcohol relapse rate was highest (54.5% at 3 years) for current smokers without 6-month sobriety who received DDLT, and it was lowest for never/ex-smoker with 6-month sobriety who received LDLT (4.3% at 3 years). For LDLT recipients, the alcohol relapse rate was not different according to abstinence period (17.7% vs. 11.6% at 3 years for short abstinent period < 3 months vs. ≥ 3 months,
P
= 0.92), but it was higher for current smokers compared with that for non/ex-smokers (22.4% vs. 5.8% at 3 years,
P
= 0.05).
Conclusion
When considering LDLT for ALD, sobriety period may not be an absolute contraindication as abstinence period showed a weak association with alcohol relapse. Smokers need careful attention for alcohol relapse.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32095927</pmid><doi>10.1007/s11605-020-04540-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7126-5554</orcidid></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Alcohol use Gastroenterology Hepatitis Humans Incidence Liver cancer Liver cirrhosis Liver diseases Liver Diseases, Alcoholic - epidemiology Liver Diseases, Alcoholic - surgery Liver Transplantation Liver transplants Living Donors Male Medicine Medicine & Public Health Original Article Patients Recurrence Republic of Korea - epidemiology Retrospective Studies Risk Factors Surgery Transplants & implants |
| title | Incidence of and Risk Factors for Alcohol Relapse After Liver Transplantation for Alcoholic Liver Disease: Comparison Between Deceased Donor and Living Donor Liver Transplantation |
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