Ethanol Gestational Exposure Impairs Vascular Development and Endothelial Potential to Control BBB-Associated Astrocyte Function in the Developing Cerebral Cortex

Ethanol consumption during pregnancy or lactation period can induce permanent damage to the development of the central nervous system (CNS), resulting in fetal alcohol spectrum disorders (FASD). CNS development depends on proper neural cells and blood vessel (BV) development and blood-brain barrier...

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Veröffentlicht in:	Molecular neurobiology 2021-04, Vol.58 (4), p.1755-1768
Hauptverfasser:	Siqueira, Michele, Araujo, Ana Paula Bérgamo, Gomes, Flávia Carvalho Alcantara, Stipursky, Joice
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Animals, Newborn Astrocytes Astrocytes - pathology Biomedical and Life Sciences Biomedicine Blood Vessels - embryology Blood-brain barrier Blood-Brain Barrier - pathology Cell Biology Central nervous system Cerebral cortex Cerebral Cortex - embryology Connexin 43 Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Ethanol Ethanol - adverse effects Female Fetal Alcohol Spectrum Disorders - pathology Fetal alcohol syndrome Gene Expression Profiling Gene Expression Regulation Glial fibrillary acidic protein Humans IL-1β Inflammation Interleukin 1 Interleukin 6 Lactation Lipocalin Mice Neovascularization, Physiologic Neurobiology Neurology Neurosciences NF-κB protein Nitric oxide Phenotype Phenotypes Pregnancy Prenatal Exposure Delayed Effects - pathology Tumor necrosis factor Zonula occludens-1 protein
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